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Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus Penicillium sp. JY246

Four new xanthene derivatives, penicixanthenes A–D (1–4), and one known compound 5 were isolated from a marine mangrove endophytic fungus Penicillium sp. JY246 that was obtained from the stem of Ceriops tagal. Their structures were determined by detailed NMR, MS spectroscopic data, modified Mosher’s...

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Autores principales: Bai, Meng, Zheng, Cai-Juan, Nong, Xu-Hua, Zhou, Xue-Ming, Luo, You-Ping, Chen, Guang-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950184/
https://www.ncbi.nlm.nih.gov/pubmed/31756930
http://dx.doi.org/10.3390/md17120649
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author Bai, Meng
Zheng, Cai-Juan
Nong, Xu-Hua
Zhou, Xue-Ming
Luo, You-Ping
Chen, Guang-Ying
author_facet Bai, Meng
Zheng, Cai-Juan
Nong, Xu-Hua
Zhou, Xue-Ming
Luo, You-Ping
Chen, Guang-Ying
author_sort Bai, Meng
collection PubMed
description Four new xanthene derivatives, penicixanthenes A–D (1–4), and one known compound 5 were isolated from a marine mangrove endophytic fungus Penicillium sp. JY246 that was obtained from the stem of Ceriops tagal. Their structures were determined by detailed NMR, MS spectroscopic data, modified Mosher’s method, and calculated electronic circular dichroism data. All of the isolated compounds were examined for insecticidal activity. Compounds 2 and 3 showed growth inhibition activity against newly hatched larvae of Helicoverpa armigera Hubner with the IC(50) values 100 and 200 μg/mL, respectively, and compounds 1, 3, and 4 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with LC(50) values of 38.5 (±1.16), 11.6 (±0.58), and 20.5 (±1) μg/mL, respectively. The four xanthene derivatives have the potential to be developed as new biopesticides.
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spelling pubmed-69501842020-01-16 Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus Penicillium sp. JY246 Bai, Meng Zheng, Cai-Juan Nong, Xu-Hua Zhou, Xue-Ming Luo, You-Ping Chen, Guang-Ying Mar Drugs Article Four new xanthene derivatives, penicixanthenes A–D (1–4), and one known compound 5 were isolated from a marine mangrove endophytic fungus Penicillium sp. JY246 that was obtained from the stem of Ceriops tagal. Their structures were determined by detailed NMR, MS spectroscopic data, modified Mosher’s method, and calculated electronic circular dichroism data. All of the isolated compounds were examined for insecticidal activity. Compounds 2 and 3 showed growth inhibition activity against newly hatched larvae of Helicoverpa armigera Hubner with the IC(50) values 100 and 200 μg/mL, respectively, and compounds 1, 3, and 4 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with LC(50) values of 38.5 (±1.16), 11.6 (±0.58), and 20.5 (±1) μg/mL, respectively. The four xanthene derivatives have the potential to be developed as new biopesticides. MDPI 2019-11-20 /pmc/articles/PMC6950184/ /pubmed/31756930 http://dx.doi.org/10.3390/md17120649 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bai, Meng
Zheng, Cai-Juan
Nong, Xu-Hua
Zhou, Xue-Ming
Luo, You-Ping
Chen, Guang-Ying
Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus Penicillium sp. JY246
title Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus Penicillium sp. JY246
title_full Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus Penicillium sp. JY246
title_fullStr Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus Penicillium sp. JY246
title_full_unstemmed Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus Penicillium sp. JY246
title_short Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus Penicillium sp. JY246
title_sort four new insecticidal xanthene derivatives from the mangrove-derived fungus penicillium sp. jy246
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950184/
https://www.ncbi.nlm.nih.gov/pubmed/31756930
http://dx.doi.org/10.3390/md17120649
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