Cargando…

Suppression of protein degradation by leucine requires its conversion to β-hydroxy-β-methyl butyrate in C2C12 myotubes

The aims of this study were to investigate whether the inhibitory effect of Leucine (Leu) on starvation-induced protein degradation was mediated by its metabolite β-hydroxy-β-methyl butyrate (HMB), and to explore the mechanisms involved. The results showed that the beneficial effects of Leu on prote...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duan, Yehui, Zhong, Yinzhao, Song, Bo, Zheng, Changbing, Xu, Kang, Kong, Xiangfeng, Li, Fengna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949090/ https://www.ncbi.nlm.nih.gov/pubmed/31881014 http://dx.doi.org/10.18632/aging.102509

Ejemplares similares

Dietary Beta-Hydroxy Beta-Methyl Butyrate Supplementation Alleviates Liver Injury in Lipopolysaccharide-Challenged Piglets
por: Duan, Yehui, et al.
Publicado: (2021)

β-Hydroxy-β-methyl Butyrate Regulates the Lipid Metabolism, Mitochondrial Function, and Fat Browning of Adipocytes
por: Duan, Geyan, et al.
Publicado: (2023)

Conversion of leucine to β‐hydroxy‐β‐methylbutyrate by α‐keto isocaproate dioxygenase is required for a potent stimulation of protein synthesis in L6 rat myotubes
por: Girón, María D., et al.
Publicado: (2015)

Alterations of the Muscular Fatty Acid Composition and Serum Metabolome in Bama Xiang Mini-Pigs Exposed to Dietary Beta-Hydroxy Beta-Methyl Butyrate
por: Zheng, Changbing, et al.
Publicado: (2021)

Dietary Beta-Hydroxy-Beta-Methyl Butyrate Supplementation Inhibits Hepatic Fat Deposition via Regulating Gut Microbiota in Broiler Chickens
por: Zhang, Shiyu, et al.
Publicado: (2022)

Dietary supplementation with betaine or glycine improves the carcass trait, meat quality and lipid metabolism of finishing mini-pigs
por: Zhong, Yinzhao, et al.
Publicado: (2021)

Flavonoids from Mulberry Leaves Alleviate Lipid Dysmetabolism in High Fat Diet-Fed Mice: Involvement of Gut Microbiota
por: Zhong, Yinzhao, et al.
Publicado: (2020)

Dietary Supplementation With Leucine or in Combination With Arginine Decreases Body Fat Weight and Alters Gut Microbiota Composition in Finishing Pigs
por: Hu, Chengjun, et al.
Publicado: (2019)

Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis
por: Zhang, Lingyu, et al.
Publicado: (2020)

The Leucine Catabolite and Dietary Supplement β-Hydroxy-β-Methyl Butyrate (HMB) as an Epigenetic Regulator in Muscle Progenitor Cells
por: Cavallucci, Virve, et al.
Publicado: (2021)

Inflammatory Links Between High Fat Diets and Diseases
por: Duan, Yehui, et al.
Publicado: (2018)

Proteasome- and Calpain-Mediated Proteolysis, but Not Autophagy, Is Required for Leucine-Induced Protein Synthesis in C2C12 Myotubes
por: Osburn, Shelby C., et al.
Publicado: (2021)

HMB Improves Lipid Metabolism of Bama Xiang Mini-Pigs via Modulating the Bacteroidetes-Acetic Acid-AMPKα Axis
por: Zheng, Jie, et al.
Publicado: (2021)

Antioxidant mechanism of tea polyphenols and its impact on health benefits
por: Yan, Zhaoming, et al.
Publicado: (2020)

A Combination of Acetate, Propionate, and Butyrate Increases Glucose Uptake in C2C12 Myotubes
por: Otten, Britt M. J., et al.
Publicado: (2023)

Equivalent Hypertrophy and Strength Gains in β-Hydroxy-β-Methylbutyrate- or Leucine-supplemented Men
por: JAKUBOWSKI, JOSEPHINE S., et al.
Publicado: (2019)

Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes
por: Liang, Chunzi, et al.
Publicado: (2014)

Comparisons of carcass traits, meat quality, and serum metabolome between Shaziling and Yorkshire pigs
por: Song, Bo, et al.
Publicado: (2021)

