Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents

[Image: see text] Starting from a hit series from a GNF compound library collection and based on a cell-based proliferation assay of Plasmodium falciparum, a novel imidazolopiperazine scaffold was optimized. SAR for this series of compounds is discussed, focusing on optimization of cellular potency...

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Detalles Bibliográficos
Autores principales: Wu, Tao, Nagle, Advait, Kuhen, Kelli, Gagaring, Kerstin, Borboa, Rachel, Francek, Caroline, Chen, Zhong, Plouffe, David, Goh, Anne, Lakshminarayana, Suresh B., Wu, Jeanette, Ang, Hui Qing, Zeng, Peiting, Kang, Min Low, Tan, William, Tan, Maria, Ye, Nicole, Lin, Xuena, Caldwell, Christopher, Ek, Jared, Skolnik, Suzanne, Liu, Fenghua, Wang, Jianling, Chang, Jonathan, Li, Chun, Hollenbeck, Thomas, Tuntland, Tove, Isbell, John, Fischli, Christoph, Brun, Reto, Rottmann, Matthias, Dartois, Veronique, Keller, Thomas, Diagana, Thierry, Winzeler, Elizabeth, Glynne, Richard, Tully, David C., Chatterjee, Arnab K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950218/
https://www.ncbi.nlm.nih.gov/pubmed/21644570
http://dx.doi.org/10.1021/jm2003359

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