Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

Interleukin(IL)-1β, a pro-inflammatory cytokine, was elevated and participates in periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical evidence, but also the increased IL-1β triggers a series of inflammatory reactions and promotes bone resorption. Currently, IL-1β...

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Autores principales: Cheng, Ran, Wu, Zhiwu, Li, Mingming, Shao, Meiying, Hu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949296/
https://www.ncbi.nlm.nih.gov/pubmed/31900383
http://dx.doi.org/10.1038/s41368-019-0068-8
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author Cheng, Ran
Wu, Zhiwu
Li, Mingming
Shao, Meiying
Hu, Tao
author_facet Cheng, Ran
Wu, Zhiwu
Li, Mingming
Shao, Meiying
Hu, Tao
author_sort Cheng, Ran
collection PubMed
description Interleukin(IL)-1β, a pro-inflammatory cytokine, was elevated and participates in periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical evidence, but also the increased IL-1β triggers a series of inflammatory reactions and promotes bone resorption. Currently, IL-1β blockage has been therapeutic strategies for autoimmune and autoinflammatory diseases such as rheumatoid arthritis, cryopyrin-associated periodic syndromes, gout and type II diabetes mellitus. It is speculated that IL-1β be a potential therapeutic target for periodontitis. The review focuses on the production, mechanism, present treatments and future potential strategies for IL-1β in periodontitis.
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spelling pubmed-69492962020-01-13 Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review Cheng, Ran Wu, Zhiwu Li, Mingming Shao, Meiying Hu, Tao Int J Oral Sci Review Article Interleukin(IL)-1β, a pro-inflammatory cytokine, was elevated and participates in periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical evidence, but also the increased IL-1β triggers a series of inflammatory reactions and promotes bone resorption. Currently, IL-1β blockage has been therapeutic strategies for autoimmune and autoinflammatory diseases such as rheumatoid arthritis, cryopyrin-associated periodic syndromes, gout and type II diabetes mellitus. It is speculated that IL-1β be a potential therapeutic target for periodontitis. The review focuses on the production, mechanism, present treatments and future potential strategies for IL-1β in periodontitis. Nature Publishing Group UK 2020-01-02 /pmc/articles/PMC6949296/ /pubmed/31900383 http://dx.doi.org/10.1038/s41368-019-0068-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Cheng, Ran
Wu, Zhiwu
Li, Mingming
Shao, Meiying
Hu, Tao
Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review
title Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review
title_full Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review
title_fullStr Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review
title_full_unstemmed Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review
title_short Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review
title_sort interleukin-1β is a potential therapeutic target for periodontitis: a narrative review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949296/
https://www.ncbi.nlm.nih.gov/pubmed/31900383
http://dx.doi.org/10.1038/s41368-019-0068-8
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