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Further Evidence for in Utero Transmission of Equine Hepacivirus to Foals

(1) Background: Equine hepacivirus (EqHV), also referred to as non-primate hepacivirus (NPHV), infects horses—and dogs in some instances—and is closely related to hepatitis C virus (HCV) that has infected up to 3% of the world’s human population, causing an epidemic of liver cirrhosis and cancer. Eq...

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Autores principales: Pronost, Stephane, Fortier, Christine, Marcillaud-Pitel, Christel, Tapprest, Jackie, Foursin, Marc, Saunier, Bertrand, Pitel, Pierre-Hugues, Paillot, Romain, Hue, Erika S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950541/
https://www.ncbi.nlm.nih.gov/pubmed/31817371
http://dx.doi.org/10.3390/v11121124
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author Pronost, Stephane
Fortier, Christine
Marcillaud-Pitel, Christel
Tapprest, Jackie
Foursin, Marc
Saunier, Bertrand
Pitel, Pierre-Hugues
Paillot, Romain
Hue, Erika S.
author_facet Pronost, Stephane
Fortier, Christine
Marcillaud-Pitel, Christel
Tapprest, Jackie
Foursin, Marc
Saunier, Bertrand
Pitel, Pierre-Hugues
Paillot, Romain
Hue, Erika S.
author_sort Pronost, Stephane
collection PubMed
description (1) Background: Equine hepacivirus (EqHV), also referred to as non-primate hepacivirus (NPHV), infects horses—and dogs in some instances—and is closely related to hepatitis C virus (HCV) that has infected up to 3% of the world’s human population, causing an epidemic of liver cirrhosis and cancer. EqHV also chronically infects the liver of horses, but does not appear to cause serious liver damages. Previous studies have been looking to identify route(s) of EqHV transmission to and between horses. (2) Methods: In this retrospective study, we sought to evaluate the prevalence of vertical transmission taking place in utero with measuring by quantitative RT-PCR the amounts of EqHV genome in samples from 394 dead foals or fetuses, paired with the allantochorion whenever available. (3) Results: Detection of EqHV in three foals most likely resulted from a vertical transmission from the mares to the fetuses, consistent with the in utero transmission hypothesis. In support of this observation, the presence of EqHV genome was found for the first time in two of the allantochorions. (4) Conclusions: As seemingly benign viruses could turn deadly (e.g., Zika flavivirus) and EqHV happens to have infected a significant proportion of the world’s horse herds, EqHV infectious cycle should be further clarified.
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spelling pubmed-69505412020-01-16 Further Evidence for in Utero Transmission of Equine Hepacivirus to Foals Pronost, Stephane Fortier, Christine Marcillaud-Pitel, Christel Tapprest, Jackie Foursin, Marc Saunier, Bertrand Pitel, Pierre-Hugues Paillot, Romain Hue, Erika S. Viruses Communication (1) Background: Equine hepacivirus (EqHV), also referred to as non-primate hepacivirus (NPHV), infects horses—and dogs in some instances—and is closely related to hepatitis C virus (HCV) that has infected up to 3% of the world’s human population, causing an epidemic of liver cirrhosis and cancer. EqHV also chronically infects the liver of horses, but does not appear to cause serious liver damages. Previous studies have been looking to identify route(s) of EqHV transmission to and between horses. (2) Methods: In this retrospective study, we sought to evaluate the prevalence of vertical transmission taking place in utero with measuring by quantitative RT-PCR the amounts of EqHV genome in samples from 394 dead foals or fetuses, paired with the allantochorion whenever available. (3) Results: Detection of EqHV in three foals most likely resulted from a vertical transmission from the mares to the fetuses, consistent with the in utero transmission hypothesis. In support of this observation, the presence of EqHV genome was found for the first time in two of the allantochorions. (4) Conclusions: As seemingly benign viruses could turn deadly (e.g., Zika flavivirus) and EqHV happens to have infected a significant proportion of the world’s horse herds, EqHV infectious cycle should be further clarified. MDPI 2019-12-05 /pmc/articles/PMC6950541/ /pubmed/31817371 http://dx.doi.org/10.3390/v11121124 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Pronost, Stephane
Fortier, Christine
Marcillaud-Pitel, Christel
Tapprest, Jackie
Foursin, Marc
Saunier, Bertrand
Pitel, Pierre-Hugues
Paillot, Romain
Hue, Erika S.
Further Evidence for in Utero Transmission of Equine Hepacivirus to Foals
title Further Evidence for in Utero Transmission of Equine Hepacivirus to Foals
title_full Further Evidence for in Utero Transmission of Equine Hepacivirus to Foals
title_fullStr Further Evidence for in Utero Transmission of Equine Hepacivirus to Foals
title_full_unstemmed Further Evidence for in Utero Transmission of Equine Hepacivirus to Foals
title_short Further Evidence for in Utero Transmission of Equine Hepacivirus to Foals
title_sort further evidence for in utero transmission of equine hepacivirus to foals
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950541/
https://www.ncbi.nlm.nih.gov/pubmed/31817371
http://dx.doi.org/10.3390/v11121124
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