CTNNB1/β-catenin dysfunction contributes to adiposity by regulating the cross-talk of mature adipocytes and preadipocytes

Overnutrition results in adiposity and chronic inflammation with expansion of white adipose tissue (WAT). However, genetic factors controlling fat mass and adiposity remain largely undetermined. We applied whole-exome sequencing in young obese subjects and identified rare gain-of-function mutations...

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Detalles Bibliográficos
Autores principales: Chen, Maopei, Lu, Peng, Ma, Qinyun, Cao, Yanan, Chen, Na, Li, Wen, Zhao, Shaoqian, Chen, Banru, Shi, Juan, Sun, Yingkai, Shen, Hongbin, Sun, Liangdan, Shen, Juan, Liao, Qijun, Zhang, Yifei, Hong, Jie, Gu, Weiqiong, Liu, Ruixin, Ning, Guang, Wang, Weiqing, Wang, Jiqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949042/
https://www.ncbi.nlm.nih.gov/pubmed/31934629
http://dx.doi.org/10.1126/sciadv.aax9605

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