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The effect of inspiratory parameters after two separate inhalations on the dose emission of theophylline from low and high resistance dry powder inhalers

The dose emission from DPIs can be affected by the inspiratory parameters achieved by the patient as well as the device in-use. Conventional in-vitro dose emission methodology was used, but instead of using inhalation volume (Vin) of 2 or 4 L and peak inhalation flow (PIF) corresponding to 4 kPa, a...

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Detalles Bibliográficos
Autores principales: Abadelah, Mohamad, Al-Assadi, Jumannah, Rooney, James, Larhrib, Hassane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950967/
https://www.ncbi.nlm.nih.gov/pubmed/31920434
http://dx.doi.org/10.1016/j.jsps.2019.11.007