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Qualitative analysis of a stochastic SEITR epidemic model with multiple stages of infection and treatment
We present a mathematical analysis of the transmission of certain diseases using a stochastic susceptible-exposed-infectious-treated-recovered (SEITR) model with multiple stages of infection and treatment and explore the effects of treatments and external fluctuations in the transmission, treatment...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
KeAi Publishing
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948245/ https://www.ncbi.nlm.nih.gov/pubmed/31930182 http://dx.doi.org/10.1016/j.idm.2019.12.003 |
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author | Otunuga, Olusegun Michael Ogunsolu, Mobolaji O. |
author_facet | Otunuga, Olusegun Michael Ogunsolu, Mobolaji O. |
author_sort | Otunuga, Olusegun Michael |
collection | PubMed |
description | We present a mathematical analysis of the transmission of certain diseases using a stochastic susceptible-exposed-infectious-treated-recovered (SEITR) model with multiple stages of infection and treatment and explore the effects of treatments and external fluctuations in the transmission, treatment and recovery rates. We assume external fluctuations are caused by variability in the number of contacts between infected and susceptible individuals. It is shown that the expected number of secondary infections produced (in the absence of noise) reduces as treatment is introduced into the population. By defining [Formula: see text] and [Formula: see text] as the basic deterministic and stochastic reproduction numbers, respectively, in stage n of infection and treatment, we show mathematically that as the intensity of the noise in the transmission, treatment and recovery rates increases, the number of secondary cases of infection increases. The global stability of the disease-free and endemic equilibrium for the deterministic and stochastic SEITR models is also presented. The work presented is demonstrated using parameter values relevant to the transmission dynamics of Influenza in the United States from October 1, 2018 through May 4, 2019 influenza seasons. |
format | Online Article Text |
id | pubmed-6948245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | KeAi Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-69482452020-01-10 Qualitative analysis of a stochastic SEITR epidemic model with multiple stages of infection and treatment Otunuga, Olusegun Michael Ogunsolu, Mobolaji O. Infect Dis Model Original Research Article We present a mathematical analysis of the transmission of certain diseases using a stochastic susceptible-exposed-infectious-treated-recovered (SEITR) model with multiple stages of infection and treatment and explore the effects of treatments and external fluctuations in the transmission, treatment and recovery rates. We assume external fluctuations are caused by variability in the number of contacts between infected and susceptible individuals. It is shown that the expected number of secondary infections produced (in the absence of noise) reduces as treatment is introduced into the population. By defining [Formula: see text] and [Formula: see text] as the basic deterministic and stochastic reproduction numbers, respectively, in stage n of infection and treatment, we show mathematically that as the intensity of the noise in the transmission, treatment and recovery rates increases, the number of secondary cases of infection increases. The global stability of the disease-free and endemic equilibrium for the deterministic and stochastic SEITR models is also presented. The work presented is demonstrated using parameter values relevant to the transmission dynamics of Influenza in the United States from October 1, 2018 through May 4, 2019 influenza seasons. KeAi Publishing 2019-12-14 /pmc/articles/PMC6948245/ /pubmed/31930182 http://dx.doi.org/10.1016/j.idm.2019.12.003 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Research Article Otunuga, Olusegun Michael Ogunsolu, Mobolaji O. Qualitative analysis of a stochastic SEITR epidemic model with multiple stages of infection and treatment |
title | Qualitative analysis of a stochastic SEITR epidemic model with multiple stages of infection and treatment |
title_full | Qualitative analysis of a stochastic SEITR epidemic model with multiple stages of infection and treatment |
title_fullStr | Qualitative analysis of a stochastic SEITR epidemic model with multiple stages of infection and treatment |
title_full_unstemmed | Qualitative analysis of a stochastic SEITR epidemic model with multiple stages of infection and treatment |
title_short | Qualitative analysis of a stochastic SEITR epidemic model with multiple stages of infection and treatment |
title_sort | qualitative analysis of a stochastic seitr epidemic model with multiple stages of infection and treatment |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948245/ https://www.ncbi.nlm.nih.gov/pubmed/31930182 http://dx.doi.org/10.1016/j.idm.2019.12.003 |
work_keys_str_mv | AT otunugaolusegunmichael qualitativeanalysisofastochasticseitrepidemicmodelwithmultiplestagesofinfectionandtreatment AT ogunsolumobolajio qualitativeanalysisofastochasticseitrepidemicmodelwithmultiplestagesofinfectionandtreatment |