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Berberis aristata, Elaeis guineensis and Coffea canephora Extracts Modulate the Insulin Receptor Expression and Improve Hepatic Steatosis in NAFLD Patients: A Pilot Clinical Trial

Non-alcoholic fatty liver disease (NAFLD) is associated with insulin resistance and diabetes. A reduction in insulin receptor (IR) expression has been reported in these patients. The aims of this study were to evaluate the effects of a mixture of plant extracts consisting of Berberis aristata, Elaei...

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Autores principales: Cossiga, Valentina, Lembo, Vincenzo, Guarino, Maria, Tuccillo, Concetta, Morando, Federica, Pontillo, Giuseppina, Fiorentino, Andrea, Caporaso, Nicola, Morisco, Filomena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950467/
https://www.ncbi.nlm.nih.gov/pubmed/31888241
http://dx.doi.org/10.3390/nu11123070
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author Cossiga, Valentina
Lembo, Vincenzo
Guarino, Maria
Tuccillo, Concetta
Morando, Federica
Pontillo, Giuseppina
Fiorentino, Andrea
Caporaso, Nicola
Morisco, Filomena
author_facet Cossiga, Valentina
Lembo, Vincenzo
Guarino, Maria
Tuccillo, Concetta
Morando, Federica
Pontillo, Giuseppina
Fiorentino, Andrea
Caporaso, Nicola
Morisco, Filomena
author_sort Cossiga, Valentina
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) is associated with insulin resistance and diabetes. A reduction in insulin receptor (IR) expression has been reported in these patients. The aims of this study were to evaluate the effects of a mixture of plant extracts consisting of Berberis aristata, Elaeis guineensis and decaffeinated green coffee by Coffea canephora on the improvement of glycaemic profile, through the modulation of IR levels, and of hepatic steatosis in NAFLD patients. Forty-nine patients with a grade of steatosis S1-S2 were randomly allocated to the treatment with plant extracts or placebo for six months. Hepatic steatosis was evaluated using transient elastography with CAP (controlled attenuation parameter). Glucose, insulin, and IR levels were measured in serum samples. At the end of the study, patients treated with plant extracts displayed a significant reduction of serum glucose (p < 0.001), insulin levels (p < 0.01), homeostatic model assessment for insulin resistance (HOMA-IR) index (p < 0.001), and CAP value (p < 0.01) compared to placebo. Moreover, the IR expression was increased significantly in the plant extracts group compared to the placebo group (p < 0.05). The combination of plant extracts increases serum IR levels, determining amelioration of glycemic profile and improvement of hepatic steatosis in NAFLD patients.
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spelling pubmed-69504672020-01-16 Berberis aristata, Elaeis guineensis and Coffea canephora Extracts Modulate the Insulin Receptor Expression and Improve Hepatic Steatosis in NAFLD Patients: A Pilot Clinical Trial Cossiga, Valentina Lembo, Vincenzo Guarino, Maria Tuccillo, Concetta Morando, Federica Pontillo, Giuseppina Fiorentino, Andrea Caporaso, Nicola Morisco, Filomena Nutrients Article Non-alcoholic fatty liver disease (NAFLD) is associated with insulin resistance and diabetes. A reduction in insulin receptor (IR) expression has been reported in these patients. The aims of this study were to evaluate the effects of a mixture of plant extracts consisting of Berberis aristata, Elaeis guineensis and decaffeinated green coffee by Coffea canephora on the improvement of glycaemic profile, through the modulation of IR levels, and of hepatic steatosis in NAFLD patients. Forty-nine patients with a grade of steatosis S1-S2 were randomly allocated to the treatment with plant extracts or placebo for six months. Hepatic steatosis was evaluated using transient elastography with CAP (controlled attenuation parameter). Glucose, insulin, and IR levels were measured in serum samples. At the end of the study, patients treated with plant extracts displayed a significant reduction of serum glucose (p < 0.001), insulin levels (p < 0.01), homeostatic model assessment for insulin resistance (HOMA-IR) index (p < 0.001), and CAP value (p < 0.01) compared to placebo. Moreover, the IR expression was increased significantly in the plant extracts group compared to the placebo group (p < 0.05). The combination of plant extracts increases serum IR levels, determining amelioration of glycemic profile and improvement of hepatic steatosis in NAFLD patients. MDPI 2019-12-16 /pmc/articles/PMC6950467/ /pubmed/31888241 http://dx.doi.org/10.3390/nu11123070 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cossiga, Valentina
Lembo, Vincenzo
Guarino, Maria
Tuccillo, Concetta
Morando, Federica
Pontillo, Giuseppina
Fiorentino, Andrea
Caporaso, Nicola
Morisco, Filomena
Berberis aristata, Elaeis guineensis and Coffea canephora Extracts Modulate the Insulin Receptor Expression and Improve Hepatic Steatosis in NAFLD Patients: A Pilot Clinical Trial
title Berberis aristata, Elaeis guineensis and Coffea canephora Extracts Modulate the Insulin Receptor Expression and Improve Hepatic Steatosis in NAFLD Patients: A Pilot Clinical Trial
title_full Berberis aristata, Elaeis guineensis and Coffea canephora Extracts Modulate the Insulin Receptor Expression and Improve Hepatic Steatosis in NAFLD Patients: A Pilot Clinical Trial
title_fullStr Berberis aristata, Elaeis guineensis and Coffea canephora Extracts Modulate the Insulin Receptor Expression and Improve Hepatic Steatosis in NAFLD Patients: A Pilot Clinical Trial
title_full_unstemmed Berberis aristata, Elaeis guineensis and Coffea canephora Extracts Modulate the Insulin Receptor Expression and Improve Hepatic Steatosis in NAFLD Patients: A Pilot Clinical Trial
title_short Berberis aristata, Elaeis guineensis and Coffea canephora Extracts Modulate the Insulin Receptor Expression and Improve Hepatic Steatosis in NAFLD Patients: A Pilot Clinical Trial
title_sort berberis aristata, elaeis guineensis and coffea canephora extracts modulate the insulin receptor expression and improve hepatic steatosis in nafld patients: a pilot clinical trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950467/
https://www.ncbi.nlm.nih.gov/pubmed/31888241
http://dx.doi.org/10.3390/nu11123070
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