Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis

Psoriasis is an inflammatory skin disease with strong neutrophil (PMN) infiltration and high levels of the antimicrobial peptide, LL37. LL37 in complex with DNA and RNA is thought to initiate disease exacerbation via plasmacytoid dendritic cells. However, the source of nucleic acids supposed to star...

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Detalles Bibliográficos
Autores principales: Herster, Franziska, Bittner, Zsofia, Archer, Nathan K., Dickhöfer, Sabine, Eisel, David, Eigenbrod, Tatjana, Knorpp, Thomas, Schneiderhan-Marra, Nicole, Löffler, Markus W., Kalbacher, Hubert, Vierbuchen, Tim, Heine, Holger, Miller, Lloyd S., Hartl, Dominik, Freund, Lukas, Schäkel, Knut, Heister, Martin, Ghoreschi, Kamran, Weber, Alexander N. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949246/
https://www.ncbi.nlm.nih.gov/pubmed/31913271
http://dx.doi.org/10.1038/s41467-019-13756-4

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