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Why Do Children in Slums Suffer from Anemia, Iron, Zinc, and Vitamin A Deficiency? Results from a Birth Cohort Study in Dhaka

Considering the high burden of micronutrient deficiencies in Bangladeshi children, this analysis aimed to identify the factors associated with micronutrient deficiencies and association of plasma micronutrient concentration trajectories from 7 to 24 months with the concentrations at 60 months of age...

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Autores principales: Mahfuz, Mustafa, Murray-Kolb, Laura E., Hasan, S. M. Tafsir, Das, Subhasish, Fahim, Shah Mohammad, Alam, Mohammed Ashraful, Caulfield, Laura, Ahmed, Tahmeed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949995/
https://www.ncbi.nlm.nih.gov/pubmed/31835764
http://dx.doi.org/10.3390/nu11123025
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author Mahfuz, Mustafa
Murray-Kolb, Laura E.
Hasan, S. M. Tafsir
Das, Subhasish
Fahim, Shah Mohammad
Alam, Mohammed Ashraful
Caulfield, Laura
Ahmed, Tahmeed
author_facet Mahfuz, Mustafa
Murray-Kolb, Laura E.
Hasan, S. M. Tafsir
Das, Subhasish
Fahim, Shah Mohammad
Alam, Mohammed Ashraful
Caulfield, Laura
Ahmed, Tahmeed
author_sort Mahfuz, Mustafa
collection PubMed
description Considering the high burden of micronutrient deficiencies in Bangladeshi children, this analysis aimed to identify the factors associated with micronutrient deficiencies and association of plasma micronutrient concentration trajectories from 7 to 24 months with the concentrations at 60 months of age. Plasma samples were collected at 7, 15, 24, and 60 months of age, and hemoglobin, ferritin, zinc, and retinol concentrations of 155, 153, 154, and 155 children were measured, respectively. A generalized estimating equation was used to identify the factors associated with micronutrient deficiencies, while latent class growth modeling identified the trajectories of plasma micronutrients from 7 to 24 months and its association with the concentrations of micronutrients at 60 months was examined using multiple linear regression modeling. Early (AOR = 2.21, p < 0.05) and late convalescence (AOR = 1.65, p < 0.05) stage of an infection, low ferritin (AOR = 3.04, p < 0.05), and low retinol (AOR = 2.07, p < 0.05) were associated with increased anemia prevalence. Wasting at enrollment was associated with zinc deficiency (AOR = 1.8, p < 0.05) and birth weight was associated with ferritin deficiency (AOR = 0.58, p < 0.05). Treatment of drinking water was found protective against vitamin A deficiency (AOR = 0.57, p < 0.05). Higher trajectories for ferritin and retinol during 7–24 months were positively associated with plasma ferritin (β = 13.72, p < 0.05) and plasma retinol (β = 3.99, p < 0.05) at 60 months.
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spelling pubmed-69499952020-01-16 Why Do Children in Slums Suffer from Anemia, Iron, Zinc, and Vitamin A Deficiency? Results from a Birth Cohort Study in Dhaka Mahfuz, Mustafa Murray-Kolb, Laura E. Hasan, S. M. Tafsir Das, Subhasish Fahim, Shah Mohammad Alam, Mohammed Ashraful Caulfield, Laura Ahmed, Tahmeed Nutrients Article Considering the high burden of micronutrient deficiencies in Bangladeshi children, this analysis aimed to identify the factors associated with micronutrient deficiencies and association of plasma micronutrient concentration trajectories from 7 to 24 months with the concentrations at 60 months of age. Plasma samples were collected at 7, 15, 24, and 60 months of age, and hemoglobin, ferritin, zinc, and retinol concentrations of 155, 153, 154, and 155 children were measured, respectively. A generalized estimating equation was used to identify the factors associated with micronutrient deficiencies, while latent class growth modeling identified the trajectories of plasma micronutrients from 7 to 24 months and its association with the concentrations of micronutrients at 60 months was examined using multiple linear regression modeling. Early (AOR = 2.21, p < 0.05) and late convalescence (AOR = 1.65, p < 0.05) stage of an infection, low ferritin (AOR = 3.04, p < 0.05), and low retinol (AOR = 2.07, p < 0.05) were associated with increased anemia prevalence. Wasting at enrollment was associated with zinc deficiency (AOR = 1.8, p < 0.05) and birth weight was associated with ferritin deficiency (AOR = 0.58, p < 0.05). Treatment of drinking water was found protective against vitamin A deficiency (AOR = 0.57, p < 0.05). Higher trajectories for ferritin and retinol during 7–24 months were positively associated with plasma ferritin (β = 13.72, p < 0.05) and plasma retinol (β = 3.99, p < 0.05) at 60 months. MDPI 2019-12-11 /pmc/articles/PMC6949995/ /pubmed/31835764 http://dx.doi.org/10.3390/nu11123025 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mahfuz, Mustafa
Murray-Kolb, Laura E.
Hasan, S. M. Tafsir
Das, Subhasish
Fahim, Shah Mohammad
Alam, Mohammed Ashraful
Caulfield, Laura
Ahmed, Tahmeed
Why Do Children in Slums Suffer from Anemia, Iron, Zinc, and Vitamin A Deficiency? Results from a Birth Cohort Study in Dhaka
title Why Do Children in Slums Suffer from Anemia, Iron, Zinc, and Vitamin A Deficiency? Results from a Birth Cohort Study in Dhaka
title_full Why Do Children in Slums Suffer from Anemia, Iron, Zinc, and Vitamin A Deficiency? Results from a Birth Cohort Study in Dhaka
title_fullStr Why Do Children in Slums Suffer from Anemia, Iron, Zinc, and Vitamin A Deficiency? Results from a Birth Cohort Study in Dhaka
title_full_unstemmed Why Do Children in Slums Suffer from Anemia, Iron, Zinc, and Vitamin A Deficiency? Results from a Birth Cohort Study in Dhaka
title_short Why Do Children in Slums Suffer from Anemia, Iron, Zinc, and Vitamin A Deficiency? Results from a Birth Cohort Study in Dhaka
title_sort why do children in slums suffer from anemia, iron, zinc, and vitamin a deficiency? results from a birth cohort study in dhaka
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949995/
https://www.ncbi.nlm.nih.gov/pubmed/31835764
http://dx.doi.org/10.3390/nu11123025
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