Cargando…

Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus

Despite the availability of highly effective direct-acting antiviral (DAA) regimens for the treatment of hepatitis C virus (HCV) infections, sustained viral response (SVR) rates remain suboptimal for difficult-to-treat patient populations such as those with HCV genotype 3, cirrhosis or prior treatme...

Descripción completa

Detalles Bibliográficos
Autores principales:	Good, Steven S., Moussa, Adel, Zhou, Xiao-Jian, Pietropaolo, Keith, Sommadossi, Jean-Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949113/ https://www.ncbi.nlm.nih.gov/pubmed/31914458 http://dx.doi.org/10.1371/journal.pone.0227104

Ejemplares similares

1265. AT-527, an Oral Purine Nucleotide Prodrug Exhibiting Potent In Vitro Antiviral Activity Against Human Coronaviruses, Including SARS-CoV-2
por: Good, Steven S, et al.
Publicado: (2020)

169. AT-752, an Oral Guanosine Nucleotide Prodrug, Exhibits Potent in Vitro Activity Against Flaviviruses and Prevents Disease Progression in a Dengue Mouse Model
por: Good, Steven S, et al.
Publicado: (2020)

AT-527, a Double Prodrug of a Guanosine Nucleotide Analog, Is a Potent Inhibitor of SARS-CoV-2 In Vitro and a Promising Oral Antiviral for Treatment of COVID-19
por: Good, Steven S., et al.
Publicado: (2021)

Safety, Pharmacokinetics, and Antiviral Activity of AT-527, a Novel Purine Nucleotide Prodrug, in Hepatitis C Virus-Infected Subjects with or without Cirrhosis
por: Berliba, Elina, et al.
Publicado: (2019)

Discovery of a Series of Potent and Selective Nucleotide Prodrug Inhibitors of Respiratory Syncytial Virus (RSV) Replication
por: Good, Steven, et al.
Publicado: (2017)

AT-752, a double prodrug of a guanosine nucleotide analog, inhibits yellow fever virus in a hamster model
por: Lin, Kai, et al.
Publicado: (2022)

Evaluation of AT-752, a Double Prodrug of a Guanosine Nucleotide Analog with In Vitro and In Vivo Activity against Dengue and Other Flaviviruses
por: Good, Steven S., et al.
Publicado: (2021)

A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
por: Shannon, Ashleigh, et al.
Publicado: (2022)

DNAzyme-mediated catalysis with only guanosine and cytidine nucleotides
por: Schlosser, Kenny, et al.
Publicado: (2009)

The Role of the Guanosine Nucleotide-Binding Protein in the Corpus Luteum
por: Billhaq, Dody Houston, et al.
Publicado: (2021)

Don Giovanni KV 527
por: Mozart, Wolfgang Amadeus, 1756-1791
Publicado: (1992)

Guanosine inhibits hepatitis C virus replication and increases indel frequencies, associated with altered intracellular nucleotide pools
por: Sabariegos, Rosario, et al.
Publicado: (2022)

Potent Chlorambucil-Platinum(IV) Prodrugs
por: Aputen, Angelico D., et al.
Publicado: (2022)

The Bispecific Tumor Antigen-Conditional 4–1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies
por: Nelson, Michelle H., et al.
Publicado: (2023)

Oral bemnifosbuvir (AT-527) vs placebo in patients with mild-to-moderate COVID-19 in an outpatient setting (MORNINGSKY)
por: Horga, Arantxa, et al.
Publicado: (2023)

New Preclinical Antimalarial Drugs Potently Inhibit Hepatitis C Virus Genotype 1b RNA Replication
por: Ueda, Youki, et al.
Publicado: (2013)

Identification of a Potent Phosphoinositide 3‐Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs
por: Pirali, Tracey, et al.
Publicado: (2017)

Guanosine-Based Nucleotides, the Sons of a Lesser God in the Purinergic Signal Scenario of Excitable Tissues
por: Mancinelli, Rosa, et al.
Publicado: (2020)

Crosstalk between guanosine nucleotides regulates cellular heterogeneity in protein synthesis during nutrient limitation
por: Diez, Simon, et al.
Publicado: (2022)

MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis
por: Edwards, Rachel L., et al.
Publicado: (2017)

Correction: New Preclinical Antimalarial Drugs Potently Inhibit Hepatitis C Virus Genotype 1b RNA Replication
por: Ueda, Youki, et al.
Publicado: (2013)

Rogaratinib: A potent and selective pan‐FGFR inhibitor with broad antitumor activity in FGFR‐overexpressing preclinical cancer models
por: Grünewald, Sylvia, et al.
Publicado: (2019)

Apoptotic and anti-proliferative effect of guanosine and guanosine derivatives in HuT-78 T lymphoma cells
por: Schneider, Erich H., et al.
Publicado: (2020)

On the epigenetic role of guanosine oxidation
por: Giorgio, Marco, et al.
Publicado: (2019)

Cyclooxygenase-Inhibiting Platinum(IV) Prodrugs with Potent Anticancer Activity
por: Khoury, Aleen, et al.
Publicado: (2022)

Disulfide-containing polymer delivery of C527 and a Platinum(IV) prodrug selectively inhibited protein ubiquitination and tumor growth on cisplatin resistant and patient-derived liver cancer models
por: Shang, Kun, et al.
Publicado: (2023)

The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function
por: Lorenzo-Martín, L. Francisco, et al.
Publicado: (2022)

527 Evaluation of the September Epidemic of Asthma Exacerbation in Children in Our Practice
por: Nemeth II, Agnes
Publicado: (2012)

Association between microRNA-527 and glypican-3 in hepatocellular carcinoma
por: Nomura, Kei, et al.
Publicado: (2021)

Nucleoside analogs NM107 and AT-527 are antiviral against rubella virus
por: Dittmar, Mark, et al.
Publicado: (2023)

Extracellular Guanosine 5′-Triphosphate Induces Human Muscle Satellite Cells to Release Exosomes Stuffed With Guanosine
por: Pietrangelo, Tiziana, et al.
Publicado: (2018)

Preclinical disposition of MGS0274 besylate, a prodrug of a potent group II metabotropic glutamate receptor agonist MGS0008 for the treatment of schizophrenia
por: Kinoshita, Kohnosuke, et al.
Publicado: (2019)

Clickable prodrugs bearing potent and hydrolytically cleavable nicotinamide phosphoribosyltransferase inhibitors
por: Sadrerafi, Keivan, et al.
Publicado: (2018)

O-2-Alkylated Cytosine Acyclic Nucleoside Phosphonamidate Prodrugs Display Pan-Genotype Antiviral Activity against African Swine Fever Virus
por: Goulding, Leah V., et al.
Publicado: (2022)

Guanosine regulates adenosine levels in the kidney
por: Jackson, Edwin K., et al.
Publicado: (2014)

Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment
por: Feng, Joy Y., et al.
Publicado: (2018)

Trio sonatas BWV 525, 526 and 527 ; Prelude and fugue BWV 543
por: Bach, Johann Sebastian, 1685-1750
Publicado: (1993)

527 Practical Use of Biomarkers During Nutritional Support of Pediatric Burn Patients
por: Shiel, Jennifer, et al.
Publicado: (2022)

527 Academic Medical Center Clinical Research Professional Recruitment, Retention and Diversity
por: Jones, Carolynn Thomas, et al.
Publicado: (2022)

EX-527 Prevents the Progression of High-Fat Diet-Induced Hepatic Steatosis and Fibrosis by Upregulating SIRT4 in Zucker Rats
por: Kundu, Amit, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ifi9021j2pvh32k46ljpji5th5