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Immunoglobulin G4-related Liver Disease Overlapping with Non-alcoholic Steatohepatitis That Was Diagnosed Simultaneously with Autoimmune Pancreatitis: A Case Report and Review of the Literature

A 70-year-old woman was referred to our hospital due to symptoms of dry eyes, dry mouth, and epigastric pain. Computed tomography showed distal pancreatic swelling, liver edge dullness and surface irregularities. Serum anti-nuclear antibody titers, immunoglobulin G and IgG4 levels were elevated. Aut...

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Autores principales: Matsumoto, Kotaro, Kikuchi, Kentaro, Kuniyoshi, Noriyuki, Tsunashima, Hiromichi, Sekine, Katsunori, Mabuchi, Masatoshi, Doi, Shinpei, Zen, Yoh, Miyakawa, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949448/
https://www.ncbi.nlm.nih.gov/pubmed/31366800
http://dx.doi.org/10.2169/internalmedicine.3204-19
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author Matsumoto, Kotaro
Kikuchi, Kentaro
Kuniyoshi, Noriyuki
Tsunashima, Hiromichi
Sekine, Katsunori
Mabuchi, Masatoshi
Doi, Shinpei
Zen, Yoh
Miyakawa, Hiroshi
author_facet Matsumoto, Kotaro
Kikuchi, Kentaro
Kuniyoshi, Noriyuki
Tsunashima, Hiromichi
Sekine, Katsunori
Mabuchi, Masatoshi
Doi, Shinpei
Zen, Yoh
Miyakawa, Hiroshi
author_sort Matsumoto, Kotaro
collection PubMed
description A 70-year-old woman was referred to our hospital due to symptoms of dry eyes, dry mouth, and epigastric pain. Computed tomography showed distal pancreatic swelling, liver edge dullness and surface irregularities. Serum anti-nuclear antibody titers, immunoglobulin G and IgG4 levels were elevated. Autoimmune pancreatitis (AIP) was diagnosed based on endoscopic findings and a histopathological examination. Her AIP improved after starting prednisolone treatment. A liver biopsy revealed interface hepatitis with lymphoplasmacyte and IgG4-positive plasma cell infiltration. In addition, non-alcoholic steatohepatitis (NASH) was diagnosed based on the presence of parenchymal steatosis, ballooning hepatocytes, and pericellular fibrosis. We experienced a unique liver disease case showing IgG4-related liver disease overlapping with NASH.
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spelling pubmed-69494482020-01-09 Immunoglobulin G4-related Liver Disease Overlapping with Non-alcoholic Steatohepatitis That Was Diagnosed Simultaneously with Autoimmune Pancreatitis: A Case Report and Review of the Literature Matsumoto, Kotaro Kikuchi, Kentaro Kuniyoshi, Noriyuki Tsunashima, Hiromichi Sekine, Katsunori Mabuchi, Masatoshi Doi, Shinpei Zen, Yoh Miyakawa, Hiroshi Intern Med Case Report A 70-year-old woman was referred to our hospital due to symptoms of dry eyes, dry mouth, and epigastric pain. Computed tomography showed distal pancreatic swelling, liver edge dullness and surface irregularities. Serum anti-nuclear antibody titers, immunoglobulin G and IgG4 levels were elevated. Autoimmune pancreatitis (AIP) was diagnosed based on endoscopic findings and a histopathological examination. Her AIP improved after starting prednisolone treatment. A liver biopsy revealed interface hepatitis with lymphoplasmacyte and IgG4-positive plasma cell infiltration. In addition, non-alcoholic steatohepatitis (NASH) was diagnosed based on the presence of parenchymal steatosis, ballooning hepatocytes, and pericellular fibrosis. We experienced a unique liver disease case showing IgG4-related liver disease overlapping with NASH. The Japanese Society of Internal Medicine 2019-07-31 2019-12-15 /pmc/articles/PMC6949448/ /pubmed/31366800 http://dx.doi.org/10.2169/internalmedicine.3204-19 Text en Copyright © 2019 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Matsumoto, Kotaro
Kikuchi, Kentaro
Kuniyoshi, Noriyuki
Tsunashima, Hiromichi
Sekine, Katsunori
Mabuchi, Masatoshi
Doi, Shinpei
Zen, Yoh
Miyakawa, Hiroshi
Immunoglobulin G4-related Liver Disease Overlapping with Non-alcoholic Steatohepatitis That Was Diagnosed Simultaneously with Autoimmune Pancreatitis: A Case Report and Review of the Literature
title Immunoglobulin G4-related Liver Disease Overlapping with Non-alcoholic Steatohepatitis That Was Diagnosed Simultaneously with Autoimmune Pancreatitis: A Case Report and Review of the Literature
title_full Immunoglobulin G4-related Liver Disease Overlapping with Non-alcoholic Steatohepatitis That Was Diagnosed Simultaneously with Autoimmune Pancreatitis: A Case Report and Review of the Literature
title_fullStr Immunoglobulin G4-related Liver Disease Overlapping with Non-alcoholic Steatohepatitis That Was Diagnosed Simultaneously with Autoimmune Pancreatitis: A Case Report and Review of the Literature
title_full_unstemmed Immunoglobulin G4-related Liver Disease Overlapping with Non-alcoholic Steatohepatitis That Was Diagnosed Simultaneously with Autoimmune Pancreatitis: A Case Report and Review of the Literature
title_short Immunoglobulin G4-related Liver Disease Overlapping with Non-alcoholic Steatohepatitis That Was Diagnosed Simultaneously with Autoimmune Pancreatitis: A Case Report and Review of the Literature
title_sort immunoglobulin g4-related liver disease overlapping with non-alcoholic steatohepatitis that was diagnosed simultaneously with autoimmune pancreatitis: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949448/
https://www.ncbi.nlm.nih.gov/pubmed/31366800
http://dx.doi.org/10.2169/internalmedicine.3204-19
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