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Structural analysis of retinal blood vessels in patients with COPD during a pulmonary rehabilitation program

Cardiovascular diseases are frequently present in chronic obstructive pulmonary disease (COPD). Population-based studies found associations between retinal vessel diameters and cardiovascular health, but it is unknown whether this also applies to COPD patients. Therefore, we measured retinal vessel...

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Autores principales: Vaes, Anouk W., Spruit, Martijn A., Van Keer, Karel, Barbosa-Breda, João, Wouters, Emiel F. M., Franssen, Frits M. E., Theunis, Jan, De Boever, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949286/
https://www.ncbi.nlm.nih.gov/pubmed/31913345
http://dx.doi.org/10.1038/s41598-019-56997-5
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author Vaes, Anouk W.
Spruit, Martijn A.
Van Keer, Karel
Barbosa-Breda, João
Wouters, Emiel F. M.
Franssen, Frits M. E.
Theunis, Jan
De Boever, Patrick
author_facet Vaes, Anouk W.
Spruit, Martijn A.
Van Keer, Karel
Barbosa-Breda, João
Wouters, Emiel F. M.
Franssen, Frits M. E.
Theunis, Jan
De Boever, Patrick
author_sort Vaes, Anouk W.
collection PubMed
description Cardiovascular diseases are frequently present in chronic obstructive pulmonary disease (COPD). Population-based studies found associations between retinal vessel diameters and cardiovascular health, but it is unknown whether this also applies to COPD patients. Therefore, we measured retinal vessel diameters in COPD patients and aimed to determine the association with cardiovascular risk factors, lung function, and functional outcomes. In addition, we investigated whether an exercise-based pulmonary rehabilitation (PR) program would change retinal vessel diameters, as a proxy for improved microvascular health. Demographics and clinical characteristics, including pulmonary function, exercise capacity, blood pressure, blood measurements and level of systemic inflammation were obtained from 246 patients during routine assessment before and after PR. Retinal vessel diameters were measured from digital retinal images. Older age and higher systolic blood pressure were associated with narrower retinal arterioles (β: −0.224; p = 0.042 and β: −0.136; p < 0.001, respectively). Older age, higher systolic blood pressure and lower level of systemic inflammation were associated with narrower retinal venules (β: −0.654; −0.229; and −13.767, respectively; p < 0.05). No associations were found between retinal vessel diameters and lung function parameters or functional outcomes. After PR, no significant changes in retinal venular or arteriolar diameter were found. To conclude, retinal vessel diameters of COPD patients were significantly associated with systolic blood pressure and systemic inflammation, whilst there was no evidence for an association with lung function parameters, functional outcomes or other cardiovascular risk factors. Furthermore, an exercise-based PR program did not affect retinal vessel diameter.
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spelling pubmed-69492862020-01-13 Structural analysis of retinal blood vessels in patients with COPD during a pulmonary rehabilitation program Vaes, Anouk W. Spruit, Martijn A. Van Keer, Karel Barbosa-Breda, João Wouters, Emiel F. M. Franssen, Frits M. E. Theunis, Jan De Boever, Patrick Sci Rep Article Cardiovascular diseases are frequently present in chronic obstructive pulmonary disease (COPD). Population-based studies found associations between retinal vessel diameters and cardiovascular health, but it is unknown whether this also applies to COPD patients. Therefore, we measured retinal vessel diameters in COPD patients and aimed to determine the association with cardiovascular risk factors, lung function, and functional outcomes. In addition, we investigated whether an exercise-based pulmonary rehabilitation (PR) program would change retinal vessel diameters, as a proxy for improved microvascular health. Demographics and clinical characteristics, including pulmonary function, exercise capacity, blood pressure, blood measurements and level of systemic inflammation were obtained from 246 patients during routine assessment before and after PR. Retinal vessel diameters were measured from digital retinal images. Older age and higher systolic blood pressure were associated with narrower retinal arterioles (β: −0.224; p = 0.042 and β: −0.136; p < 0.001, respectively). Older age, higher systolic blood pressure and lower level of systemic inflammation were associated with narrower retinal venules (β: −0.654; −0.229; and −13.767, respectively; p < 0.05). No associations were found between retinal vessel diameters and lung function parameters or functional outcomes. After PR, no significant changes in retinal venular or arteriolar diameter were found. To conclude, retinal vessel diameters of COPD patients were significantly associated with systolic blood pressure and systemic inflammation, whilst there was no evidence for an association with lung function parameters, functional outcomes or other cardiovascular risk factors. Furthermore, an exercise-based PR program did not affect retinal vessel diameter. Nature Publishing Group UK 2020-01-08 /pmc/articles/PMC6949286/ /pubmed/31913345 http://dx.doi.org/10.1038/s41598-019-56997-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Vaes, Anouk W.
Spruit, Martijn A.
Van Keer, Karel
Barbosa-Breda, João
Wouters, Emiel F. M.
Franssen, Frits M. E.
Theunis, Jan
De Boever, Patrick
Structural analysis of retinal blood vessels in patients with COPD during a pulmonary rehabilitation program
title Structural analysis of retinal blood vessels in patients with COPD during a pulmonary rehabilitation program
title_full Structural analysis of retinal blood vessels in patients with COPD during a pulmonary rehabilitation program
title_fullStr Structural analysis of retinal blood vessels in patients with COPD during a pulmonary rehabilitation program
title_full_unstemmed Structural analysis of retinal blood vessels in patients with COPD during a pulmonary rehabilitation program
title_short Structural analysis of retinal blood vessels in patients with COPD during a pulmonary rehabilitation program
title_sort structural analysis of retinal blood vessels in patients with copd during a pulmonary rehabilitation program
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949286/
https://www.ncbi.nlm.nih.gov/pubmed/31913345
http://dx.doi.org/10.1038/s41598-019-56997-5
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