Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction

This review focuses on mechanisms of calorie restriction (CR), particularly the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis as an evolutionary conserved signal that regulates aging and lifespan, underlying the effects of CR in mammals. Topics include (1) the relation of the GH-IGF-...

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Detalles Bibliográficos
Autores principales: Komatsu, Toshimitsu, Park, Seongjoon, Hayashi, Hiroko, Mori, Ryoichi, Yamaza, Haruyoshi, Shimokawa, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950657/
https://www.ncbi.nlm.nih.gov/pubmed/31888201
http://dx.doi.org/10.3390/nu11123068

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