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Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood
Obesity and related disorders, which are increasing in adults worldwide, are closely linked to childhood diet and are associated with chronic inflammation. Rice endosperm protein (REP) intake during adulthood has been reported to improve lipid metabolism and suppress the progression of diabetic kidn...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950226/ https://www.ncbi.nlm.nih.gov/pubmed/31810329 http://dx.doi.org/10.3390/nu11122919 |
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author | Higuchi, Yuki Hosojima, Michihiro Kabasawa, Hideyuki Kuwahara, Shoji Goto, Sawako Toba, Koji Kaseda, Ryohei Tanaka, Takahiro Kitamura, Nobutaka Takihara, Hayato Okuda, Shujiro Taniguchi, Masayuki Arao, Hitoshi Narita, Ichiei Saito, Akihiko |
author_facet | Higuchi, Yuki Hosojima, Michihiro Kabasawa, Hideyuki Kuwahara, Shoji Goto, Sawako Toba, Koji Kaseda, Ryohei Tanaka, Takahiro Kitamura, Nobutaka Takihara, Hayato Okuda, Shujiro Taniguchi, Masayuki Arao, Hitoshi Narita, Ichiei Saito, Akihiko |
author_sort | Higuchi, Yuki |
collection | PubMed |
description | Obesity and related disorders, which are increasing in adults worldwide, are closely linked to childhood diet and are associated with chronic inflammation. Rice endosperm protein (REP) intake during adulthood has been reported to improve lipid metabolism and suppress the progression of diabetic kidney disease in animal models. However, the effects of REP intake during childhood on adulthood health are unclear. Therefore, we used a mouse model to experimentally investigate the preconditioning effects of REP intake during childhood on the development of obesity and related disorders in adulthood. Male C57BL/6J mice were pair-fed a normal-fat diet containing casein or REP during the juvenile period and then a high-fat diet (HFD) containing casein or REP during adulthood. Mice fed REP during the juvenile period showed better body weight, blood pressure, serum lipid profiles, lipopolysaccharide (LPS)-binding protein levels, and glucose tolerance in adulthood than those fed casein during the juvenile period. HFD-induced renal tubulo-glomerular alterations and hepatic microvesicular steatosis were less evident in REP-fed mice than in casein-fed ones. REP intake during the juvenile period improved HFD-induced dysbiosis (i.e., Escherichia genus proliferation and reduced gut microbiota diversity), thereby suppressing endotoxin-related chronic inflammation. Indeed, REP-derived peptides showed antibacterial activity against Escherichia coli, a major producer of LPS. In conclusion, REP supplementation during the juvenile period may regulate the gut microbiota and thus suppress the development of obesity and related disorders in adulthood in mice. |
format | Online Article Text |
id | pubmed-6950226 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69502262020-01-16 Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood Higuchi, Yuki Hosojima, Michihiro Kabasawa, Hideyuki Kuwahara, Shoji Goto, Sawako Toba, Koji Kaseda, Ryohei Tanaka, Takahiro Kitamura, Nobutaka Takihara, Hayato Okuda, Shujiro Taniguchi, Masayuki Arao, Hitoshi Narita, Ichiei Saito, Akihiko Nutrients Article Obesity and related disorders, which are increasing in adults worldwide, are closely linked to childhood diet and are associated with chronic inflammation. Rice endosperm protein (REP) intake during adulthood has been reported to improve lipid metabolism and suppress the progression of diabetic kidney disease in animal models. However, the effects of REP intake during childhood on adulthood health are unclear. Therefore, we used a mouse model to experimentally investigate the preconditioning effects of REP intake during childhood on the development of obesity and related disorders in adulthood. Male C57BL/6J mice were pair-fed a normal-fat diet containing casein or REP during the juvenile period and then a high-fat diet (HFD) containing casein or REP during adulthood. Mice fed REP during the juvenile period showed better body weight, blood pressure, serum lipid profiles, lipopolysaccharide (LPS)-binding protein levels, and glucose tolerance in adulthood than those fed casein during the juvenile period. HFD-induced renal tubulo-glomerular alterations and hepatic microvesicular steatosis were less evident in REP-fed mice than in casein-fed ones. REP intake during the juvenile period improved HFD-induced dysbiosis (i.e., Escherichia genus proliferation and reduced gut microbiota diversity), thereby suppressing endotoxin-related chronic inflammation. Indeed, REP-derived peptides showed antibacterial activity against Escherichia coli, a major producer of LPS. In conclusion, REP supplementation during the juvenile period may regulate the gut microbiota and thus suppress the development of obesity and related disorders in adulthood in mice. MDPI 2019-12-02 /pmc/articles/PMC6950226/ /pubmed/31810329 http://dx.doi.org/10.3390/nu11122919 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Higuchi, Yuki Hosojima, Michihiro Kabasawa, Hideyuki Kuwahara, Shoji Goto, Sawako Toba, Koji Kaseda, Ryohei Tanaka, Takahiro Kitamura, Nobutaka Takihara, Hayato Okuda, Shujiro Taniguchi, Masayuki Arao, Hitoshi Narita, Ichiei Saito, Akihiko Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood |
title | Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood |
title_full | Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood |
title_fullStr | Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood |
title_full_unstemmed | Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood |
title_short | Rice Endosperm Protein Administration to Juvenile Mice Regulates Gut Microbiota and Suppresses the Development of High-Fat Diet-Induced Obesity and Related Disorders in Adulthood |
title_sort | rice endosperm protein administration to juvenile mice regulates gut microbiota and suppresses the development of high-fat diet-induced obesity and related disorders in adulthood |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950226/ https://www.ncbi.nlm.nih.gov/pubmed/31810329 http://dx.doi.org/10.3390/nu11122919 |
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