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Natural and pathogenic protein sequence variation affecting prion-like domains within and across human proteomes
BACKGROUND: Impaired proteostatic regulation of proteins with prion-like domains (PrLDs) is associated with a variety of human diseases including neurodegenerative disorders, myopathies, and certain forms of cancer. For many of these disorders, current models suggest a prion-like molecular mechanism...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947906/ https://www.ncbi.nlm.nih.gov/pubmed/31914925 http://dx.doi.org/10.1186/s12864-019-6425-3 |