Mirolysin structures open a window on gum disease

Guevara, Rodriguez-Banqueri et al. [(2020), IUCrJ, 7, 18–29] determine crystal structures of mirolysin, a metalloprotease that helps oral pathogen Tannerella forsythia evade the human immune response. The structures provide insight into the regulation and specificity of mirolysin, and hint at how it...

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Detalles Bibliográficos
Autor principal: Radisky, Evette S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2020
Materias:
Scientific Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949602/
https://www.ncbi.nlm.nih.gov/pubmed/31949898
http://dx.doi.org/10.1107/S2052252519016968
Descripción
Sumario:Guevara, Rodriguez-Banqueri et al. [(2020), IUCrJ, 7, 18–29] determine crystal structures of mirolysin, a metalloprotease that helps oral pathogen Tannerella forsythia evade the human immune response. The structures provide insight into the regulation and specificity of mirolysin, and hint at how it might be inhibited for therapeutic effect.

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