Cargando…

Dietary Interventions for Gout and Effect on Cardiovascular Risk Factors: A Systematic Review

Gout is one of the most prevalent inflammatory rheumatic disease. It is preceded by hyperuricemia and associated with an increased risk for cardiovascular disease, both related to unhealthy diets. The objective of this systematic review is to better define the most appropriate diet addressing both d...

Descripción completa

Detalles Bibliográficos
Autores principales: Vedder, Daisy, Walrabenstein, Wendy, Heslinga, Maaike, de Vries, Ralph, Nurmohamed, Michael, van Schaardenburg, Dirkjan, Gerritsen, Martijn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950134/
https://www.ncbi.nlm.nih.gov/pubmed/31817107
http://dx.doi.org/10.3390/nu11122955
_version_ 1783486000567156736
author Vedder, Daisy
Walrabenstein, Wendy
Heslinga, Maaike
de Vries, Ralph
Nurmohamed, Michael
van Schaardenburg, Dirkjan
Gerritsen, Martijn
author_facet Vedder, Daisy
Walrabenstein, Wendy
Heslinga, Maaike
de Vries, Ralph
Nurmohamed, Michael
van Schaardenburg, Dirkjan
Gerritsen, Martijn
author_sort Vedder, Daisy
collection PubMed
description Gout is one of the most prevalent inflammatory rheumatic disease. It is preceded by hyperuricemia and associated with an increased risk for cardiovascular disease, both related to unhealthy diets. The objective of this systematic review is to better define the most appropriate diet addressing both disease activity and traditional cardiovascular risk factors in hyperuricemic patients. We included clinical trials with patients diagnosed with hyperuricemia or gout, investigating the effect of dietary interventions on serum uric acid (SUA) levels, gout flares and—if available—cardiovascular risk factors. Eighteen articles were included, which were too heterogeneous to perform a meta-analysis. Overall, the risk of bias of the studies was moderate to high. We distinguished four groups of dietary interventions: Calorie restriction and fasting, purine-low diets, Mediterranean-style diets, and supplements. Overall, fasting resulted in an increase of SUA, whilst small (SUA change +0.3 to −2.9 mg/dL) but significant effects were found after low-calorie, purine-low, and Mediterranean-style diets. Studies investigating the effect on cardiovascular risk factors were limited and inconclusive. Since Mediterranean-style diets/DASH (Dietary Approach to Stop Hypertension) have shown to be effective for the reduction of cardiovascular risk factors in other at-risk populations, we recommend further investigation of such diets for the treatment of gout.
format Online
Article
Text
id pubmed-6950134
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69501342020-01-13 Dietary Interventions for Gout and Effect on Cardiovascular Risk Factors: A Systematic Review Vedder, Daisy Walrabenstein, Wendy Heslinga, Maaike de Vries, Ralph Nurmohamed, Michael van Schaardenburg, Dirkjan Gerritsen, Martijn Nutrients Review Gout is one of the most prevalent inflammatory rheumatic disease. It is preceded by hyperuricemia and associated with an increased risk for cardiovascular disease, both related to unhealthy diets. The objective of this systematic review is to better define the most appropriate diet addressing both disease activity and traditional cardiovascular risk factors in hyperuricemic patients. We included clinical trials with patients diagnosed with hyperuricemia or gout, investigating the effect of dietary interventions on serum uric acid (SUA) levels, gout flares and—if available—cardiovascular risk factors. Eighteen articles were included, which were too heterogeneous to perform a meta-analysis. Overall, the risk of bias of the studies was moderate to high. We distinguished four groups of dietary interventions: Calorie restriction and fasting, purine-low diets, Mediterranean-style diets, and supplements. Overall, fasting resulted in an increase of SUA, whilst small (SUA change +0.3 to −2.9 mg/dL) but significant effects were found after low-calorie, purine-low, and Mediterranean-style diets. Studies investigating the effect on cardiovascular risk factors were limited and inconclusive. Since Mediterranean-style diets/DASH (Dietary Approach to Stop Hypertension) have shown to be effective for the reduction of cardiovascular risk factors in other at-risk populations, we recommend further investigation of such diets for the treatment of gout. MDPI 2019-12-04 /pmc/articles/PMC6950134/ /pubmed/31817107 http://dx.doi.org/10.3390/nu11122955 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vedder, Daisy
Walrabenstein, Wendy
Heslinga, Maaike
de Vries, Ralph
Nurmohamed, Michael
van Schaardenburg, Dirkjan
Gerritsen, Martijn
Dietary Interventions for Gout and Effect on Cardiovascular Risk Factors: A Systematic Review
title Dietary Interventions for Gout and Effect on Cardiovascular Risk Factors: A Systematic Review
title_full Dietary Interventions for Gout and Effect on Cardiovascular Risk Factors: A Systematic Review
title_fullStr Dietary Interventions for Gout and Effect on Cardiovascular Risk Factors: A Systematic Review
title_full_unstemmed Dietary Interventions for Gout and Effect on Cardiovascular Risk Factors: A Systematic Review
title_short Dietary Interventions for Gout and Effect on Cardiovascular Risk Factors: A Systematic Review
title_sort dietary interventions for gout and effect on cardiovascular risk factors: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950134/
https://www.ncbi.nlm.nih.gov/pubmed/31817107
http://dx.doi.org/10.3390/nu11122955
work_keys_str_mv AT vedderdaisy dietaryinterventionsforgoutandeffectoncardiovascularriskfactorsasystematicreview
AT walrabensteinwendy dietaryinterventionsforgoutandeffectoncardiovascularriskfactorsasystematicreview
AT heslingamaaike dietaryinterventionsforgoutandeffectoncardiovascularriskfactorsasystematicreview
AT devriesralph dietaryinterventionsforgoutandeffectoncardiovascularriskfactorsasystematicreview
AT nurmohamedmichael dietaryinterventionsforgoutandeffectoncardiovascularriskfactorsasystematicreview
AT vanschaardenburgdirkjan dietaryinterventionsforgoutandeffectoncardiovascularriskfactorsasystematicreview
AT gerritsenmartijn dietaryinterventionsforgoutandeffectoncardiovascularriskfactorsasystematicreview