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Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies

Epidemiological studies have indicated that blood vitamin D levels are linked to cancer. Here we conducted a dose–response meta-analysis based on published observational studies to evaluate the association of vitamin D intake and blood vitamin D levels with breast cancer susceptibility. PubMed, EMBA...

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Autores principales: Song, Dingli, Deng, Yujiao, Liu, Kang, Zhou, Linghui, Li, Na, Zheng, Yi, Hao, Qian, Yang, Si, Wu, Ying, Zhai, Zhen, Li, Hongtao, Dai, Zhijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949087/
https://www.ncbi.nlm.nih.gov/pubmed/31884419
http://dx.doi.org/10.18632/aging.102597
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author Song, Dingli
Deng, Yujiao
Liu, Kang
Zhou, Linghui
Li, Na
Zheng, Yi
Hao, Qian
Yang, Si
Wu, Ying
Zhai, Zhen
Li, Hongtao
Dai, Zhijun
author_facet Song, Dingli
Deng, Yujiao
Liu, Kang
Zhou, Linghui
Li, Na
Zheng, Yi
Hao, Qian
Yang, Si
Wu, Ying
Zhai, Zhen
Li, Hongtao
Dai, Zhijun
author_sort Song, Dingli
collection PubMed
description Epidemiological studies have indicated that blood vitamin D levels are linked to cancer. Here we conducted a dose–response meta-analysis based on published observational studies to evaluate the association of vitamin D intake and blood vitamin D levels with breast cancer susceptibility. PubMed, EMBASE, and Web of Science databases were searched up to January 2019. The pooled odds ratio (OR) and 95% confidence intervals (CIs) were extracted to estimate the risk. We identified 70 relevant studies on blood vitamin D levels (50 studies) and vitamin D intake (20 studies), respectively. Linear and nonlinear trend analyses were performed and showed that an increase in blood vitamin D levels by 5 nmol/l was associated with a 6% decrease in breast cancer risk (OR = 0.94, 95% CI = 0.93–0.96). Similar results were obtained for premenopausal (OR = 0.96, 95% CI = 0.93–0.99) and postmenopausal women (OR = 0.96, 95% CI = 0.94–0.98). The pooled OR of breast cancer risk for a 400IU/day increase in vitamin D intake was 0.97 (95% CI = 0.92–1.02). In conclusion, we found that breast cancer risk was inversely related to blood vitamin D levels; however, no significant association was observed in vitamin D intake.
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spelling pubmed-69490872020-01-13 Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies Song, Dingli Deng, Yujiao Liu, Kang Zhou, Linghui Li, Na Zheng, Yi Hao, Qian Yang, Si Wu, Ying Zhai, Zhen Li, Hongtao Dai, Zhijun Aging (Albany NY) Research Paper Epidemiological studies have indicated that blood vitamin D levels are linked to cancer. Here we conducted a dose–response meta-analysis based on published observational studies to evaluate the association of vitamin D intake and blood vitamin D levels with breast cancer susceptibility. PubMed, EMBASE, and Web of Science databases were searched up to January 2019. The pooled odds ratio (OR) and 95% confidence intervals (CIs) were extracted to estimate the risk. We identified 70 relevant studies on blood vitamin D levels (50 studies) and vitamin D intake (20 studies), respectively. Linear and nonlinear trend analyses were performed and showed that an increase in blood vitamin D levels by 5 nmol/l was associated with a 6% decrease in breast cancer risk (OR = 0.94, 95% CI = 0.93–0.96). Similar results were obtained for premenopausal (OR = 0.96, 95% CI = 0.93–0.99) and postmenopausal women (OR = 0.96, 95% CI = 0.94–0.98). The pooled OR of breast cancer risk for a 400IU/day increase in vitamin D intake was 0.97 (95% CI = 0.92–1.02). In conclusion, we found that breast cancer risk was inversely related to blood vitamin D levels; however, no significant association was observed in vitamin D intake. Impact Journals 2019-12-28 /pmc/articles/PMC6949087/ /pubmed/31884419 http://dx.doi.org/10.18632/aging.102597 Text en Copyright © 2019 Song et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Song, Dingli
Deng, Yujiao
Liu, Kang
Zhou, Linghui
Li, Na
Zheng, Yi
Hao, Qian
Yang, Si
Wu, Ying
Zhai, Zhen
Li, Hongtao
Dai, Zhijun
Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies
title Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies
title_full Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies
title_fullStr Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies
title_full_unstemmed Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies
title_short Vitamin D intake, blood vitamin D levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies
title_sort vitamin d intake, blood vitamin d levels, and the risk of breast cancer: a dose-response meta-analysis of observational studies
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949087/
https://www.ncbi.nlm.nih.gov/pubmed/31884419
http://dx.doi.org/10.18632/aging.102597
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