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Vitamin D Concentration during Early Pregnancy and Adverse Outcomes among HIV-Negative Women in Dar-es-Salaam, Tanzania: A Case-Control Study

We examined the associations of plasma vitamin D concentration and adverse pregnancy outcomes among HIV-negative women in Dar-es-Salaam, Tanzania. We used an unmatched case-control study design, with 25-hydroxyvitamin D [25(OH)D] concentration assessed in the first trimester. Cases were individuals...

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Autores principales: Kalinjuma, Aneth V., Darling, Anne Marie, Sudfeld, Christopher R., Mugusi, Ferdinand, Wright, Julie, Abioye, Ajibola I., Aboud, Said, McDonald, Chloe, Hertzmark, Ellen, Kain, Kevin C., Fawzi, Wafaie W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949980/
https://www.ncbi.nlm.nih.gov/pubmed/31810155
http://dx.doi.org/10.3390/nu11122906
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author Kalinjuma, Aneth V.
Darling, Anne Marie
Sudfeld, Christopher R.
Mugusi, Ferdinand
Wright, Julie
Abioye, Ajibola I.
Aboud, Said
McDonald, Chloe
Hertzmark, Ellen
Kain, Kevin C.
Fawzi, Wafaie W.
author_facet Kalinjuma, Aneth V.
Darling, Anne Marie
Sudfeld, Christopher R.
Mugusi, Ferdinand
Wright, Julie
Abioye, Ajibola I.
Aboud, Said
McDonald, Chloe
Hertzmark, Ellen
Kain, Kevin C.
Fawzi, Wafaie W.
author_sort Kalinjuma, Aneth V.
collection PubMed
description We examined the associations of plasma vitamin D concentration and adverse pregnancy outcomes among HIV-negative women in Dar-es-Salaam, Tanzania. We used an unmatched case-control study design, with 25-hydroxyvitamin D [25(OH)D] concentration assessed in the first trimester. Cases were individuals with adverse pregnancy outcomes, including stillbirth, premature birth, or small for gestational age births (SGA). Unconditional logistic regression and weighted logistic regression models were used to describe the associations of 25(OH)D concentration with the composite of adverse pregnancy outcome and individual adverse pregnancy outcomes, respectively. We included 310 cases and 321 controls. In controls, 5(2%) were vitamin D deficient (25(OH)D < 20 ng/mL), and 17(5%) had insufficient 25(OH)D concentration (20.0–29.9 ng/mL). Women with 25(OH)D < 20 ng/mL had 1.82 times the odds of occurrence of the composite adverse pregnancy outcome (OR = 1.82, 95% CI: 0.56–5.93; p = 0.32), however we noted a non-linear association between 25(OH)D concentration and adverse pregnancy outcome (p = 0.02). We found a 3-fold increased odds of stillbirth in women with low 25(OH)D concentration (OR = 3.11, 95% CI: 1.18–8.23, p = 0.02). Vitamin D concentration in early pregnancy may be an important factor in determining the course of pregnancy. Further research is needed to investigate whether the association of maternal 25(OH)D concentration in early pregnancy and stillbirth is causal.
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spelling pubmed-69499802020-01-16 Vitamin D Concentration during Early Pregnancy and Adverse Outcomes among HIV-Negative Women in Dar-es-Salaam, Tanzania: A Case-Control Study Kalinjuma, Aneth V. Darling, Anne Marie Sudfeld, Christopher R. Mugusi, Ferdinand Wright, Julie Abioye, Ajibola I. Aboud, Said McDonald, Chloe Hertzmark, Ellen Kain, Kevin C. Fawzi, Wafaie W. Nutrients Article We examined the associations of plasma vitamin D concentration and adverse pregnancy outcomes among HIV-negative women in Dar-es-Salaam, Tanzania. We used an unmatched case-control study design, with 25-hydroxyvitamin D [25(OH)D] concentration assessed in the first trimester. Cases were individuals with adverse pregnancy outcomes, including stillbirth, premature birth, or small for gestational age births (SGA). Unconditional logistic regression and weighted logistic regression models were used to describe the associations of 25(OH)D concentration with the composite of adverse pregnancy outcome and individual adverse pregnancy outcomes, respectively. We included 310 cases and 321 controls. In controls, 5(2%) were vitamin D deficient (25(OH)D < 20 ng/mL), and 17(5%) had insufficient 25(OH)D concentration (20.0–29.9 ng/mL). Women with 25(OH)D < 20 ng/mL had 1.82 times the odds of occurrence of the composite adverse pregnancy outcome (OR = 1.82, 95% CI: 0.56–5.93; p = 0.32), however we noted a non-linear association between 25(OH)D concentration and adverse pregnancy outcome (p = 0.02). We found a 3-fold increased odds of stillbirth in women with low 25(OH)D concentration (OR = 3.11, 95% CI: 1.18–8.23, p = 0.02). Vitamin D concentration in early pregnancy may be an important factor in determining the course of pregnancy. Further research is needed to investigate whether the association of maternal 25(OH)D concentration in early pregnancy and stillbirth is causal. MDPI 2019-12-02 /pmc/articles/PMC6949980/ /pubmed/31810155 http://dx.doi.org/10.3390/nu11122906 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kalinjuma, Aneth V.
Darling, Anne Marie
Sudfeld, Christopher R.
Mugusi, Ferdinand
Wright, Julie
Abioye, Ajibola I.
Aboud, Said
McDonald, Chloe
Hertzmark, Ellen
Kain, Kevin C.
Fawzi, Wafaie W.
Vitamin D Concentration during Early Pregnancy and Adverse Outcomes among HIV-Negative Women in Dar-es-Salaam, Tanzania: A Case-Control Study
title Vitamin D Concentration during Early Pregnancy and Adverse Outcomes among HIV-Negative Women in Dar-es-Salaam, Tanzania: A Case-Control Study
title_full Vitamin D Concentration during Early Pregnancy and Adverse Outcomes among HIV-Negative Women in Dar-es-Salaam, Tanzania: A Case-Control Study
title_fullStr Vitamin D Concentration during Early Pregnancy and Adverse Outcomes among HIV-Negative Women in Dar-es-Salaam, Tanzania: A Case-Control Study
title_full_unstemmed Vitamin D Concentration during Early Pregnancy and Adverse Outcomes among HIV-Negative Women in Dar-es-Salaam, Tanzania: A Case-Control Study
title_short Vitamin D Concentration during Early Pregnancy and Adverse Outcomes among HIV-Negative Women in Dar-es-Salaam, Tanzania: A Case-Control Study
title_sort vitamin d concentration during early pregnancy and adverse outcomes among hiv-negative women in dar-es-salaam, tanzania: a case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949980/
https://www.ncbi.nlm.nih.gov/pubmed/31810155
http://dx.doi.org/10.3390/nu11122906
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