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Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies
Epidemiological studies have indicated that blood vitamin D levels are linked to cancer. Here we conducted a dose–response meta-analysis based on published observational studies to evaluate the association of vitamin D intake and blood vitamin D levels with breast cancer susceptibility. PubMed, EMBA...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949087/ https://www.ncbi.nlm.nih.gov/pubmed/31884419 http://dx.doi.org/10.18632/aging.102597 |
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author | Song, Dingli Deng, Yujiao Liu, Kang Zhou, Linghui Li, Na Zheng, Yi Hao, Qian Yang, Si Wu, Ying Zhai, Zhen Li, Hongtao Dai, Zhijun |
author_facet | Song, Dingli Deng, Yujiao Liu, Kang Zhou, Linghui Li, Na Zheng, Yi Hao, Qian Yang, Si Wu, Ying Zhai, Zhen Li, Hongtao Dai, Zhijun |
author_sort | Song, Dingli |
collection | PubMed |
description | Epidemiological studies have indicated that blood vitamin D levels are linked to cancer. Here we conducted a dose–response meta-analysis based on published observational studies to evaluate the association of vitamin D intake and blood vitamin D levels with breast cancer susceptibility. PubMed, EMBASE, and Web of Science databases were searched up to January 2019. The pooled odds ratio (OR) and 95% confidence intervals (CIs) were extracted to estimate the risk. We identified 70 relevant studies on blood vitamin D levels (50 studies) and vitamin D intake (20 studies), respectively. Linear and nonlinear trend analyses were performed and showed that an increase in blood vitamin D levels by 5 nmol/l was associated with a 6% decrease in breast cancer risk (OR = 0.94, 95% CI = 0.93–0.96). Similar results were obtained for premenopausal (OR = 0.96, 95% CI = 0.93–0.99) and postmenopausal women (OR = 0.96, 95% CI = 0.94–0.98). The pooled OR of breast cancer risk for a 400IU/day increase in vitamin D intake was 0.97 (95% CI = 0.92–1.02). In conclusion, we found that breast cancer risk was inversely related to blood vitamin D levels; however, no significant association was observed in vitamin D intake. |
format | Online Article Text |
id | pubmed-6949087 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-69490872020-01-13 Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies Song, Dingli Deng, Yujiao Liu, Kang Zhou, Linghui Li, Na Zheng, Yi Hao, Qian Yang, Si Wu, Ying Zhai, Zhen Li, Hongtao Dai, Zhijun Aging (Albany NY) Research Paper Epidemiological studies have indicated that blood vitamin D levels are linked to cancer. Here we conducted a dose–response meta-analysis based on published observational studies to evaluate the association of vitamin D intake and blood vitamin D levels with breast cancer susceptibility. PubMed, EMBASE, and Web of Science databases were searched up to January 2019. The pooled odds ratio (OR) and 95% confidence intervals (CIs) were extracted to estimate the risk. We identified 70 relevant studies on blood vitamin D levels (50 studies) and vitamin D intake (20 studies), respectively. Linear and nonlinear trend analyses were performed and showed that an increase in blood vitamin D levels by 5 nmol/l was associated with a 6% decrease in breast cancer risk (OR = 0.94, 95% CI = 0.93–0.96). Similar results were obtained for premenopausal (OR = 0.96, 95% CI = 0.93–0.99) and postmenopausal women (OR = 0.96, 95% CI = 0.94–0.98). The pooled OR of breast cancer risk for a 400IU/day increase in vitamin D intake was 0.97 (95% CI = 0.92–1.02). In conclusion, we found that breast cancer risk was inversely related to blood vitamin D levels; however, no significant association was observed in vitamin D intake. Impact Journals 2019-12-28 /pmc/articles/PMC6949087/ /pubmed/31884419 http://dx.doi.org/10.18632/aging.102597 Text en Copyright © 2019 Song et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Song, Dingli Deng, Yujiao Liu, Kang Zhou, Linghui Li, Na Zheng, Yi Hao, Qian Yang, Si Wu, Ying Zhai, Zhen Li, Hongtao Dai, Zhijun Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies |
title | Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies |
title_full | Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies |
title_fullStr | Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies |
title_full_unstemmed | Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies |
title_short | Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies |
title_sort | vitamin d intake, blood vitamin d levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949087/ https://www.ncbi.nlm.nih.gov/pubmed/31884419 http://dx.doi.org/10.18632/aging.102597 |
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