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Qualitative analysis of a stochastic SEITR epidemic model with multiple stages of infection and treatment

We present a mathematical analysis of the transmission of certain diseases using a stochastic susceptible-exposed-infectious-treated-recovered (SEITR) model with multiple stages of infection and treatment and explore the effects of treatments and external fluctuations in the transmission, treatment...

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Autores principales: Otunuga, Olusegun Michael, Ogunsolu, Mobolaji O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948245/
https://www.ncbi.nlm.nih.gov/pubmed/31930182
http://dx.doi.org/10.1016/j.idm.2019.12.003
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author Otunuga, Olusegun Michael
Ogunsolu, Mobolaji O.
author_facet Otunuga, Olusegun Michael
Ogunsolu, Mobolaji O.
author_sort Otunuga, Olusegun Michael
collection PubMed
description We present a mathematical analysis of the transmission of certain diseases using a stochastic susceptible-exposed-infectious-treated-recovered (SEITR) model with multiple stages of infection and treatment and explore the effects of treatments and external fluctuations in the transmission, treatment and recovery rates. We assume external fluctuations are caused by variability in the number of contacts between infected and susceptible individuals. It is shown that the expected number of secondary infections produced (in the absence of noise) reduces as treatment is introduced into the population. By defining [Formula: see text] and [Formula: see text] as the basic deterministic and stochastic reproduction numbers, respectively, in stage n of infection and treatment, we show mathematically that as the intensity of the noise in the transmission, treatment and recovery rates increases, the number of secondary cases of infection increases. The global stability of the disease-free and endemic equilibrium for the deterministic and stochastic SEITR models is also presented. The work presented is demonstrated using parameter values relevant to the transmission dynamics of Influenza in the United States from October 1, 2018 through May 4, 2019 influenza seasons.
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spelling pubmed-69482452020-01-10 Qualitative analysis of a stochastic SEITR epidemic model with multiple stages of infection and treatment Otunuga, Olusegun Michael Ogunsolu, Mobolaji O. Infect Dis Model Original Research Article We present a mathematical analysis of the transmission of certain diseases using a stochastic susceptible-exposed-infectious-treated-recovered (SEITR) model with multiple stages of infection and treatment and explore the effects of treatments and external fluctuations in the transmission, treatment and recovery rates. We assume external fluctuations are caused by variability in the number of contacts between infected and susceptible individuals. It is shown that the expected number of secondary infections produced (in the absence of noise) reduces as treatment is introduced into the population. By defining [Formula: see text] and [Formula: see text] as the basic deterministic and stochastic reproduction numbers, respectively, in stage n of infection and treatment, we show mathematically that as the intensity of the noise in the transmission, treatment and recovery rates increases, the number of secondary cases of infection increases. The global stability of the disease-free and endemic equilibrium for the deterministic and stochastic SEITR models is also presented. The work presented is demonstrated using parameter values relevant to the transmission dynamics of Influenza in the United States from October 1, 2018 through May 4, 2019 influenza seasons. KeAi Publishing 2019-12-14 /pmc/articles/PMC6948245/ /pubmed/31930182 http://dx.doi.org/10.1016/j.idm.2019.12.003 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Otunuga, Olusegun Michael
Ogunsolu, Mobolaji O.
Qualitative analysis of a stochastic SEITR epidemic model with multiple stages of infection and treatment
title Qualitative analysis of a stochastic SEITR epidemic model with multiple stages of infection and treatment
title_full Qualitative analysis of a stochastic SEITR epidemic model with multiple stages of infection and treatment
title_fullStr Qualitative analysis of a stochastic SEITR epidemic model with multiple stages of infection and treatment
title_full_unstemmed Qualitative analysis of a stochastic SEITR epidemic model with multiple stages of infection and treatment
title_short Qualitative analysis of a stochastic SEITR epidemic model with multiple stages of infection and treatment
title_sort qualitative analysis of a stochastic seitr epidemic model with multiple stages of infection and treatment
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948245/
https://www.ncbi.nlm.nih.gov/pubmed/31930182
http://dx.doi.org/10.1016/j.idm.2019.12.003
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