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Dietary Omega-3 Fatty Acid Dampens Allergic Rhinitis via Eosinophilic Production of the Anti-Allergic Lipid Mediator 15-Hydroxyeicosapentaenoic Acid in Mice

The metabolism and generation of bioactive lipid mediators are key events in the exertion of the beneficial effects of dietary omega-3 fatty acids in the regulation of allergic inflammation. Here, we found that dietary linseed oil, which contains high amounts of alpha-linolenic acid (ALA) dampened a...

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Autores principales: Sawane, Kento, Nagatake, Takahiro, Hosomi, Koji, Hirata, So-ichiro, Adachi, Jun, Abe, Yuichi, Isoyama, Junko, Suzuki, Hidehiko, Matsunaga, Ayu, Fukumitsu, Satoshi, Aida, Kazuhiko, Tomonaga, Takeshi, Arita, Makoto, Kunisawa, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950470/
https://www.ncbi.nlm.nih.gov/pubmed/31766714
http://dx.doi.org/10.3390/nu11122868
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author Sawane, Kento
Nagatake, Takahiro
Hosomi, Koji
Hirata, So-ichiro
Adachi, Jun
Abe, Yuichi
Isoyama, Junko
Suzuki, Hidehiko
Matsunaga, Ayu
Fukumitsu, Satoshi
Aida, Kazuhiko
Tomonaga, Takeshi
Arita, Makoto
Kunisawa, Jun
author_facet Sawane, Kento
Nagatake, Takahiro
Hosomi, Koji
Hirata, So-ichiro
Adachi, Jun
Abe, Yuichi
Isoyama, Junko
Suzuki, Hidehiko
Matsunaga, Ayu
Fukumitsu, Satoshi
Aida, Kazuhiko
Tomonaga, Takeshi
Arita, Makoto
Kunisawa, Jun
author_sort Sawane, Kento
collection PubMed
description The metabolism and generation of bioactive lipid mediators are key events in the exertion of the beneficial effects of dietary omega-3 fatty acids in the regulation of allergic inflammation. Here, we found that dietary linseed oil, which contains high amounts of alpha-linolenic acid (ALA) dampened allergic rhinitis through eosinophilic production of 15-hydroxyeicosapentaenoic acid (15-HEPE), a metabolite of eicosapentaenoic acid (EPA). Lipidomic analysis revealed that 15-HEPE was particularly accumulated in the nasal passage of linseed oil-fed mice after the development of allergic rhinitis with the increasing number of eosinophils. Indeed, the conversion of EPA to 15-HEPE was mediated by the 15-lipoxygenase activity of eosinophils. Intranasal injection of 15-HEPE dampened allergic symptoms by inhibiting mast cell degranulation, which was mediated by the action of peroxisome proliferator-activated receptor gamma. These findings identify 15-HEPE as a novel EPA-derived, and eosinophil-dependent anti-allergic metabolite, and provide a preventive and therapeutic strategy against allergic rhinitis.
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spelling pubmed-69504702020-01-16 Dietary Omega-3 Fatty Acid Dampens Allergic Rhinitis via Eosinophilic Production of the Anti-Allergic Lipid Mediator 15-Hydroxyeicosapentaenoic Acid in Mice Sawane, Kento Nagatake, Takahiro Hosomi, Koji Hirata, So-ichiro Adachi, Jun Abe, Yuichi Isoyama, Junko Suzuki, Hidehiko Matsunaga, Ayu Fukumitsu, Satoshi Aida, Kazuhiko Tomonaga, Takeshi Arita, Makoto Kunisawa, Jun Nutrients Article The metabolism and generation of bioactive lipid mediators are key events in the exertion of the beneficial effects of dietary omega-3 fatty acids in the regulation of allergic inflammation. Here, we found that dietary linseed oil, which contains high amounts of alpha-linolenic acid (ALA) dampened allergic rhinitis through eosinophilic production of 15-hydroxyeicosapentaenoic acid (15-HEPE), a metabolite of eicosapentaenoic acid (EPA). Lipidomic analysis revealed that 15-HEPE was particularly accumulated in the nasal passage of linseed oil-fed mice after the development of allergic rhinitis with the increasing number of eosinophils. Indeed, the conversion of EPA to 15-HEPE was mediated by the 15-lipoxygenase activity of eosinophils. Intranasal injection of 15-HEPE dampened allergic symptoms by inhibiting mast cell degranulation, which was mediated by the action of peroxisome proliferator-activated receptor gamma. These findings identify 15-HEPE as a novel EPA-derived, and eosinophil-dependent anti-allergic metabolite, and provide a preventive and therapeutic strategy against allergic rhinitis. MDPI 2019-11-22 /pmc/articles/PMC6950470/ /pubmed/31766714 http://dx.doi.org/10.3390/nu11122868 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sawane, Kento
Nagatake, Takahiro
Hosomi, Koji
Hirata, So-ichiro
Adachi, Jun
Abe, Yuichi
Isoyama, Junko
Suzuki, Hidehiko
Matsunaga, Ayu
Fukumitsu, Satoshi
Aida, Kazuhiko
Tomonaga, Takeshi
Arita, Makoto
Kunisawa, Jun
Dietary Omega-3 Fatty Acid Dampens Allergic Rhinitis via Eosinophilic Production of the Anti-Allergic Lipid Mediator 15-Hydroxyeicosapentaenoic Acid in Mice
title Dietary Omega-3 Fatty Acid Dampens Allergic Rhinitis via Eosinophilic Production of the Anti-Allergic Lipid Mediator 15-Hydroxyeicosapentaenoic Acid in Mice
title_full Dietary Omega-3 Fatty Acid Dampens Allergic Rhinitis via Eosinophilic Production of the Anti-Allergic Lipid Mediator 15-Hydroxyeicosapentaenoic Acid in Mice
title_fullStr Dietary Omega-3 Fatty Acid Dampens Allergic Rhinitis via Eosinophilic Production of the Anti-Allergic Lipid Mediator 15-Hydroxyeicosapentaenoic Acid in Mice
title_full_unstemmed Dietary Omega-3 Fatty Acid Dampens Allergic Rhinitis via Eosinophilic Production of the Anti-Allergic Lipid Mediator 15-Hydroxyeicosapentaenoic Acid in Mice
title_short Dietary Omega-3 Fatty Acid Dampens Allergic Rhinitis via Eosinophilic Production of the Anti-Allergic Lipid Mediator 15-Hydroxyeicosapentaenoic Acid in Mice
title_sort dietary omega-3 fatty acid dampens allergic rhinitis via eosinophilic production of the anti-allergic lipid mediator 15-hydroxyeicosapentaenoic acid in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950470/
https://www.ncbi.nlm.nih.gov/pubmed/31766714
http://dx.doi.org/10.3390/nu11122868
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