SAT128 Low Concentration Of Butyrate Reverts PA-induced Atrophic Condition On C2C12 Myotubes
por: Tini, Sabrina, et al.
Publicado: (2023)

An umbrella review of systematic reviews of β‐hydroxy‐β‐methyl butyrate supplementation in ageing and clinical practice
por: Phillips, Stuart M., et al.
Publicado: (2022)

Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism
por: Wilkinson, D J, et al.
Publicado: (2013)

17β-estradiol upregulates oxytocin and the oxytocin receptor in C2C12 myotubes
por: Berio, Enrica, et al.
Publicado: (2017)

Net Absorption and Metabolism of β-Hydroxy- β-Methyl Butyrate during Late Gestation in a Pig Model
por: Hu, Liang, et al.
Publicado: (2020)

Effects of the Combination of β-Hydroxy-β-Methyl Butyrate and R(+) Lipoic Acid in a Cellular Model of Sarcopenia
por: Mannelli, Lorenzo Di Cesare, et al.
Publicado: (2020)

A (14)C-leucine absorption, distribution, metabolism and excretion (ADME) study in adult Sprague–Dawley rat reveals β-hydroxy-β-methylbutyrate as a metabolite
por: Lee, Anthony J., et al.
Publicado: (2015)

The Effect of Dietary Leucine Supplementation on Antioxidant Capacity and Meat Quality of Finishing Pigs under Heat Stress
por: Yin, Yunju, et al.
Publicado: (2022)

Myokine interleukin-15 expression profile is different in suckling and weaning piglets
por: Duan, Yehui, et al.
Publicado: (2015)

Long-Term Protein Restriction Modulates Lipid Metabolism in White Adipose Tissues and Alters Colonic Microbiota of Shaziling Pigs
por: Zheng, Jie, et al.
Publicado: (2022)

Different effects of dietary β-hydroxy-β-methylbutyrate on composition of fatty acid and free amino acid, and fatty metabolism in the different muscles of broilers
por: Wan, Mengliao, et al.
Publicado: (2023)

Culturing C2C12 myotubes on micromolded gelatin hydrogels accelerates myotube maturation
por: Denes, Lance T., et al.
Publicado: (2019)

The Effect of 12 Weeks of β-Hydroxy-β-Methyl-Butyrate Supplementation after Liver Transplantation: A Pilot Randomized Controlled Study
por: Lattanzi, Barbara, et al.
Publicado: (2019)

Irisin prevents dexamethasone-induced atrophy in C2C12 myotubes
por: Chang, Jae Seung, et al.
Publicado: (2020)

Pyropia yezoensis Protein Prevents Dexamethasone-Induced Myotube Atrophy in C2C12 Myotubes
por: Lee, Min-Kyeong, et al.
Publicado: (2018)

Myristic acid selectively augments β‐tubulin levels in C2C12 myotubes via diacylglycerol kinase δ
por: Sakai, Hiromichi, et al.
Publicado: (2022)

Effects of Dietary Tea Powder on the Growth Performance, Carcass Traits, and Meat Quality of Tibetan Pig × Bama Miniature Pigs
por: Yan, Zhaoming, et al.
Publicado: (2021)

A metabolite of leucine (β-hydroxy-β-methylbutyrate) given to sows during pregnancy alters bone development of their newborn offspring by hormonal modulation
por: Blicharski, Tomasz, et al.
Publicado: (2017)

Dietary Beta-Hydroxy-Beta-Methyl Butyrate Supplementation Affects Growth, Carcass Characteristics, Meat Quality, and Serum Metabolomics Profile in Broiler Chickens
por: Tang, Zhiyi, et al.
Publicado: (2021)

Protective Effect of Pyropia yezoensis Peptide on Dexamethasone-Induced Myotube Atrophy in C2C12 Myotubes
por: Lee, Min-Kyeong, et al.
Publicado: (2019)

PGC-1α and PGC-1β Increase Protein Synthesis via ERRα in C2C12 Myotubes
por: Brown, Erin L., et al.
Publicado: (2018)

The actions of exogenous leucine on mTOR signalling and amino acid transporters in human myotubes
por: Gran, Petra, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_mbs9nu31kkd2ui8esbekbbep45