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HTLV-1 bZIP factor: the key viral gene for pathogenesis

Human T cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL) and inflammatory diseases. The HTLV-1 bZIP factor (HBZ) gene is constantly expressed in HTLV-1 infected cells and ATL cells. HBZ protein suppresses transcription of the tax gene through blocking the LTR recruitme...

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Autores principales: Matsuoka, Masao, Mesnard, Jean-Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950816/
https://www.ncbi.nlm.nih.gov/pubmed/31915026
http://dx.doi.org/10.1186/s12977-020-0511-0
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author Matsuoka, Masao
Mesnard, Jean-Michel
author_facet Matsuoka, Masao
Mesnard, Jean-Michel
author_sort Matsuoka, Masao
collection PubMed
description Human T cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL) and inflammatory diseases. The HTLV-1 bZIP factor (HBZ) gene is constantly expressed in HTLV-1 infected cells and ATL cells. HBZ protein suppresses transcription of the tax gene through blocking the LTR recruitment of not only ATF/CREB factors but also CBP/p300. HBZ promotes transcription of Foxp3, CCR4, and T-cell immunoreceptor with Ig and ITIM domains (TIGIT). Thus, HBZ is critical for the immunophenotype of infected cells and ATL cells. HBZ also functions in its RNA form. HBZ RNA suppresses apoptosis and promotes proliferation of T cells. Since HBZ RNA is not recognized by cytotoxic T cells, HTLV-1 has a clever strategy for avoiding immune detection. HBZ plays central roles in maintaining infected T cells in vivo and determining their immunophenotype.
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spelling pubmed-69508162020-01-09 HTLV-1 bZIP factor: the key viral gene for pathogenesis Matsuoka, Masao Mesnard, Jean-Michel Retrovirology Review Human T cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia-lymphoma (ATL) and inflammatory diseases. The HTLV-1 bZIP factor (HBZ) gene is constantly expressed in HTLV-1 infected cells and ATL cells. HBZ protein suppresses transcription of the tax gene through blocking the LTR recruitment of not only ATF/CREB factors but also CBP/p300. HBZ promotes transcription of Foxp3, CCR4, and T-cell immunoreceptor with Ig and ITIM domains (TIGIT). Thus, HBZ is critical for the immunophenotype of infected cells and ATL cells. HBZ also functions in its RNA form. HBZ RNA suppresses apoptosis and promotes proliferation of T cells. Since HBZ RNA is not recognized by cytotoxic T cells, HTLV-1 has a clever strategy for avoiding immune detection. HBZ plays central roles in maintaining infected T cells in vivo and determining their immunophenotype. BioMed Central 2020-01-08 /pmc/articles/PMC6950816/ /pubmed/31915026 http://dx.doi.org/10.1186/s12977-020-0511-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Matsuoka, Masao
Mesnard, Jean-Michel
HTLV-1 bZIP factor: the key viral gene for pathogenesis
title HTLV-1 bZIP factor: the key viral gene for pathogenesis
title_full HTLV-1 bZIP factor: the key viral gene for pathogenesis
title_fullStr HTLV-1 bZIP factor: the key viral gene for pathogenesis
title_full_unstemmed HTLV-1 bZIP factor: the key viral gene for pathogenesis
title_short HTLV-1 bZIP factor: the key viral gene for pathogenesis
title_sort htlv-1 bzip factor: the key viral gene for pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950816/
https://www.ncbi.nlm.nih.gov/pubmed/31915026
http://dx.doi.org/10.1186/s12977-020-0511-0
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