Dichloroacetate restores colorectal cancer chemosensitivity through the p53/miR-149-3p/PDK2-mediated glucose metabolic pathway

The development of chemoresistance remains a major challenge that accounts for colorectal cancer (CRC) lethality. Dichloroacetate (DCA) was originally used as a metabolic regulator in the treatment of metabolic diseases; here, DCA was assayed to identify the mechanisms underlying the chemoresistance...

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Detalles Bibliográficos
Autores principales: Liang, Yu, Hou, Lidan, Li, Linjing, Li, Lei, Zhu, Liming, Wang, Yu, Huang, Xin, Hou, Yichao, Zhu, Danxi, Zou, Huimin, Gu, Yan, Weng, Xiaoling, Wang, Yingying, Li, Yue, Wu, Tianqi, Yao, Mengfei, Gross, Isabelle, Gaiddon, Christian, Luo, Meng, Wang, Jianhua, Meng, Xiangjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949190/
https://www.ncbi.nlm.nih.gov/pubmed/31597953
http://dx.doi.org/10.1038/s41388-019-1035-8

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