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The Correlation of Central Serous Chorioretinopathy and Subsequent Cardiovascular Diseases of Different Types: A Population-Based Cohort Study

The aim of the present study was to survey the relationship between central serous chorioretinopathy (CSC) and several cardiovascular diseases (CVDs) with different severities using the National Health Insurance Research Database. A retrospective cohort study was conducted. Subjects with CSC were en...

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Autores principales: Hsu, Hung-Jui, Lee, Chia-Yi, Chao, Shih-Chun, Nien, Chan-Wei, Tzeng, Shih-Hao, Huang, Jing-Yang, Ko, Tai-Chuan, Yang, Shun-Fa, Lin, Hung-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950554/
https://www.ncbi.nlm.nih.gov/pubmed/31847232
http://dx.doi.org/10.3390/ijerph16245099
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author Hsu, Hung-Jui
Lee, Chia-Yi
Chao, Shih-Chun
Nien, Chan-Wei
Tzeng, Shih-Hao
Huang, Jing-Yang
Ko, Tai-Chuan
Yang, Shun-Fa
Lin, Hung-Yu
author_facet Hsu, Hung-Jui
Lee, Chia-Yi
Chao, Shih-Chun
Nien, Chan-Wei
Tzeng, Shih-Hao
Huang, Jing-Yang
Ko, Tai-Chuan
Yang, Shun-Fa
Lin, Hung-Yu
author_sort Hsu, Hung-Jui
collection PubMed
description The aim of the present study was to survey the relationship between central serous chorioretinopathy (CSC) and several cardiovascular diseases (CVDs) with different severities using the National Health Insurance Research Database. A retrospective cohort study was conducted. Subjects with CSC were enrolled according to the relevant diagnostic codes, and an age- and gender-matched population was used as the control group with a 1:4 ratio. The main outcome being considered was the development of CVD after CSC exposure. Cox proportional hazard regression was applied to calculate the adjusted hazard ratio (aHR) of CSC and CVD of different types. A total of 2865 patients that were diagnosed with CSC were enrolled in the study group, while another 11,460 non-CSC subjects were selected as the control group. There were 171 events of CVD which occurred in the study group, while another 557 cases were found in the control group. No significant differences were observed among the CVD cases between the study and control group, whether they had an acute or chronic form, according to the aHR. In the subgroup analysis, there was a significantly higher risk of CVD development in the male population aged from 40 to 59 years (aHR: 1.351, confidence interval (CI): 1.063–1.716), which was mainly due to the higher risk of mild CVD (aHR: 1.391, CI: 1.062–1.822). On the contrary, there was no significant difference in CVD development in any of the age subgroups of the female population. In conclusion, the existence of CSC is correlated with a higher rate of chronic CVD occurrence in the middle-aged male population.
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spelling pubmed-69505542020-01-16 The Correlation of Central Serous Chorioretinopathy and Subsequent Cardiovascular Diseases of Different Types: A Population-Based Cohort Study Hsu, Hung-Jui Lee, Chia-Yi Chao, Shih-Chun Nien, Chan-Wei Tzeng, Shih-Hao Huang, Jing-Yang Ko, Tai-Chuan Yang, Shun-Fa Lin, Hung-Yu Int J Environ Res Public Health Article The aim of the present study was to survey the relationship between central serous chorioretinopathy (CSC) and several cardiovascular diseases (CVDs) with different severities using the National Health Insurance Research Database. A retrospective cohort study was conducted. Subjects with CSC were enrolled according to the relevant diagnostic codes, and an age- and gender-matched population was used as the control group with a 1:4 ratio. The main outcome being considered was the development of CVD after CSC exposure. Cox proportional hazard regression was applied to calculate the adjusted hazard ratio (aHR) of CSC and CVD of different types. A total of 2865 patients that were diagnosed with CSC were enrolled in the study group, while another 11,460 non-CSC subjects were selected as the control group. There were 171 events of CVD which occurred in the study group, while another 557 cases were found in the control group. No significant differences were observed among the CVD cases between the study and control group, whether they had an acute or chronic form, according to the aHR. In the subgroup analysis, there was a significantly higher risk of CVD development in the male population aged from 40 to 59 years (aHR: 1.351, confidence interval (CI): 1.063–1.716), which was mainly due to the higher risk of mild CVD (aHR: 1.391, CI: 1.062–1.822). On the contrary, there was no significant difference in CVD development in any of the age subgroups of the female population. In conclusion, the existence of CSC is correlated with a higher rate of chronic CVD occurrence in the middle-aged male population. MDPI 2019-12-13 2019-12 /pmc/articles/PMC6950554/ /pubmed/31847232 http://dx.doi.org/10.3390/ijerph16245099 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hsu, Hung-Jui
Lee, Chia-Yi
Chao, Shih-Chun
Nien, Chan-Wei
Tzeng, Shih-Hao
Huang, Jing-Yang
Ko, Tai-Chuan
Yang, Shun-Fa
Lin, Hung-Yu
The Correlation of Central Serous Chorioretinopathy and Subsequent Cardiovascular Diseases of Different Types: A Population-Based Cohort Study
title The Correlation of Central Serous Chorioretinopathy and Subsequent Cardiovascular Diseases of Different Types: A Population-Based Cohort Study
title_full The Correlation of Central Serous Chorioretinopathy and Subsequent Cardiovascular Diseases of Different Types: A Population-Based Cohort Study
title_fullStr The Correlation of Central Serous Chorioretinopathy and Subsequent Cardiovascular Diseases of Different Types: A Population-Based Cohort Study
title_full_unstemmed The Correlation of Central Serous Chorioretinopathy and Subsequent Cardiovascular Diseases of Different Types: A Population-Based Cohort Study
title_short The Correlation of Central Serous Chorioretinopathy and Subsequent Cardiovascular Diseases of Different Types: A Population-Based Cohort Study
title_sort correlation of central serous chorioretinopathy and subsequent cardiovascular diseases of different types: a population-based cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950554/
https://www.ncbi.nlm.nih.gov/pubmed/31847232
http://dx.doi.org/10.3390/ijerph16245099
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