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Allicin Improves Metabolism in High-Fat Diet-Induced Obese Mice by Modulating the Gut Microbiota

Allicin, naturally present in the bulbs of the lily family, has anticancer, blood pressure lowering, blood fat lowering and diabetes improving effects. Recent studies have shown that allicin promotes the browning of white adipocytes and reduces the weight gain of mice induced by high-fat diet. While...

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Autores principales: Shi, Xin’e, Zhou, Xiaomin, Chu, Xinyi, Wang, Jie, Xie, Baocai, Ge, Jing, Guo, Yuan, Li, Xiao, Yang, Gongshe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949904/
https://www.ncbi.nlm.nih.gov/pubmed/31810206
http://dx.doi.org/10.3390/nu11122909
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author Shi, Xin’e
Zhou, Xiaomin
Chu, Xinyi
Wang, Jie
Xie, Baocai
Ge, Jing
Guo, Yuan
Li, Xiao
Yang, Gongshe
author_facet Shi, Xin’e
Zhou, Xiaomin
Chu, Xinyi
Wang, Jie
Xie, Baocai
Ge, Jing
Guo, Yuan
Li, Xiao
Yang, Gongshe
author_sort Shi, Xin’e
collection PubMed
description Allicin, naturally present in the bulbs of the lily family, has anticancer, blood pressure lowering, blood fat lowering and diabetes improving effects. Recent studies have shown that allicin promotes the browning of white adipocytes and reduces the weight gain of mice induced by high-fat diet. While the gut microbiota has a strong relationship with obesity and energy metabolism, the effect of allicin on weight loss via gut microorganisms is still unclear. In this study, we treated obese mice induced by high-fat diet with allicin to determine its effects on fat deposition, blood metabolic parameters and intestinal morphology. Furthermore, we used high-throughput sequencing on a MiSeq Illumina platform to determine the gut microorganisms’ species. We found that allicin significantly reduced the weight gain of obese mice by promoting lipolysis and thermogenesis, as well as blood metabolism and intestinal morphology, and suppressing hepatic lipid synthesis and transport. In addition, allicin changed the composition of the intestinal microbiota and increased the proportion of beneficial bacteria. In conclusion, our study showed that allicin improves metabolism in high-fat induced obese mice by modulating the gut microbiota. Our findings provide a theoretical basis for further elucidation of the weight loss mechanism of allicin.
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spelling pubmed-69499042020-01-16 Allicin Improves Metabolism in High-Fat Diet-Induced Obese Mice by Modulating the Gut Microbiota Shi, Xin’e Zhou, Xiaomin Chu, Xinyi Wang, Jie Xie, Baocai Ge, Jing Guo, Yuan Li, Xiao Yang, Gongshe Nutrients Article Allicin, naturally present in the bulbs of the lily family, has anticancer, blood pressure lowering, blood fat lowering and diabetes improving effects. Recent studies have shown that allicin promotes the browning of white adipocytes and reduces the weight gain of mice induced by high-fat diet. While the gut microbiota has a strong relationship with obesity and energy metabolism, the effect of allicin on weight loss via gut microorganisms is still unclear. In this study, we treated obese mice induced by high-fat diet with allicin to determine its effects on fat deposition, blood metabolic parameters and intestinal morphology. Furthermore, we used high-throughput sequencing on a MiSeq Illumina platform to determine the gut microorganisms’ species. We found that allicin significantly reduced the weight gain of obese mice by promoting lipolysis and thermogenesis, as well as blood metabolism and intestinal morphology, and suppressing hepatic lipid synthesis and transport. In addition, allicin changed the composition of the intestinal microbiota and increased the proportion of beneficial bacteria. In conclusion, our study showed that allicin improves metabolism in high-fat induced obese mice by modulating the gut microbiota. Our findings provide a theoretical basis for further elucidation of the weight loss mechanism of allicin. MDPI 2019-12-02 /pmc/articles/PMC6949904/ /pubmed/31810206 http://dx.doi.org/10.3390/nu11122909 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shi, Xin’e
Zhou, Xiaomin
Chu, Xinyi
Wang, Jie
Xie, Baocai
Ge, Jing
Guo, Yuan
Li, Xiao
Yang, Gongshe
Allicin Improves Metabolism in High-Fat Diet-Induced Obese Mice by Modulating the Gut Microbiota
title Allicin Improves Metabolism in High-Fat Diet-Induced Obese Mice by Modulating the Gut Microbiota
title_full Allicin Improves Metabolism in High-Fat Diet-Induced Obese Mice by Modulating the Gut Microbiota
title_fullStr Allicin Improves Metabolism in High-Fat Diet-Induced Obese Mice by Modulating the Gut Microbiota
title_full_unstemmed Allicin Improves Metabolism in High-Fat Diet-Induced Obese Mice by Modulating the Gut Microbiota
title_short Allicin Improves Metabolism in High-Fat Diet-Induced Obese Mice by Modulating the Gut Microbiota
title_sort allicin improves metabolism in high-fat diet-induced obese mice by modulating the gut microbiota
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949904/
https://www.ncbi.nlm.nih.gov/pubmed/31810206
http://dx.doi.org/10.3390/nu11122909
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