Neuron-based high-content assay and screen for CNS active mitotherapeutics

Impaired mitochondrial dynamics and function are hallmarks of many neurological and psychiatric disorders, but direct screens for mitotherapeutics using neurons have not been reported. We developed a multiplexed and high-content screening assay using primary neurons and identified 67 small-molecule...

Descripción completa

Detalles Bibliográficos
Autores principales: Varkuti, Boglarka H., Kepiro, Miklos, Liu, Ze, Vick, Kyle, Avchalumov, Yosef, Pacifico, Rodrigo, MacMullen, Courtney M., Kamenecka, Theodore M., Puthanveettil, Sathyanarayanan V., Davis, Ronald L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949038/
https://www.ncbi.nlm.nih.gov/pubmed/31934620
http://dx.doi.org/10.1126/sciadv.aaw8702

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949038/
https://www.ncbi.nlm.nih.gov/pubmed/31934620
http://dx.doi.org/10.1126/sciadv.aaw8702

Ejemplares similares