Strains used in whole organism Plasmodium falciparum vaccine trials differ in genome structure, sequence, and immunogenic potential

BACKGROUND: Plasmodium falciparum (Pf) whole-organism sporozoite vaccines have been shown to provide significant protection against controlled human malaria infection (CHMI) in clinical trials. Initial CHMI studies showed significantly higher durable protection against homologous than heterologous s...

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Detalles Bibliográficos
Autores principales: Moser, Kara A., Drábek, Elliott F., Dwivedi, Ankit, Stucke, Emily M., Crabtree, Jonathan, Dara, Antoine, Shah, Zalak, Adams, Matthew, Li, Tao, Rodrigues, Priscila T., Koren, Sergey, Phillippy, Adam M., Munro, James B., Ouattara, Amed, Sparklin, Benjamin C., Dunning Hotopp, Julie C., Lyke, Kirsten E., Sadzewicz, Lisa, Tallon, Luke J., Spring, Michele D., Jongsakul, Krisada, Lon, Chanthap, Saunders, David L., Ferreira, Marcelo U., Nyunt, Myaing M., Laufer, Miriam K., Travassos, Mark A., Sauerwein, Robert W., Takala-Harrison, Shannon, Fraser, Claire M., Sim, B. Kim Lee, Hoffman, Stephen L., Plowe, Christopher V., Silva, Joana C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950926/
https://www.ncbi.nlm.nih.gov/pubmed/31915075
http://dx.doi.org/10.1186/s13073-019-0708-9

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