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Polymorph evolution during crystal growth studied by 3D electron diffraction
3D electron diffraction (3DED) has been used to follow polymorph evolution in the crystallization of glycine from aqueous solution. The three polymorphs of glycine which exist under ambient conditions follow the stability order β < α < γ. The least stable β polymorph forms within the first 3 m...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949601/ https://www.ncbi.nlm.nih.gov/pubmed/31949899 http://dx.doi.org/10.1107/S2052252519016105 |
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author | Broadhurst, Edward T. Xu, Hongyi Clabbers, Max T. B. Lightowler, Molly Nudelman, Fabio Zou, Xiaodong Parsons, Simon |
author_facet | Broadhurst, Edward T. Xu, Hongyi Clabbers, Max T. B. Lightowler, Molly Nudelman, Fabio Zou, Xiaodong Parsons, Simon |
author_sort | Broadhurst, Edward T. |
collection | PubMed |
description | 3D electron diffraction (3DED) has been used to follow polymorph evolution in the crystallization of glycine from aqueous solution. The three polymorphs of glycine which exist under ambient conditions follow the stability order β < α < γ. The least stable β polymorph forms within the first 3 min, but this begins to yield the α-form after only 1 min more. Both structures could be determined from continuous rotation electron diffraction data collected in less than 20 s on crystals of thickness ∼100 nm. Even though the γ-form is thermodynamically the most stable polymorph, kinetics favour the α-form, which dominates after prolonged standing. In the same sample, some β and one crystallite of the γ polymorph were also observed. |
format | Online Article Text |
id | pubmed-6949601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-69496012020-01-16 Polymorph evolution during crystal growth studied by 3D electron diffraction Broadhurst, Edward T. Xu, Hongyi Clabbers, Max T. B. Lightowler, Molly Nudelman, Fabio Zou, Xiaodong Parsons, Simon IUCrJ Research Letters 3D electron diffraction (3DED) has been used to follow polymorph evolution in the crystallization of glycine from aqueous solution. The three polymorphs of glycine which exist under ambient conditions follow the stability order β < α < γ. The least stable β polymorph forms within the first 3 min, but this begins to yield the α-form after only 1 min more. Both structures could be determined from continuous rotation electron diffraction data collected in less than 20 s on crystals of thickness ∼100 nm. Even though the γ-form is thermodynamically the most stable polymorph, kinetics favour the α-form, which dominates after prolonged standing. In the same sample, some β and one crystallite of the γ polymorph were also observed. International Union of Crystallography 2020-01-01 /pmc/articles/PMC6949601/ /pubmed/31949899 http://dx.doi.org/10.1107/S2052252519016105 Text en © Broadhurst et al. 2020 http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Research Letters Broadhurst, Edward T. Xu, Hongyi Clabbers, Max T. B. Lightowler, Molly Nudelman, Fabio Zou, Xiaodong Parsons, Simon Polymorph evolution during crystal growth studied by 3D electron diffraction |
title | Polymorph evolution during crystal growth studied by 3D electron diffraction |
title_full | Polymorph evolution during crystal growth studied by 3D electron diffraction |
title_fullStr | Polymorph evolution during crystal growth studied by 3D electron diffraction |
title_full_unstemmed | Polymorph evolution during crystal growth studied by 3D electron diffraction |
title_short | Polymorph evolution during crystal growth studied by 3D electron diffraction |
title_sort | polymorph evolution during crystal growth studied by 3d electron diffraction |
topic | Research Letters |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949601/ https://www.ncbi.nlm.nih.gov/pubmed/31949899 http://dx.doi.org/10.1107/S2052252519016105 |
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