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Circadian clock associates with tumor microenvironment in thoracic cancers
The application of cancer chronotherapy is to treat cancers based on at specific times during circadian rhythms. Previous studies have characterized the impact of circadian clock on tumorigenesis and specific immune cells. Here, by using multi-omics computation techniques, we systematically characte...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949103/ https://www.ncbi.nlm.nih.gov/pubmed/31881010 http://dx.doi.org/10.18632/aging.102450 |
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author | Yang, Yong Yuan, Guangda Xie, Hongya Wei, Tengteng Zhu, Donglin Cui, Jianyong Liu, Xiaoqiang Shen, Rongming Zhu, Yimeng Yang, Xuefang |
author_facet | Yang, Yong Yuan, Guangda Xie, Hongya Wei, Tengteng Zhu, Donglin Cui, Jianyong Liu, Xiaoqiang Shen, Rongming Zhu, Yimeng Yang, Xuefang |
author_sort | Yang, Yong |
collection | PubMed |
description | The application of cancer chronotherapy is to treat cancers based on at specific times during circadian rhythms. Previous studies have characterized the impact of circadian clock on tumorigenesis and specific immune cells. Here, by using multi-omics computation techniques, we systematically characterized the distinct roles of core circadian clock genes in thoracic cancers including lung adenocarcinoma, lung squamous cell carcinoma, and esophageal carcinoma. Strikingly, a wide range of core clock genes are epigenetically altered in lung adenocarcinomas and lung squamous cell carcinomas but not esophageal carcinomas. Further cancer hallmark analysis reveals that several core clock genes highly correlate with apoptosis and cell cycle such as RORA and PER2. Interestingly, our results reveal that CD4 and CD8 T cells are correlated with core clock molecules especially in lung adenocarcinomas and lung squamous cell carcinomas, indicating that chrono-immunotherapy may serve as a candidate option for future cancer management. |
format | Online Article Text |
id | pubmed-6949103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-69491032020-01-13 Circadian clock associates with tumor microenvironment in thoracic cancers Yang, Yong Yuan, Guangda Xie, Hongya Wei, Tengteng Zhu, Donglin Cui, Jianyong Liu, Xiaoqiang Shen, Rongming Zhu, Yimeng Yang, Xuefang Aging (Albany NY) Research Paper The application of cancer chronotherapy is to treat cancers based on at specific times during circadian rhythms. Previous studies have characterized the impact of circadian clock on tumorigenesis and specific immune cells. Here, by using multi-omics computation techniques, we systematically characterized the distinct roles of core circadian clock genes in thoracic cancers including lung adenocarcinoma, lung squamous cell carcinoma, and esophageal carcinoma. Strikingly, a wide range of core clock genes are epigenetically altered in lung adenocarcinomas and lung squamous cell carcinomas but not esophageal carcinomas. Further cancer hallmark analysis reveals that several core clock genes highly correlate with apoptosis and cell cycle such as RORA and PER2. Interestingly, our results reveal that CD4 and CD8 T cells are correlated with core clock molecules especially in lung adenocarcinomas and lung squamous cell carcinomas, indicating that chrono-immunotherapy may serve as a candidate option for future cancer management. Impact Journals 2019-12-23 /pmc/articles/PMC6949103/ /pubmed/31881010 http://dx.doi.org/10.18632/aging.102450 Text en Copyright © 2019 Yang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Yang, Yong Yuan, Guangda Xie, Hongya Wei, Tengteng Zhu, Donglin Cui, Jianyong Liu, Xiaoqiang Shen, Rongming Zhu, Yimeng Yang, Xuefang Circadian clock associates with tumor microenvironment in thoracic cancers |
title | Circadian clock associates with tumor microenvironment in thoracic cancers |
title_full | Circadian clock associates with tumor microenvironment in thoracic cancers |
title_fullStr | Circadian clock associates with tumor microenvironment in thoracic cancers |
title_full_unstemmed | Circadian clock associates with tumor microenvironment in thoracic cancers |
title_short | Circadian clock associates with tumor microenvironment in thoracic cancers |
title_sort | circadian clock associates with tumor microenvironment in thoracic cancers |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949103/ https://www.ncbi.nlm.nih.gov/pubmed/31881010 http://dx.doi.org/10.18632/aging.102450 |
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