Cargando…

Polymorph evolution during crystal growth studied by 3D electron diffraction

3D electron diffraction (3DED) has been used to follow polymorph evolution in the crystallization of glycine from aqueous solution. The three polymorphs of glycine which exist under ambient conditions follow the stability order β < α < γ. The least stable β polymorph forms within the first 3 m...

Descripción completa

Detalles Bibliográficos
Autores principales: Broadhurst, Edward T., Xu, Hongyi, Clabbers, Max T. B., Lightowler, Molly, Nudelman, Fabio, Zou, Xiaodong, Parsons, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949601/
https://www.ncbi.nlm.nih.gov/pubmed/31949899
http://dx.doi.org/10.1107/S2052252519016105
_version_ 1783485929507258368
author Broadhurst, Edward T.
Xu, Hongyi
Clabbers, Max T. B.
Lightowler, Molly
Nudelman, Fabio
Zou, Xiaodong
Parsons, Simon
author_facet Broadhurst, Edward T.
Xu, Hongyi
Clabbers, Max T. B.
Lightowler, Molly
Nudelman, Fabio
Zou, Xiaodong
Parsons, Simon
author_sort Broadhurst, Edward T.
collection PubMed
description 3D electron diffraction (3DED) has been used to follow polymorph evolution in the crystallization of glycine from aqueous solution. The three polymorphs of glycine which exist under ambient conditions follow the stability order β < α < γ. The least stable β polymorph forms within the first 3 min, but this begins to yield the α-form after only 1 min more. Both structures could be determined from continuous rotation electron diffraction data collected in less than 20 s on crystals of thickness ∼100 nm. Even though the γ-form is thermodynamically the most stable polymorph, kinetics favour the α-form, which dominates after prolonged standing. In the same sample, some β and one crystallite of the γ polymorph were also observed.
format Online
Article
Text
id pubmed-6949601
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher International Union of Crystallography
record_format MEDLINE/PubMed
spelling pubmed-69496012020-01-16 Polymorph evolution during crystal growth studied by 3D electron diffraction Broadhurst, Edward T. Xu, Hongyi Clabbers, Max T. B. Lightowler, Molly Nudelman, Fabio Zou, Xiaodong Parsons, Simon IUCrJ Research Letters 3D electron diffraction (3DED) has been used to follow polymorph evolution in the crystallization of glycine from aqueous solution. The three polymorphs of glycine which exist under ambient conditions follow the stability order β < α < γ. The least stable β polymorph forms within the first 3 min, but this begins to yield the α-form after only 1 min more. Both structures could be determined from continuous rotation electron diffraction data collected in less than 20 s on crystals of thickness ∼100 nm. Even though the γ-form is thermodynamically the most stable polymorph, kinetics favour the α-form, which dominates after prolonged standing. In the same sample, some β and one crystallite of the γ polymorph were also observed. International Union of Crystallography 2020-01-01 /pmc/articles/PMC6949601/ /pubmed/31949899 http://dx.doi.org/10.1107/S2052252519016105 Text en © Broadhurst et al. 2020 http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/4.0/
spellingShingle Research Letters
Broadhurst, Edward T.
Xu, Hongyi
Clabbers, Max T. B.
Lightowler, Molly
Nudelman, Fabio
Zou, Xiaodong
Parsons, Simon
Polymorph evolution during crystal growth studied by 3D electron diffraction
title Polymorph evolution during crystal growth studied by 3D electron diffraction
title_full Polymorph evolution during crystal growth studied by 3D electron diffraction
title_fullStr Polymorph evolution during crystal growth studied by 3D electron diffraction
title_full_unstemmed Polymorph evolution during crystal growth studied by 3D electron diffraction
title_short Polymorph evolution during crystal growth studied by 3D electron diffraction
title_sort polymorph evolution during crystal growth studied by 3d electron diffraction
topic Research Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949601/
https://www.ncbi.nlm.nih.gov/pubmed/31949899
http://dx.doi.org/10.1107/S2052252519016105
work_keys_str_mv AT broadhurstedwardt polymorphevolutionduringcrystalgrowthstudiedby3delectrondiffraction
AT xuhongyi polymorphevolutionduringcrystalgrowthstudiedby3delectrondiffraction
AT clabbersmaxtb polymorphevolutionduringcrystalgrowthstudiedby3delectrondiffraction
AT lightowlermolly polymorphevolutionduringcrystalgrowthstudiedby3delectrondiffraction
AT nudelmanfabio polymorphevolutionduringcrystalgrowthstudiedby3delectrondiffraction
AT zouxiaodong polymorphevolutionduringcrystalgrowthstudiedby3delectrondiffraction
AT parsonssimon polymorphevolutionduringcrystalgrowthstudiedby3delectrondiffraction