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Bioactive Nitrogenous Secondary Metabolites from the Marine Sponge Genus Haliclona

Marine sponge genus Haliclona, one of the most prolific sources of natural products, contains over 600 species but only a small part of them had been classified and chemically investigated. On the basis of extensive literature search, this review firstly summarizes 112 nitrogenous secondary metaboli...

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Detalles Bibliográficos
Autores principales: Zhu, Jiaying, Liu, Yang, Liu, Zijun, Wang, Hao, Zhang, Huawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949942/
https://www.ncbi.nlm.nih.gov/pubmed/31816961
http://dx.doi.org/10.3390/md17120682
Descripción
Sumario:Marine sponge genus Haliclona, one of the most prolific sources of natural products, contains over 600 species but only a small part of them had been classified and chemically investigated. On the basis of extensive literature search, this review firstly summarizes 112 nitrogenous secondary metabolites from classified and unclassified Haliclona sponges as well as from their symbiotic microorganisms. Most of these substances have only been found in Haliclona sponges, and display diverse bioactive properties with potential applications in new drug discovery.