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Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA

BACKGROUND: cGMP mediates numerous cardioprotective functions and is a potential therapeutic target for cardiovascular disease. Preclinical studies suggest that plasma cGMP is reflective of natriuretic peptide stimulation. Epidemiologic associations between cGMP and natriuretic peptide, as well as c...

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Autores principales: Ying, Wendy, Zhao, Di, Ouyang, Pamela, Subramanya, Vinita, Vaidya, Dhananjay, Ndumele, Chiadi E., Guallar, Eliseo, Sharma, Kavita, Shah, Sanjiv J., Kass, David A., Hoogeveen, Ron C., Lima, Joao A., Heckbert, Susan R., deFilippi, Christopher R., Post, Wendy S., Michos, Erin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951064/
https://www.ncbi.nlm.nih.gov/pubmed/31838972
http://dx.doi.org/10.1161/JAHA.119.013149
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author Ying, Wendy
Zhao, Di
Ouyang, Pamela
Subramanya, Vinita
Vaidya, Dhananjay
Ndumele, Chiadi E.
Guallar, Eliseo
Sharma, Kavita
Shah, Sanjiv J.
Kass, David A.
Hoogeveen, Ron C.
Lima, Joao A.
Heckbert, Susan R.
deFilippi, Christopher R.
Post, Wendy S.
Michos, Erin D.
author_facet Ying, Wendy
Zhao, Di
Ouyang, Pamela
Subramanya, Vinita
Vaidya, Dhananjay
Ndumele, Chiadi E.
Guallar, Eliseo
Sharma, Kavita
Shah, Sanjiv J.
Kass, David A.
Hoogeveen, Ron C.
Lima, Joao A.
Heckbert, Susan R.
deFilippi, Christopher R.
Post, Wendy S.
Michos, Erin D.
author_sort Ying, Wendy
collection PubMed
description BACKGROUND: cGMP mediates numerous cardioprotective functions and is a potential therapeutic target for cardiovascular disease. Preclinical studies suggest that plasma cGMP is reflective of natriuretic peptide stimulation. Epidemiologic associations between cGMP and natriuretic peptide, as well as cardiovascular disease risk factors, are unknown. METHODS AND RESULTS: We measured plasma cGMP in 542 men and 496 women free of cardiovascular disease and heart failure in MESA (Multi‐Ethnic Study of Atherosclerosis). Cross‐sectional associations of N‐terminal pro‐B type natriuretic peptide, sex hormones, and cardiovascular disease/heart failure risk factors with log(cGMP) were analyzed using multivariable linear regression models. Mean (SD) cGMP was 4.7 (2.6) pmol/mL, with no difference between the sexes. After adjusting for cardiovascular risk factors, N‐terminal pro‐B type natriuretic peptide was significantly positively associated with cGMP (P<0.05). Higher blood pressure and lower estimated glomerular filtration rate were associated with higher cGMP (P<0.05). Triglyceride levels, total/high‐density lipoprotein cholesterol ratio, presence of diabetes mellitus, and the homeostatic model assessment of insulin resistance were inversely associated with cGMP (P<0.05). Among women, free testosterone and dehydroepiandrosterone were inversely associated with cGMP, while sex hormone binding globulin was positively associated (P<0.05). CONCLUSIONS: In a community‐cohort, plasma cGMP was associated with natriuretic peptide signaling. Higher blood pressure and greater renal dysfunction were positively associated with cGMP, while adverse metabolic risk factors were inversely associated. Increased androgenicity in postmenopausal women was inversely associated with cGMP. These novel associations further our understanding of the role of cGMP in a general population.
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spelling pubmed-69510642020-01-10 Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA Ying, Wendy Zhao, Di Ouyang, Pamela Subramanya, Vinita Vaidya, Dhananjay Ndumele, Chiadi E. Guallar, Eliseo Sharma, Kavita Shah, Sanjiv J. Kass, David A. Hoogeveen, Ron C. Lima, Joao A. Heckbert, Susan R. deFilippi, Christopher R. Post, Wendy S. Michos, Erin D. J Am Heart Assoc Original Research BACKGROUND: cGMP mediates numerous cardioprotective functions and is a potential therapeutic target for cardiovascular disease. Preclinical studies suggest that plasma cGMP is reflective of natriuretic peptide stimulation. Epidemiologic associations between cGMP and natriuretic peptide, as well as cardiovascular disease risk factors, are unknown. METHODS AND RESULTS: We measured plasma cGMP in 542 men and 496 women free of cardiovascular disease and heart failure in MESA (Multi‐Ethnic Study of Atherosclerosis). Cross‐sectional associations of N‐terminal pro‐B type natriuretic peptide, sex hormones, and cardiovascular disease/heart failure risk factors with log(cGMP) were analyzed using multivariable linear regression models. Mean (SD) cGMP was 4.7 (2.6) pmol/mL, with no difference between the sexes. After adjusting for cardiovascular risk factors, N‐terminal pro‐B type natriuretic peptide was significantly positively associated with cGMP (P<0.05). Higher blood pressure and lower estimated glomerular filtration rate were associated with higher cGMP (P<0.05). Triglyceride levels, total/high‐density lipoprotein cholesterol ratio, presence of diabetes mellitus, and the homeostatic model assessment of insulin resistance were inversely associated with cGMP (P<0.05). Among women, free testosterone and dehydroepiandrosterone were inversely associated with cGMP, while sex hormone binding globulin was positively associated (P<0.05). CONCLUSIONS: In a community‐cohort, plasma cGMP was associated with natriuretic peptide signaling. Higher blood pressure and greater renal dysfunction were positively associated with cGMP, while adverse metabolic risk factors were inversely associated. Increased androgenicity in postmenopausal women was inversely associated with cGMP. These novel associations further our understanding of the role of cGMP in a general population. John Wiley and Sons Inc. 2019-12-16 /pmc/articles/PMC6951064/ /pubmed/31838972 http://dx.doi.org/10.1161/JAHA.119.013149 Text en © 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Research
Ying, Wendy
Zhao, Di
Ouyang, Pamela
Subramanya, Vinita
Vaidya, Dhananjay
Ndumele, Chiadi E.
Guallar, Eliseo
Sharma, Kavita
Shah, Sanjiv J.
Kass, David A.
Hoogeveen, Ron C.
Lima, Joao A.
Heckbert, Susan R.
deFilippi, Christopher R.
Post, Wendy S.
Michos, Erin D.
Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA
title Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA
title_full Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA
title_fullStr Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA
title_full_unstemmed Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA
title_short Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA
title_sort associations between the cyclic guanosine monophosphate pathway and cardiovascular risk factors: mesa
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951064/
https://www.ncbi.nlm.nih.gov/pubmed/31838972
http://dx.doi.org/10.1161/JAHA.119.013149
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