DNA methylation changes in Down syndrome derived neural iPSCs uncover co-dysregulation of ZNF and HOX3 families of transcription factors

BACKGROUND: Down syndrome (DS) is characterized by neurodevelopmental abnormalities caused by partial or complete trisomy of human chromosome 21 (T21). Analysis of Down syndrome brain specimens has shown global epigenetic and transcriptional changes but their interplay during early neurogenesis rema...

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Detalles Bibliográficos
Autores principales: Laan, Loora, Klar, Joakim, Sobol, Maria, Hoeber, Jan, Shahsavani, Mansoureh, Kele, Malin, Fatima, Ambrin, Zakaria, Muhammad, Annerén, Göran, Falk, Anna, Schuster, Jens, Dahl, Niklas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6950999/
https://www.ncbi.nlm.nih.gov/pubmed/31915063
http://dx.doi.org/10.1186/s13148-019-0803-1

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