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Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems

In the study of multivalent interactions at interfaces, as occur for example at cell membranes, the density of the ligands or receptors displayed at the interface plays a pivotal role, affecting both the overall binding affinities and the valencies involved in the interactions. In order to control t...

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Detalles Bibliográficos
Autores principales: Di Iorio, Daniele, Huskens, Jurriaan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948118/
https://www.ncbi.nlm.nih.gov/pubmed/31921546
http://dx.doi.org/10.1002/open.201900290
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author Di Iorio, Daniele
Huskens, Jurriaan
author_facet Di Iorio, Daniele
Huskens, Jurriaan
author_sort Di Iorio, Daniele
collection PubMed
description In the study of multivalent interactions at interfaces, as occur for example at cell membranes, the density of the ligands or receptors displayed at the interface plays a pivotal role, affecting both the overall binding affinities and the valencies involved in the interactions. In order to control the ligand density at the interface, several approaches have been developed, and they concern the functionalization of a wide range of materials. Here, different methods employed in the modification of surfaces with controlled densities of ligands are being reviewed. Examples of such methods encompass the formation of self‐assembled monolayers (SAMs), supported lipid bilayers (SLBs) and polymeric layers on surfaces. Particular emphasis is given to the methods employed in the study of different types of multivalent biological interactions occurring at the functionalized surfaces and their working principles.
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spelling pubmed-69481182020-01-09 Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems Di Iorio, Daniele Huskens, Jurriaan ChemistryOpen Reviews In the study of multivalent interactions at interfaces, as occur for example at cell membranes, the density of the ligands or receptors displayed at the interface plays a pivotal role, affecting both the overall binding affinities and the valencies involved in the interactions. In order to control the ligand density at the interface, several approaches have been developed, and they concern the functionalization of a wide range of materials. Here, different methods employed in the modification of surfaces with controlled densities of ligands are being reviewed. Examples of such methods encompass the formation of self‐assembled monolayers (SAMs), supported lipid bilayers (SLBs) and polymeric layers on surfaces. Particular emphasis is given to the methods employed in the study of different types of multivalent biological interactions occurring at the functionalized surfaces and their working principles. John Wiley and Sons Inc. 2020-01-08 /pmc/articles/PMC6948118/ /pubmed/31921546 http://dx.doi.org/10.1002/open.201900290 Text en ©2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Reviews
Di Iorio, Daniele
Huskens, Jurriaan
Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems
title Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems
title_full Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems
title_fullStr Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems
title_full_unstemmed Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems
title_short Surface Modification with Control over Ligand Density for the Study of Multivalent Biological Systems
title_sort surface modification with control over ligand density for the study of multivalent biological systems
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948118/
https://www.ncbi.nlm.nih.gov/pubmed/31921546
http://dx.doi.org/10.1002/open.201900290
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