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Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling

Secreted R-spondin1-4 proteins (RSPO1-4) orchestrate stem cell renewal and tissue homeostasis by potentiating Wnt/β-catenin signaling. RSPOs induce the turnover of negative Wnt regulators RNF43 and ZNRF3 through a process that requires RSPO interactions with Leucine-rich repeat-containing G-protein...

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Detalles Bibliográficos
Autores principales:	Luca, Vincent C., Miao, Yi, Li, Xingnan, Hollander, Michael J., Kuo, Calvin J., Garcia, K. Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949110/ https://www.ncbi.nlm.nih.gov/pubmed/31914456 http://dx.doi.org/10.1371/journal.pone.0226928

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