Prelamin A mediates myocardial inflammation in dilated and HIV-associated cardiomyopathies

Cardiomyopathies are complex heart muscle diseases that can be inherited or acquired. Dilated cardiomyopathy can result from mutations in LMNA, encoding the nuclear intermediate filament proteins lamin A/C. Some LMNA mutations lead to accumulation of the lamin A precursor, prelamin A, which is disea...

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Detalles Bibliográficos
Autores principales: Brayson, Daniel, Frustaci, Andrea, Verardo, Romina, Chimenti, Cristina, Russo, Matteo Antonio, Hayward, Robert, Ahmad, Sadia, Vizcay-Barrena, Gema, Protti, Andrea, Zammit, Peter S., dos Remedios, Cristobal G., Ehler, Elisabeth, Shah, Ajay M., Shanahan, Catherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6948859/
https://www.ncbi.nlm.nih.gov/pubmed/31622279
http://dx.doi.org/10.1172/jci.insight.126315

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