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Brachial‐Ankle Pulse Wave Velocity Versus Its Stiffness Index β‐Transformed Value as Risk Marker for Cardiovascular Disease
BACKGROUND: The difference in the predictive ability of the brachial‐ankle pulse wave velocity (baPWV) and its stiffness index β‐transformed value (β‐baPWV, ie, baPWV adjusted for the pulse pressure) for the development of pathophysiological abnormalities related to cardiovascular disease or future...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951050/ https://www.ncbi.nlm.nih.gov/pubmed/31822217 http://dx.doi.org/10.1161/JAHA.119.013004 |
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author | Tomiyama, Hirofumi Ohkuma, Toshiaki Ninomiya, Toshiharu Nakano, Hiroki Matsumoto, Chisa Avolio, Alberto Kohro, Takahide Higashi, Yukihito Maruhashi, Tatsuya Takase, Bonpei Suzuki, Toru Ishizu, Tomoko Ueda, Shinichiro Yamazaki, Tsutomu Furumoto, Tomoo Kario, Kazuomi Inoue, Teruo Koba, Shinji Takemoto, Yasuhiko Hano, Takuzo Sata, Masataka Ishibashi, Yutaka Node, Koichi Maemura, Koji Ohya, Yusuke Furukawa, Taiji Ito, Hiroshi Chikamori, Taishiro Yamashina, Akira |
author_facet | Tomiyama, Hirofumi Ohkuma, Toshiaki Ninomiya, Toshiharu Nakano, Hiroki Matsumoto, Chisa Avolio, Alberto Kohro, Takahide Higashi, Yukihito Maruhashi, Tatsuya Takase, Bonpei Suzuki, Toru Ishizu, Tomoko Ueda, Shinichiro Yamazaki, Tsutomu Furumoto, Tomoo Kario, Kazuomi Inoue, Teruo Koba, Shinji Takemoto, Yasuhiko Hano, Takuzo Sata, Masataka Ishibashi, Yutaka Node, Koichi Maemura, Koji Ohya, Yusuke Furukawa, Taiji Ito, Hiroshi Chikamori, Taishiro Yamashina, Akira |
author_sort | Tomiyama, Hirofumi |
collection | PubMed |
description | BACKGROUND: The difference in the predictive ability of the brachial‐ankle pulse wave velocity (baPWV) and its stiffness index β‐transformed value (β‐baPWV, ie, baPWV adjusted for the pulse pressure) for the development of pathophysiological abnormalities related to cardiovascular disease or future occurrence of cardiovascular disease was examined. METHODS AND RESULTS: In study 1, a 7‐year prospective observational study in cohorts of 3274 men and 3490 men, the area under the curve in the receiver operator characteristic curve analysis was higher for baPWV than for β‐baPWV for predicting the development of hypertension (0.73, 95% CI=0.70 to 0.75 versus 0.59, 95% CI=0.56 to 0.62; P<0.01) and/or the development of retinopathy (0.78, 95% CI=0.73 to 0.82 versus 0.66, 95% CI=0.60 to 0.71; P<0.01) by the end of the study period. During study 2, a 3‐year observation period on 511 patients with coronary artery disease, 72 cardiovascular events were confirmed. The C statistics of both markers for predicting the development of cardiovascular events were similar. CONCLUSIONS: Stiffness index β transformation of the baPWV may attenuate the significance of the baPWV as a risk marker for development of pathophysiological abnormalities related to cardiovascular disease in male subjects. |
format | Online Article Text |
