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The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species
Cardiovascular diseases remain the leading global cause of mortality indicating the need to identify all possible factors reducing primary and secondary risk. This study screened the in vitro antiplatelet and anticoagulant activities of hot water extracts of eight edible mushroom species (Agaricus b...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950045/ https://www.ncbi.nlm.nih.gov/pubmed/31842490 http://dx.doi.org/10.3390/nu11123040 |
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author | Poniedziałek, Barbara Siwulski, Marek Wiater, Adrian Komaniecka, Iwona Komosa, Anna Gąsecka, Monika Magdziak, Zuzanna Mleczek, Mirosław Niedzielski, Przemysław Proch, Jędrzej Ropacka-Lesiak, Mariola Lesiak, Maciej Henao, Eliana Rzymski, Piotr |
author_facet | Poniedziałek, Barbara Siwulski, Marek Wiater, Adrian Komaniecka, Iwona Komosa, Anna Gąsecka, Monika Magdziak, Zuzanna Mleczek, Mirosław Niedzielski, Przemysław Proch, Jędrzej Ropacka-Lesiak, Mariola Lesiak, Maciej Henao, Eliana Rzymski, Piotr |
author_sort | Poniedziałek, Barbara |
collection | PubMed |
description | Cardiovascular diseases remain the leading global cause of mortality indicating the need to identify all possible factors reducing primary and secondary risk. This study screened the in vitro antiplatelet and anticoagulant activities of hot water extracts of eight edible mushroom species (Agaricus bisporus, Auricularia auricularia-judae, Coprinus comatus, Ganoderma lucidum, Hericium erinaceus, Lentinula edodes, Pleurotus eryngii, and Pleurotus ostreatus) increasingly cultivated for human consumption, and compared them to those evoked by acetylsalicylic acid (ASA). The antioxidant capacity and concentration of polysaccharides, phenolic compounds, organic acids, ergosterol, macro elements, and trace elements were also characterized. The most promising antiplatelet effect was exhibited by A. auricularia-judae and P. eryngii extracts as demonstrated by the highest rate of inhibition of adenosine-5′-diphosphate (ADP)-induced and arachidonic acid (AA)-induced aggregation. The response to both extracts exceeded the one evoked by 140 µmol/L of ASA in the ADP test and was comparable to it in the case of the AA test. Such a dual effect was also observed for G. lucidum extract, even though it was proven to be cytotoxic in platelets and leukocytes. The extract of P. ostreatus revealed an additive effect on AA-induced platelet aggregation. None of the mushroom extracts altered the monitored coagulation parameters (prothrombin time, prothrombin ratio, and International Normalized Ratio). The effect of mushroom extracts on platelet function was positively related to their antioxidative properties and concentration of polysaccharides and ergosterol, and inversely related to zinc concentration. The study suggests that selected mushrooms may exert favorable antiplatelet effects, highlighting the need for further experimental and clinical research in this regard. |
format | Online Article Text |
id | pubmed-6950045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69500452020-01-13 The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species Poniedziałek, Barbara Siwulski, Marek Wiater, Adrian Komaniecka, Iwona Komosa, Anna Gąsecka, Monika Magdziak, Zuzanna Mleczek, Mirosław Niedzielski, Przemysław Proch, Jędrzej Ropacka-Lesiak, Mariola Lesiak, Maciej Henao, Eliana Rzymski, Piotr Nutrients Article Cardiovascular diseases remain the leading global cause of mortality indicating the need to identify all possible factors reducing primary and secondary risk. This study screened the in vitro antiplatelet and anticoagulant activities of hot water extracts of eight edible mushroom species (Agaricus bisporus, Auricularia auricularia-judae, Coprinus comatus, Ganoderma lucidum, Hericium erinaceus, Lentinula edodes, Pleurotus eryngii, and Pleurotus ostreatus) increasingly cultivated for human consumption, and compared them to those evoked by acetylsalicylic acid (ASA). The antioxidant capacity and concentration of polysaccharides, phenolic compounds, organic acids, ergosterol, macro elements, and trace elements were also characterized. The most promising antiplatelet effect was exhibited by A. auricularia-judae and P. eryngii extracts as demonstrated by the highest rate of inhibition of adenosine-5′-diphosphate (ADP)-induced and arachidonic acid (AA)-induced aggregation. The response to both extracts exceeded the one evoked by 140 µmol/L of ASA in the ADP test and was comparable to it in the case of the AA test. Such a dual effect was also observed for G. lucidum extract, even though it was proven to be cytotoxic in platelets and leukocytes. The extract of P. ostreatus revealed an additive effect on AA-induced platelet aggregation. None of the mushroom extracts altered the monitored coagulation parameters (prothrombin time, prothrombin ratio, and International Normalized Ratio). The effect of mushroom extracts on platelet function was positively related to their antioxidative properties and concentration of polysaccharides and ergosterol, and inversely related to zinc concentration. The study suggests that selected mushrooms may exert favorable antiplatelet effects, highlighting the need for further experimental and clinical research in this regard. MDPI 2019-12-12 /pmc/articles/PMC6950045/ /pubmed/31842490 http://dx.doi.org/10.3390/nu11123040 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Poniedziałek, Barbara Siwulski, Marek Wiater, Adrian Komaniecka, Iwona Komosa, Anna Gąsecka, Monika Magdziak, Zuzanna Mleczek, Mirosław Niedzielski, Przemysław Proch, Jędrzej Ropacka-Lesiak, Mariola Lesiak, Maciej Henao, Eliana Rzymski, Piotr The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species |
title | The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species |
title_full | The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species |
title_fullStr | The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species |
title_full_unstemmed | The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species |
title_short | The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species |
title_sort | effect of mushroom extracts on human platelet and blood coagulation: in vitro screening of eight edible species |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950045/ https://www.ncbi.nlm.nih.gov/pubmed/31842490 http://dx.doi.org/10.3390/nu11123040 |
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