Cargando…

Overexpression of BMP-7 reverses TGF-β1-induced epithelial-mesenchymal transition by attenuating the Wnt3/β-catenin and TGF-β1/Smad2/3 signaling pathways in HK-2 cells

Tubular epithelial cells undergoing epithelial-mesenchymal transition (EMT) is a crucial event in the progression of renal interstitial fibrosis (RIF). Bone morphogenetic protein-7 (BMP-7) has been reported to exhibit anti-fibrotic functions in various renal diseases. However, the function of BMP-7...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Yan, Lv, Shasha, Wang, Fang, Liu, Xiaoli, Cheng, Jing, Liu, Shanshan, Wang, Xiaoying, Chen, Wei, Guan, Guangju, Liu, Gang, Peng, Changliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947920/ https://www.ncbi.nlm.nih.gov/pubmed/31974602 http://dx.doi.org/10.3892/mmr.2019.10875

Ejemplares similares

EFEMP1 binds to STEAP1 to promote osteosarcoma proliferation and invasion via the Wnt/β-catenin and TGF-β/Smad2/3 signal pathways
por: Zhang, Dong, et al.
Publicado: (2022)

Activation of Wnt/β‐catenin signalling is required for TGF‐β/Smad2/3 signalling during myofibroblast proliferation
por: Xu, Liang, et al.
Publicado: (2017)

Lysyl hydroxylase 3 increases collagen deposition and promotes pulmonary fibrosis by activating TGFβ1/Smad3 and Wnt/β-catenin pathways
por: Shao, Songjun, et al.
Publicado: (2019)

BMP-4, TGF-β and Smad3 as Modulators of Synovial Fluid Cells Viability
por: Sousa, Eduardo Branco de, et al.
Publicado: (2021)

Agrin Binds BMP2, BMP4 and TGFβ1
por: Bányai, László, et al.
Publicado: (2010)

Msk is required for nuclear import of TGF-β/BMP-activated Smads
por: Xu, Lan, et al.
Publicado: (2007)

The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies
por: Zou, Ming-Li, et al.
Publicado: (2021)

Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling
por: Li, Wenqing, et al.
Publicado: (2017)

Pirfenidone alleviates pulmonary fibrosis in vitro and in vivo through regulating Wnt/GSK-3β/β-catenin and TGF-β1/Smad2/3 signaling pathways
por: Lv, Qun, et al.
Publicado: (2020)

BMP1 controls TGFβ1 activation via cleavage of latent TGFβ-binding protein
por: Ge, Gaoxiang, et al.
Publicado: (2006)

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
por: Bertrand-Chapel, Adrien, et al.
Publicado: (2022)

Catalpol Protects Against Pulmonary Fibrosis Through Inhibiting TGF-β1/Smad3 and Wnt/β-Catenin Signaling Pathways
por: Yang, Fan, et al.
Publicado: (2021)

Long Non-Coding RNA (LncRNA)-ATB Promotes Inflammation, Cell Apoptosis and Senescence in Transforming Growth Factor-β1 (TGF-β1) Induced Human Kidney 2 (HK-2) Cells via TGFβ/SMAD2/3 Signaling Pathway
por: Sun, Han, et al.
Publicado: (2020)

Endoplasmic reticulum stress inhibits 3D Matrigel‐induced vasculogenic mimicry of breast cancer cells via TGF‐β1/Smad2/3 and β‐catenin signaling
por: Liu, Huifen, et al.
Publicado: (2021)

Extracranial arteriovenous malformations demonstrate dysregulated TGF-β/BMP signaling and increased circulating TGF-β1
por: Wei, Ting, et al.
Publicado: (2022)

TGF-β Prevents Phosphate-Induced Osteogenesis through Inhibition of BMP and Wnt/β-Catenin Pathways
por: Guerrero, Fátima, et al.
Publicado: (2014)

AMPK inhibits Smad3‐mediated autoinduction of TGF‐β1 in gastric cancer cells
por: Zou, Junrong, et al.
Publicado: (2021)

STAT3 selectively interacts with Smad3 to antagonize TGF-β signaling
por: Wang, Gaohang, et al.
Publicado: (2015)

Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-β effectors
por: BabuRajendran, Nithya, et al.
Publicado: (2010)

Interfering with TGFβ-induced Smad3 nuclear accumulation differentially affects TGFβ-dependent gene expression
por: Lindemann, Ralph K, et al.
Publicado: (2003)

Polymorphisms of TGF-β1 and TGF-β3 in Chinese women with gestational diabetes mellitus
por: Xu, Yinglei, et al.
Publicado: (2020)

TGF‐β/Smad and Wnt/β‐catenin signaling pathways are involved in renal fibrosis and its therapies
por: Ying, Jialiang, et al.
Publicado: (2020)

SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis
por: Peng, Changliang, et al.
Publicado: (2017)

Wnt3a Induces Myofibroblast Differentiation by Upregulating TGF-β Signaling Through SMAD2 in a β-Catenin-Dependent Manner
por: Carthy, Jon M., et al.
Publicado: (2011)

Protection from β-cell apoptosis by inhibition of TGF-β/Smad3 signaling
por: Lee, Ji-Hyeon, et al.
Publicado: (2020)

TGF-β and TGF-β/Smad Signaling in the Interactions between Echinococcus multilocularis and Its Hosts
por: Wang, Junhua, et al.
Publicado: (2013)

Editorial: TGF-β and BMP signaling in cancer
por: Yan, Xiaohua, et al.
Publicado: (2022)

Spatio-Temporal Distribution of Smads and Role of Smads/TGF-β/BMP-4 in the Regulation of Mouse Bladder Organogenesis
por: Islam, Syed S., et al.
Publicado: (2013)

Correction: TGF-β Prevents Phosphate-Induced Osteogenesis through Inhibition of BMP and Wnt/β-Catenin Pathways
Publicado: (2014)

Rejuvenation by inhibiting TGF-β1/pSmad signaling
por: Corder, Elizabeth H., et al.
Publicado: (2015)

Aspirin inhibits endometrial fibrosis by suppressing the TGF-β1-Smad2/Smad3 pathway in intrauterine adhesions
por: Zhang, Zihui, et al.
Publicado: (2020)

Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling
por: Aragón, Eric, et al.
Publicado: (2019)

TGF-β/Smad signaling in renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2015)

The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage
por: Wang, Weiguang, et al.
Publicado: (2019)

Aptamers and Their Potential to Selectively Target Aspects of EGF, Wnt/β-Catenin and TGFβ–Smad Family Signaling
por: Conidi, Andrea, et al.
Publicado: (2013)

Hierarchy of TGFβ/SMAD, Hippo/YAP/TAZ, and Wnt/β-catenin signaling in melanoma phenotype switching
por: Lüönd, Fabiana, et al.
Publicado: (2021)

Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways
por: Liu, Ning, et al.
Publicado: (2019)

ERK1/2 drives IL-1β-induced expression of TGF-β1 and BMP-2 in torn tendons
por: Morita, Wataru, et al.
Publicado: (2019)

Linggui Qihua Decoction Inhibits Atrial Fibrosis by Regulating TGF-β1/Smad2/3 Signal Pathway
por: Xiong, Shuang, et al.
Publicado: (2023)

A Water-Soluble Hydrogen Sulfide Donor Suppresses the Growth of Hepatocellular Carcinoma via Inhibiting the AKT/GSK-3β/β-Catenin and TGF-β/Smad2/3 Signaling Pathways
por: Duan, Shao-Feng, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_p3e9vk7imqi6f0tsdjv2e0rrbi