id | pubmed-6951050 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69510502020-01-10 Brachial‐Ankle Pulse Wave Velocity Versus Its Stiffness Index β‐Transformed Value as Risk Marker for Cardiovascular Disease Tomiyama, Hirofumi Ohkuma, Toshiaki Ninomiya, Toshiharu Nakano, Hiroki Matsumoto, Chisa Avolio, Alberto Kohro, Takahide Higashi, Yukihito Maruhashi, Tatsuya Takase, Bonpei Suzuki, Toru Ishizu, Tomoko Ueda, Shinichiro Yamazaki, Tsutomu Furumoto, Tomoo Kario, Kazuomi Inoue, Teruo Koba, Shinji Takemoto, Yasuhiko Hano, Takuzo Sata, Masataka Ishibashi, Yutaka Node, Koichi Maemura, Koji Ohya, Yusuke Furukawa, Taiji Ito, Hiroshi Chikamori, Taishiro Yamashina, Akira J Am Heart Assoc Original Research BACKGROUND: The difference in the predictive ability of the brachial‐ankle pulse wave velocity (baPWV) and its stiffness index β‐transformed value (β‐baPWV, ie, baPWV adjusted for the pulse pressure) for the development of pathophysiological abnormalities related to cardiovascular disease or future occurrence of cardiovascular disease was examined. METHODS AND RESULTS: In study 1, a 7‐year prospective observational study in cohorts of 3274 men and 3490 men, the area under the curve in the receiver operator characteristic curve analysis was higher for baPWV than for β‐baPWV for predicting the development of hypertension (0.73, 95% CI=0.70 to 0.75 versus 0.59, 95% CI=0.56 to 0.62; P<0.01) and/or the development of retinopathy (0.78, 95% CI=0.73 to 0.82 versus 0.66, 95% CI=0.60 to 0.71; P<0.01) by the end of the study period. During study 2, a 3‐year observation period on 511 patients with coronary artery disease, 72 cardiovascular events were confirmed. The C statistics of both markers for predicting the development of cardiovascular events were similar. CONCLUSIONS: Stiffness index β transformation of the baPWV may attenuate the significance of the baPWV as a risk marker for development of pathophysiological abnormalities related to cardiovascular disease in male subjects. John Wiley and Sons Inc. 2019-12-11 /pmc/articles/PMC6951050/ /pubmed/31822217 http://dx.doi.org/10.1161/JAHA.119.013004 Text en © 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Research Tomiyama, Hirofumi Ohkuma, Toshiaki Ninomiya, Toshiharu Nakano, Hiroki Matsumoto, Chisa Avolio, Alberto Kohro, Takahide Higashi, Yukihito Maruhashi, Tatsuya Takase, Bonpei Suzuki, Toru Ishizu, Tomoko Ueda, Shinichiro Yamazaki, Tsutomu Furumoto, Tomoo Kario, Kazuomi Inoue, Teruo Koba, Shinji Takemoto, Yasuhiko Hano, Takuzo Sata, Masataka Ishibashi, Yutaka Node, Koichi Maemura, Koji Ohya, Yusuke Furukawa, Taiji Ito, Hiroshi Chikamori, Taishiro Yamashina, Akira Brachial‐Ankle Pulse Wave Velocity Versus Its Stiffness Index β‐Transformed Value as Risk Marker for Cardiovascular Disease |
title | Brachial‐Ankle Pulse Wave Velocity Versus Its Stiffness Index β‐Transformed Value as Risk Marker for Cardiovascular Disease |
title_full | Brachial‐Ankle Pulse Wave Velocity Versus Its Stiffness Index β‐Transformed Value as Risk Marker for Cardiovascular Disease |
title_fullStr | Brachial‐Ankle Pulse Wave Velocity Versus Its Stiffness Index β‐Transformed Value as Risk Marker for Cardiovascular Disease |
title_full_unstemmed | Brachial‐Ankle Pulse Wave Velocity Versus Its Stiffness Index β‐Transformed Value as Risk Marker for Cardiovascular Disease |
title_short | Brachial‐Ankle Pulse Wave Velocity Versus Its Stiffness Index β‐Transformed Value as Risk Marker for Cardiovascular Disease |
title_sort | brachial‐ankle pulse wave velocity versus its stiffness index β‐transformed value as risk marker for cardiovascular disease |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951050/ https://www.ncbi.nlm.nih.gov/pubmed/31822217 http://dx.doi.org/10.1161/JAHA.119.013004 |
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