ULK1 phosphorylates Exo70 to suppress breast cancer metastasis

Increased expression of protein kinase ULK1 was reported to negatively correlate with breast cancer metastasis. Here we report that ULK1 suppresses the migration and invasion of human breast cancer cells. The suppressive effect is mediated through direct phosphorylation of Exo70, a key component of...

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Detalles Bibliográficos
Autores principales: Mao, Liyuan, Zhan, Yan-yan, Wu, Bin, Yu, Qiang, Xu, Liang, Hong, Xiaoting, Zhong, Linhai, Mi, Panying, Xiao, Li, Wang, Xinquan, Cao, Hanwei, Zhang, Wenqing, Chen, Binbin, Xiang, Jingzhou, Mei, Kunrong, Radhakrishnan, Ravi, Guo, Wei, Hu, Tianhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949295/
https://www.ncbi.nlm.nih.gov/pubmed/31913283
http://dx.doi.org/10.1038/s41467-019-13923-7

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