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Fragmented Dosing of β-alanine Induces A Body Weight-Independent Pharmacokinetic Response

Personalised dosing of performance-enhancing food supplements is a hot topic. β-alanine is currently dosed using a fixed dose; however, evidence suggests that this might favour light compared to heavy subjects. A weight-relative dose seems to reverse this problem. In the present study, a novel dosin...

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Autores principales: Stautemas, Jan, Van de Loock, Alexia, Van der Stede, Thibaux, Pringels, Lauren, Derave, Wim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950400/
https://www.ncbi.nlm.nih.gov/pubmed/31771148
http://dx.doi.org/10.3390/nu11122869
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author Stautemas, Jan
Van de Loock, Alexia
Van der Stede, Thibaux
Pringels, Lauren
Derave, Wim
author_facet Stautemas, Jan
Van de Loock, Alexia
Van der Stede, Thibaux
Pringels, Lauren
Derave, Wim
author_sort Stautemas, Jan
collection PubMed
description Personalised dosing of performance-enhancing food supplements is a hot topic. β-alanine is currently dosed using a fixed dose; however, evidence suggests that this might favour light compared to heavy subjects. A weight-relative dose seems to reverse this problem. In the present study, a novel dosing strategy was tested. A fragmented dose, composed of a fixed fragment of 800 mg and a weight-relative fragment of 10 mg/kg body weight, was compared to a fixed dose of 1600 mg and a weight-relative dose of 20 mg/kg body weight in a cohort of 20 subjects with a body weight ranging 48–139 kg (79.9 ± 24.4 kg). The results show that, following a fragmented dose, the influence of body weight on the pharmacokinetic response (iAUC) over a 210 min period was absent (r = −0.168; p = 0.478), in contrast to the fixed or weight-relative dose. The pharmacokinetic response also seemed more homogenous (CV% = 26%) following a fragmented dose compared to the fixed (33%) and the weight-relative dose (31%). The primary advantage of the easy-to-calculate fragmented dosing strategy is that it does not systematically favour or impair a certain weight group. Thorough dosage studies are lacking in the current field of sports and food supplements, therefore similar considerations can be made towards other (ergogenic) food supplements.
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spelling pubmed-69504002020-01-16 Fragmented Dosing of β-alanine Induces A Body Weight-Independent Pharmacokinetic Response Stautemas, Jan Van de Loock, Alexia Van der Stede, Thibaux Pringels, Lauren Derave, Wim Nutrients Article Personalised dosing of performance-enhancing food supplements is a hot topic. β-alanine is currently dosed using a fixed dose; however, evidence suggests that this might favour light compared to heavy subjects. A weight-relative dose seems to reverse this problem. In the present study, a novel dosing strategy was tested. A fragmented dose, composed of a fixed fragment of 800 mg and a weight-relative fragment of 10 mg/kg body weight, was compared to a fixed dose of 1600 mg and a weight-relative dose of 20 mg/kg body weight in a cohort of 20 subjects with a body weight ranging 48–139 kg (79.9 ± 24.4 kg). The results show that, following a fragmented dose, the influence of body weight on the pharmacokinetic response (iAUC) over a 210 min period was absent (r = −0.168; p = 0.478), in contrast to the fixed or weight-relative dose. The pharmacokinetic response also seemed more homogenous (CV% = 26%) following a fragmented dose compared to the fixed (33%) and the weight-relative dose (31%). The primary advantage of the easy-to-calculate fragmented dosing strategy is that it does not systematically favour or impair a certain weight group. Thorough dosage studies are lacking in the current field of sports and food supplements, therefore similar considerations can be made towards other (ergogenic) food supplements. MDPI 2019-11-23 /pmc/articles/PMC6950400/ /pubmed/31771148 http://dx.doi.org/10.3390/nu11122869 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Stautemas, Jan
Van de Loock, Alexia
Van der Stede, Thibaux
Pringels, Lauren
Derave, Wim
Fragmented Dosing of β-alanine Induces A Body Weight-Independent Pharmacokinetic Response
title Fragmented Dosing of β-alanine Induces A Body Weight-Independent Pharmacokinetic Response
title_full Fragmented Dosing of β-alanine Induces A Body Weight-Independent Pharmacokinetic Response
title_fullStr Fragmented Dosing of β-alanine Induces A Body Weight-Independent Pharmacokinetic Response
title_full_unstemmed Fragmented Dosing of β-alanine Induces A Body Weight-Independent Pharmacokinetic Response
title_short Fragmented Dosing of β-alanine Induces A Body Weight-Independent Pharmacokinetic Response
title_sort fragmented dosing of β-alanine induces a body weight-independent pharmacokinetic response
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950400/
https://www.ncbi.nlm.nih.gov/pubmed/31771148
http://dx.doi.org/10.3390/nu11122869
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