Cargando…

Evaluation of Dietary Approaches for the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review

Lifestyle interventions, namely optimizing nutrition and increasing physical activity, remain the cornerstone of therapy for non-alcoholic fatty liver disease (NAFLD), as this can lead to the significant improvement or resolution of disease. The optimal nutritional approach to treat NAFLD remains un...

Descripción completa

Detalles Bibliográficos
Autores principales: Saeed, Naba, Nadeau, Brian, Shannon, Carol, Tincopa, Monica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950283/
https://www.ncbi.nlm.nih.gov/pubmed/31888132
http://dx.doi.org/10.3390/nu11123064
_version_ 1783486035559186432
author Saeed, Naba
Nadeau, Brian
Shannon, Carol
Tincopa, Monica
author_facet Saeed, Naba
Nadeau, Brian
Shannon, Carol
Tincopa, Monica
author_sort Saeed, Naba
collection PubMed
description Lifestyle interventions, namely optimizing nutrition and increasing physical activity, remain the cornerstone of therapy for non-alcoholic fatty liver disease (NAFLD), as this can lead to the significant improvement or resolution of disease. The optimal nutritional approach to treat NAFLD remains unclear. The aim of this systematic review is to evaluate the effectiveness of different nutritional patterns on hepatic, metabolic, and weight-loss endpoints. MEDLINE via PubMed, Embase, Scopus, and Google Scholar were searched. Randomized trials of dietary interventions alone for adults with NAFLD were selected. Two authors independently reviewed articles, to select eligible studies, and performed data abstraction. Six studies, representing 317 patients, were included. The participants had a median age of 46, mean body mass index (BMI) 31.5 and were 64.3% male. The mean study duration was 16.33 ± 8.62 weeks. Reduction in hepatic steatosis (HS) was statistically significant in 3/5 Mediterranean Diet (MD), one low-carbohydrate, one intermittent fasting (IF) and 1/2 low fat (LF) diet interventions. A total of 3/5 studies using MD, 1/2 LF interventions, and the one IF intervention demonstrated significant reductions in weight. In conclusion, there appears to be most data in support of MD-based interventions, though further randomized trials are needed to assess comparative effectiveness for NAFLD.
format Online
Article
Text
id pubmed-6950283
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69502832020-01-16 Evaluation of Dietary Approaches for the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review Saeed, Naba Nadeau, Brian Shannon, Carol Tincopa, Monica Nutrients Review Lifestyle interventions, namely optimizing nutrition and increasing physical activity, remain the cornerstone of therapy for non-alcoholic fatty liver disease (NAFLD), as this can lead to the significant improvement or resolution of disease. The optimal nutritional approach to treat NAFLD remains unclear. The aim of this systematic review is to evaluate the effectiveness of different nutritional patterns on hepatic, metabolic, and weight-loss endpoints. MEDLINE via PubMed, Embase, Scopus, and Google Scholar were searched. Randomized trials of dietary interventions alone for adults with NAFLD were selected. Two authors independently reviewed articles, to select eligible studies, and performed data abstraction. Six studies, representing 317 patients, were included. The participants had a median age of 46, mean body mass index (BMI) 31.5 and were 64.3% male. The mean study duration was 16.33 ± 8.62 weeks. Reduction in hepatic steatosis (HS) was statistically significant in 3/5 Mediterranean Diet (MD), one low-carbohydrate, one intermittent fasting (IF) and 1/2 low fat (LF) diet interventions. A total of 3/5 studies using MD, 1/2 LF interventions, and the one IF intervention demonstrated significant reductions in weight. In conclusion, there appears to be most data in support of MD-based interventions, though further randomized trials are needed to assess comparative effectiveness for NAFLD. MDPI 2019-12-16 /pmc/articles/PMC6950283/ /pubmed/31888132 http://dx.doi.org/10.3390/nu11123064 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Saeed, Naba
Nadeau, Brian
Shannon, Carol
Tincopa, Monica
Evaluation of Dietary Approaches for the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review
title Evaluation of Dietary Approaches for the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review
title_full Evaluation of Dietary Approaches for the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review
title_fullStr Evaluation of Dietary Approaches for the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review
title_full_unstemmed Evaluation of Dietary Approaches for the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review
title_short Evaluation of Dietary Approaches for the Treatment of Non-Alcoholic Fatty Liver Disease: A Systematic Review
title_sort evaluation of dietary approaches for the treatment of non-alcoholic fatty liver disease: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950283/
https://www.ncbi.nlm.nih.gov/pubmed/31888132
http://dx.doi.org/10.3390/nu11123064
work_keys_str_mv AT saeednaba evaluationofdietaryapproachesforthetreatmentofnonalcoholicfattyliverdiseaseasystematicreview
AT nadeaubrian evaluationofdietaryapproachesforthetreatmentofnonalcoholicfattyliverdiseaseasystematicreview
AT shannoncarol evaluationofdietaryapproachesforthetreatmentofnonalcoholicfattyliverdiseaseasystematicreview
AT tincopamonica evaluationofdietaryapproachesforthetreatmentofnonalcoholicfattyliverdiseaseasystematicreview