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Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems
In the study of multivalent interactions at interfaces, as occur for example at cell membranes, the density of the ligands or receptors displayed at the interface plays a pivotal role, affecting both the overall binding affinities and the valencies involved in the interactions. In order to control t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948118/ https://www.ncbi.nlm.nih.gov/pubmed/31921546 http://dx.doi.org/10.1002/open.201900290 |
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author | Di Iorio, Daniele Huskens, Jurriaan |
author_facet | Di Iorio, Daniele Huskens, Jurriaan |
author_sort | Di Iorio, Daniele |
collection | PubMed |
description | In the study of multivalent interactions at interfaces, as occur for example at cell membranes, the density of the ligands or receptors displayed at the interface plays a pivotal role, affecting both the overall binding affinities and the valencies involved in the interactions. In order to control the ligand density at the interface, several approaches have been developed, and they concern the functionalization of a wide range of materials. Here, different methods employed in the modification of surfaces with controlled densities of ligands are being reviewed. Examples of such methods encompass the formation of self‐assembled monolayers (SAMs), supported lipid bilayers (SLBs) and polymeric layers on surfaces. Particular emphasis is given to the methods employed in the study of different types of multivalent biological interactions occurring at the functionalized surfaces and their working principles. |
format | Online Article Text |
id | pubmed-6948118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69481182020-01-09 Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems Di Iorio, Daniele Huskens, Jurriaan ChemistryOpen Reviews In the study of multivalent interactions at interfaces, as occur for example at cell membranes, the density of the ligands or receptors displayed at the interface plays a pivotal role, affecting both the overall binding affinities and the valencies involved in the interactions. In order to control the ligand density at the interface, several approaches have been developed, and they concern the functionalization of a wide range of materials. Here, different methods employed in the modification of surfaces with controlled densities of ligands are being reviewed. Examples of such methods encompass the formation of self‐assembled monolayers (SAMs), supported lipid bilayers (SLBs) and polymeric layers on surfaces. Particular emphasis is given to the methods employed in the study of different types of multivalent biological interactions occurring at the functionalized surfaces and their working principles. John Wiley and Sons Inc. 2020-01-08 /pmc/articles/PMC6948118/ /pubmed/31921546 http://dx.doi.org/10.1002/open.201900290 Text en ©2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Reviews Di Iorio, Daniele Huskens, Jurriaan Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems |
title | Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems |
title_full | Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems |
title_fullStr | Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems |
title_full_unstemmed | Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems |
title_short | Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems |
title_sort | surface modification with control over ligand density for the study of multivalent biological systems |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948118/ https://www.ncbi.nlm.nih.gov/pubmed/31921546 http://dx.doi.org/10.1002/open.201900290 |
work_keys_str_mv | AT diioriodaniele surfacemodificationwithcontroloverliganddensityforthestudyofmultivalentbiologicalsystems AT huskensjurriaan surfacemodificationwithcontroloverliganddensityforthestudyofmultivalentbiologicalsystems |