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Recent Advances in Nanoencapsulation Systems Using PLGA of Bioactive Phenolics for Protection against Chronic Diseases
Plant-derived polyphenolic compounds have gained widespread recognition as remarkable nutraceuticals for the prevention and treatment of various disorders, such as cardiovascular, neurodegenerative, diabetes, osteoporosis, and neoplastic diseases. Evidence from the epidemiological studies has sugges...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950714/ https://www.ncbi.nlm.nih.gov/pubmed/31817699 http://dx.doi.org/10.3390/ijerph16244962 |
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author | Abdul Rahim, Rohanizah Jayusman, Putri Ayu Muhammad, Norliza Ahmad, Fairus Mokhtar, Norfilza Naina Mohamed, Isa Mohamed, Norazlina Shuid, Ahmad Nazrun |
author_facet | Abdul Rahim, Rohanizah Jayusman, Putri Ayu Muhammad, Norliza Ahmad, Fairus Mokhtar, Norfilza Naina Mohamed, Isa Mohamed, Norazlina Shuid, Ahmad Nazrun |
author_sort | Abdul Rahim, Rohanizah |
collection | PubMed |
description | Plant-derived polyphenolic compounds have gained widespread recognition as remarkable nutraceuticals for the prevention and treatment of various disorders, such as cardiovascular, neurodegenerative, diabetes, osteoporosis, and neoplastic diseases. Evidence from the epidemiological studies has suggested the association between long-term consumption of diets rich in polyphenols and protection against chronic diseases. Nevertheless, the applications of these phytochemicals are limited due to its low solubility, low bioavailability, instability, and degradability by in vivo and in vitro conditions. Therefore, in recent years, newer approaches have been attempted to solve the restrictions related to their delivery system. Nanoencapsulation of phenolic compounds with biopolymeric nanoparticles could be a promising strategy for protection and effective delivery of phenolics. Poly(lactic-co-glycolic acid) (PLGA) is one of the most successfully developed biodegradable polymers that has attracted considerable attention due to its attractive properties. In this review, our main goal is to cover the relevant recent studies that explore the pharmaceutical significance and therapeutic superiority of the advance delivery systems of phenolic compounds using PLGA-based nanoparticles. A summary of the recent studies implementing encapsulation techniques applied to polyphenolic compounds from plants confirmed that nanoencapsulation with PLGA nanoparticles is a promising approach to potentialize their therapeutic activity. |
format | Online Article Text |
id | pubmed-6950714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69507142020-01-16 Recent Advances in Nanoencapsulation Systems Using PLGA of Bioactive Phenolics for Protection against Chronic Diseases Abdul Rahim, Rohanizah Jayusman, Putri Ayu Muhammad, Norliza Ahmad, Fairus Mokhtar, Norfilza Naina Mohamed, Isa Mohamed, Norazlina Shuid, Ahmad Nazrun Int J Environ Res Public Health Review Plant-derived polyphenolic compounds have gained widespread recognition as remarkable nutraceuticals for the prevention and treatment of various disorders, such as cardiovascular, neurodegenerative, diabetes, osteoporosis, and neoplastic diseases. Evidence from the epidemiological studies has suggested the association between long-term consumption of diets rich in polyphenols and protection against chronic diseases. Nevertheless, the applications of these phytochemicals are limited due to its low solubility, low bioavailability, instability, and degradability by in vivo and in vitro conditions. Therefore, in recent years, newer approaches have been attempted to solve the restrictions related to their delivery system. Nanoencapsulation of phenolic compounds with biopolymeric nanoparticles could be a promising strategy for protection and effective delivery of phenolics. Poly(lactic-co-glycolic acid) (PLGA) is one of the most successfully developed biodegradable polymers that has attracted considerable attention due to its attractive properties. In this review, our main goal is to cover the relevant recent studies that explore the pharmaceutical significance and therapeutic superiority of the advance delivery systems of phenolic compounds using PLGA-based nanoparticles. A summary of the recent studies implementing encapsulation techniques applied to polyphenolic compounds from plants confirmed that nanoencapsulation with PLGA nanoparticles is a promising approach to potentialize their therapeutic activity. MDPI 2019-12-06 2019-12 /pmc/articles/PMC6950714/ /pubmed/31817699 http://dx.doi.org/10.3390/ijerph16244962 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Abdul Rahim, Rohanizah Jayusman, Putri Ayu Muhammad, Norliza Ahmad, Fairus Mokhtar, Norfilza Naina Mohamed, Isa Mohamed, Norazlina Shuid, Ahmad Nazrun Recent Advances in Nanoencapsulation Systems Using PLGA of Bioactive Phenolics for Protection against Chronic Diseases |
title | Recent Advances in Nanoencapsulation Systems Using PLGA of Bioactive Phenolics for Protection against Chronic Diseases |
title_full | Recent Advances in Nanoencapsulation Systems Using PLGA of Bioactive Phenolics for Protection against Chronic Diseases |
title_fullStr | Recent Advances in Nanoencapsulation Systems Using PLGA of Bioactive Phenolics for Protection against Chronic Diseases |
title_full_unstemmed | Recent Advances in Nanoencapsulation Systems Using PLGA of Bioactive Phenolics for Protection against Chronic Diseases |
title_short | Recent Advances in Nanoencapsulation Systems Using PLGA of Bioactive Phenolics for Protection against Chronic Diseases |
title_sort | recent advances in nanoencapsulation systems using plga of bioactive phenolics for protection against chronic diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950714/ https://www.ncbi.nlm.nih.gov/pubmed/31817699 http://dx.doi.org/10.3390/ijerph16244962 |
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