Silencing of AURKA augments the antitumor efficacy of the AURKA inhibitor MLN8237 on neuroblastoma cells

BACKGROUND: Aurora kinase A (AURKA) has been implicated in the regulation of cell cycle progression, mitosis and a key number of oncogenic signaling pathways in various malignancies including neuroblastoma. Small molecule inhibitors of AURKA have shown potential, but still not as good as expected ef...

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Detalles Bibliográficos
Autores principales: Yang, Yan, Ding, Lili, Zhou, Qi, Fen, Li, Cao, Yuhua, Sun, Junjie, Zhou, Xuefeng, Liu, Aiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947931/
https://www.ncbi.nlm.nih.gov/pubmed/31920463
http://dx.doi.org/10.1186/s12935-019-1072-y

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