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Study of the Inhibitory Effects of Enteral Nutrition Formula on Indomethacin-Induced Gastric Lesions in Mice

We investigated the effects of enteral nutrition formula on non-steroidal anti-inflammatory drug (NSAID)-induced gastric lesions in mice. Male ICR mice aged 7–9 weeks old were fasted, then orally given either purified water, Mermed(®) One, or 2-fold diluted Terumeal(®) 2.0α as enteral nutrition (25...

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Autores principales: Yoshimi, Takeshi, Yamagishi, Yoshiaki, Kanegawa, Issei, Suda, Megumi, Saiki, Rei, Tanaka, Ken-ichiro, Goda, Hitomi, Kudo, Toshiyuki, Ito, Kiyomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949949/
https://www.ncbi.nlm.nih.gov/pubmed/31847337
http://dx.doi.org/10.3390/nu11123058
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author Yoshimi, Takeshi
Yamagishi, Yoshiaki
Kanegawa, Issei
Suda, Megumi
Saiki, Rei
Tanaka, Ken-ichiro
Goda, Hitomi
Kudo, Toshiyuki
Ito, Kiyomi
author_facet Yoshimi, Takeshi
Yamagishi, Yoshiaki
Kanegawa, Issei
Suda, Megumi
Saiki, Rei
Tanaka, Ken-ichiro
Goda, Hitomi
Kudo, Toshiyuki
Ito, Kiyomi
author_sort Yoshimi, Takeshi
collection PubMed
description We investigated the effects of enteral nutrition formula on non-steroidal anti-inflammatory drug (NSAID)-induced gastric lesions in mice. Male ICR mice aged 7–9 weeks old were fasted, then orally given either purified water, Mermed(®) One, or 2-fold diluted Terumeal(®) 2.0α as enteral nutrition (25 or 50 mL/kg each). Indomethacin (IND) was orally administered at 20 mg/kg after 30 min, and the stomach was removed 6 h later and fixed in formalin. The number and area of lesions in the stomachs of the mice given enteral nutrition showed a significant, dose-dependent decrease compared to the purified water-treated group, and no significant difference was seen between the two enteral nutrition-treated groups. Comparable time courses of plasma IND concentrations suggest that enteral nutrition does not inhibit gastrointestinal absorption of IND. Our findings indicate that administering enteral nutrition could inhibit the onset of NSAID-induced gastric ulcers.
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spelling pubmed-69499492020-01-16 Study of the Inhibitory Effects of Enteral Nutrition Formula on Indomethacin-Induced Gastric Lesions in Mice Yoshimi, Takeshi Yamagishi, Yoshiaki Kanegawa, Issei Suda, Megumi Saiki, Rei Tanaka, Ken-ichiro Goda, Hitomi Kudo, Toshiyuki Ito, Kiyomi Nutrients Article We investigated the effects of enteral nutrition formula on non-steroidal anti-inflammatory drug (NSAID)-induced gastric lesions in mice. Male ICR mice aged 7–9 weeks old were fasted, then orally given either purified water, Mermed(®) One, or 2-fold diluted Terumeal(®) 2.0α as enteral nutrition (25 or 50 mL/kg each). Indomethacin (IND) was orally administered at 20 mg/kg after 30 min, and the stomach was removed 6 h later and fixed in formalin. The number and area of lesions in the stomachs of the mice given enteral nutrition showed a significant, dose-dependent decrease compared to the purified water-treated group, and no significant difference was seen between the two enteral nutrition-treated groups. Comparable time courses of plasma IND concentrations suggest that enteral nutrition does not inhibit gastrointestinal absorption of IND. Our findings indicate that administering enteral nutrition could inhibit the onset of NSAID-induced gastric ulcers. MDPI 2019-12-14 /pmc/articles/PMC6949949/ /pubmed/31847337 http://dx.doi.org/10.3390/nu11123058 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoshimi, Takeshi
Yamagishi, Yoshiaki
Kanegawa, Issei
Suda, Megumi
Saiki, Rei
Tanaka, Ken-ichiro
Goda, Hitomi
Kudo, Toshiyuki
Ito, Kiyomi
Study of the Inhibitory Effects of Enteral Nutrition Formula on Indomethacin-Induced Gastric Lesions in Mice
title Study of the Inhibitory Effects of Enteral Nutrition Formula on Indomethacin-Induced Gastric Lesions in Mice
title_full Study of the Inhibitory Effects of Enteral Nutrition Formula on Indomethacin-Induced Gastric Lesions in Mice
title_fullStr Study of the Inhibitory Effects of Enteral Nutrition Formula on Indomethacin-Induced Gastric Lesions in Mice
title_full_unstemmed Study of the Inhibitory Effects of Enteral Nutrition Formula on Indomethacin-Induced Gastric Lesions in Mice
title_short Study of the Inhibitory Effects of Enteral Nutrition Formula on Indomethacin-Induced Gastric Lesions in Mice
title_sort study of the inhibitory effects of enteral nutrition formula on indomethacin-induced gastric lesions in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949949/
https://www.ncbi.nlm.nih.gov/pubmed/31847337
http://dx.doi.org/10.3390/nu11123058
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