Cargando…

Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts

Marine ascidians are becoming important drug sources that provide abundant secondary metabolites with novel structures and high bioactivities. As one of the most chemically prolific marine animals, more than 1200 inspirational natural products, such as alkaloids, peptides, and polyketides, with intr...

Descripción completa

Detalles Bibliográficos
Autores principales: Dou, Xiaoju, Dong, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950356/
https://www.ncbi.nlm.nih.gov/pubmed/31795141
http://dx.doi.org/10.3390/md17120670
_version_ 1783486053017976832
author Dou, Xiaoju
Dong, Bo
author_facet Dou, Xiaoju
Dong, Bo
author_sort Dou, Xiaoju
collection PubMed
description Marine ascidians are becoming important drug sources that provide abundant secondary metabolites with novel structures and high bioactivities. As one of the most chemically prolific marine animals, more than 1200 inspirational natural products, such as alkaloids, peptides, and polyketides, with intricate and novel chemical structures have been identified from ascidians. Some of them have been successfully developed as lead compounds or highly efficient drugs. Although numerous compounds that exist in ascidians have been structurally and functionally identified, their origins are not clear. Interestingly, growing evidence has shown that these natural products not only come from ascidians, but they also originate from symbiotic microbes. This review classifies the identified natural products from ascidians and the associated symbionts. Then, we discuss the diversity of ascidian symbiotic microbe communities, which synthesize diverse natural products that are beneficial for the hosts. Identification of the complex interactions between the symbiont and the host is a useful approach to discovering ways that direct the biosynthesis of novel bioactive compounds with pharmaceutical potentials.
format Online
Article
Text
id pubmed-6950356
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69503562020-01-16 Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts Dou, Xiaoju Dong, Bo Mar Drugs Review Marine ascidians are becoming important drug sources that provide abundant secondary metabolites with novel structures and high bioactivities. As one of the most chemically prolific marine animals, more than 1200 inspirational natural products, such as alkaloids, peptides, and polyketides, with intricate and novel chemical structures have been identified from ascidians. Some of them have been successfully developed as lead compounds or highly efficient drugs. Although numerous compounds that exist in ascidians have been structurally and functionally identified, their origins are not clear. Interestingly, growing evidence has shown that these natural products not only come from ascidians, but they also originate from symbiotic microbes. This review classifies the identified natural products from ascidians and the associated symbionts. Then, we discuss the diversity of ascidian symbiotic microbe communities, which synthesize diverse natural products that are beneficial for the hosts. Identification of the complex interactions between the symbiont and the host is a useful approach to discovering ways that direct the biosynthesis of novel bioactive compounds with pharmaceutical potentials. MDPI 2019-11-28 /pmc/articles/PMC6950356/ /pubmed/31795141 http://dx.doi.org/10.3390/md17120670 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dou, Xiaoju
Dong, Bo
Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts
title Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts
title_full Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts
title_fullStr Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts
title_full_unstemmed Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts
title_short Origins and Bioactivities of Natural Compounds Derived from Marine Ascidians and Their Symbionts
title_sort origins and bioactivities of natural compounds derived from marine ascidians and their symbionts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950356/
https://www.ncbi.nlm.nih.gov/pubmed/31795141
http://dx.doi.org/10.3390/md17120670
work_keys_str_mv AT douxiaoju originsandbioactivitiesofnaturalcompoundsderivedfrommarineascidiansandtheirsymbionts
AT dongbo originsandbioactivitiesofnaturalcompoundsderivedfrommarineascidiansandtheirsymbionts