Mitochondrial metabolic study guided by proteomics analysis in hepatocellular carcinoma cells surviving long-term incubation with the highest dose of sorafenib

Sorafenib is the standard first-line systemic therapy for hepatocellular carcinoma (HCC). However, the low objective response rates in clinical studies suggest the existence of certain HCC cells that are inherently insensitive to sorafenib. To understand the molecular basis of insensitivity of HCC c...

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Detalles Bibliográficos
Autores principales: Bai, Jing, Liu, Ziqi, Liu, Jiang, Zhang, Saihang, Tian, Yuan, Zhang, Yueshan, Ren, Leiming, Kong, Dezhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949094/
https://www.ncbi.nlm.nih.gov/pubmed/31881007
http://dx.doi.org/10.18632/aging.102582

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