MEF2C repressor variant deregulation leads to cell cycle re-entry and development of heart failure

BACKGROUND: A pathophysiological link exists between dysregulation of MEF2C transcription factors and heart failure (HF), but the underlying mechanisms remain elusive. Alternative splicing of MEF2C exons α, β and γ provides transcript diversity with gene activation or repression functionalities. MET...

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Detalles Bibliográficos
Autores principales: Pereira, Ana Helena M., Cardoso, Alisson C., Consonni, Silvio R., Oliveira, Renata R., Saito, Angela, Vaggione, Maria Luisa B., Matos-Souza, Jose R., Carazzolle, Marcelo F., Gonçalves, Anderson, Fernandes, Juliano L., Ribeiro, Gustavo C.A., Lopes, Mauricio M., Molkentin, Jeffery D., Franchini, Kleber G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948164/
https://www.ncbi.nlm.nih.gov/pubmed/31911274
http://dx.doi.org/10.1016/j.ebiom.2019.11.032

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