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Comparative Analysis of Roseoloviruses in Humans, Pigs, Mice, and Other Species

Viruses of the genus Roseolovirus belong to the subfamily Betaherpesvirinae, family Herpesviridae. Roseoloviruses have been studied in humans, mice and pigs, but they are likely also present in other species. This is the first comparative analysis of roseoloviruses in humans and animals. The human r...

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Autores principales: Denner, Joachim, Bigley, Tarin M., Phan, Tuan L., Zimmermann, Cosima, Zhou, Xiaofeng, Kaufer, Benedikt B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949924/
https://www.ncbi.nlm.nih.gov/pubmed/31801268
http://dx.doi.org/10.3390/v11121108
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author Denner, Joachim
Bigley, Tarin M.
Phan, Tuan L.
Zimmermann, Cosima
Zhou, Xiaofeng
Kaufer, Benedikt B.
author_facet Denner, Joachim
Bigley, Tarin M.
Phan, Tuan L.
Zimmermann, Cosima
Zhou, Xiaofeng
Kaufer, Benedikt B.
author_sort Denner, Joachim
collection PubMed
description Viruses of the genus Roseolovirus belong to the subfamily Betaherpesvirinae, family Herpesviridae. Roseoloviruses have been studied in humans, mice and pigs, but they are likely also present in other species. This is the first comparative analysis of roseoloviruses in humans and animals. The human roseoloviruses human herpesvirus 6A (HHV-6A), 6B (HHV-6B), and 7 (HHV-7) are relatively well characterized. In contrast, little is known about the murine roseolovirus (MRV), also known as murine thymic virus (MTV) or murine thymic lymphotrophic virus (MTLV), and the porcine roseolovirus (PRV), initially incorrectly named porcine cytomegalovirus (PCMV). Human roseoloviruses have gained attention because they can cause severe diseases including encephalitis in immunocompromised transplant and AIDS patients and febrile seizures in infants. They have been linked to a number of neurological diseases in the immunocompetent including multiple sclerosis (MS) and Alzheimer’s. However, to prove the causality in the latter disease associations is challenging due to the high prevalence of these viruses in the human population. PCMV/PRV has attracted attention because it may be transmitted and pose a risk in xenotransplantation, e.g., the transplantation of pig organs into humans. Most importantly, all roseoloviruses are immunosuppressive, the humoral and cellular immune responses against these viruses are not well studied and vaccines as well as effective antivirals are not available.
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spelling pubmed-69499242020-01-16 Comparative Analysis of Roseoloviruses in Humans, Pigs, Mice, and Other Species Denner, Joachim Bigley, Tarin M. Phan, Tuan L. Zimmermann, Cosima Zhou, Xiaofeng Kaufer, Benedikt B. Viruses Review Viruses of the genus Roseolovirus belong to the subfamily Betaherpesvirinae, family Herpesviridae. Roseoloviruses have been studied in humans, mice and pigs, but they are likely also present in other species. This is the first comparative analysis of roseoloviruses in humans and animals. The human roseoloviruses human herpesvirus 6A (HHV-6A), 6B (HHV-6B), and 7 (HHV-7) are relatively well characterized. In contrast, little is known about the murine roseolovirus (MRV), also known as murine thymic virus (MTV) or murine thymic lymphotrophic virus (MTLV), and the porcine roseolovirus (PRV), initially incorrectly named porcine cytomegalovirus (PCMV). Human roseoloviruses have gained attention because they can cause severe diseases including encephalitis in immunocompromised transplant and AIDS patients and febrile seizures in infants. They have been linked to a number of neurological diseases in the immunocompetent including multiple sclerosis (MS) and Alzheimer’s. However, to prove the causality in the latter disease associations is challenging due to the high prevalence of these viruses in the human population. PCMV/PRV has attracted attention because it may be transmitted and pose a risk in xenotransplantation, e.g., the transplantation of pig organs into humans. Most importantly, all roseoloviruses are immunosuppressive, the humoral and cellular immune responses against these viruses are not well studied and vaccines as well as effective antivirals are not available. MDPI 2019-11-30 /pmc/articles/PMC6949924/ /pubmed/31801268 http://dx.doi.org/10.3390/v11121108 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Denner, Joachim
Bigley, Tarin M.
Phan, Tuan L.
Zimmermann, Cosima
Zhou, Xiaofeng
Kaufer, Benedikt B.
Comparative Analysis of Roseoloviruses in Humans, Pigs, Mice, and Other Species
title Comparative Analysis of Roseoloviruses in Humans, Pigs, Mice, and Other Species
title_full Comparative Analysis of Roseoloviruses in Humans, Pigs, Mice, and Other Species
title_fullStr Comparative Analysis of Roseoloviruses in Humans, Pigs, Mice, and Other Species
title_full_unstemmed Comparative Analysis of Roseoloviruses in Humans, Pigs, Mice, and Other Species
title_short Comparative Analysis of Roseoloviruses in Humans, Pigs, Mice, and Other Species
title_sort comparative analysis of roseoloviruses in humans, pigs, mice, and other species
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949924/
https://www.ncbi.nlm.nih.gov/pubmed/31801268
http://dx.doi.org/10.3390/v11121108
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