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Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA
BACKGROUND: cGMP mediates numerous cardioprotective functions and is a potential therapeutic target for cardiovascular disease. Preclinical studies suggest that plasma cGMP is reflective of natriuretic peptide stimulation. Epidemiologic associations between cGMP and natriuretic peptide, as well as c...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951064/ https://www.ncbi.nlm.nih.gov/pubmed/31838972 http://dx.doi.org/10.1161/JAHA.119.013149 |
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author | Ying, Wendy Zhao, Di Ouyang, Pamela Subramanya, Vinita Vaidya, Dhananjay Ndumele, Chiadi E. Guallar, Eliseo Sharma, Kavita Shah, Sanjiv J. Kass, David A. Hoogeveen, Ron C. Lima, Joao A. Heckbert, Susan R. deFilippi, Christopher R. Post, Wendy S. Michos, Erin D. |
author_facet | Ying, Wendy Zhao, Di Ouyang, Pamela Subramanya, Vinita Vaidya, Dhananjay Ndumele, Chiadi E. Guallar, Eliseo Sharma, Kavita Shah, Sanjiv J. Kass, David A. Hoogeveen, Ron C. Lima, Joao A. Heckbert, Susan R. deFilippi, Christopher R. Post, Wendy S. Michos, Erin D. |
author_sort | Ying, Wendy |
collection | PubMed |
description | BACKGROUND: cGMP mediates numerous cardioprotective functions and is a potential therapeutic target for cardiovascular disease. Preclinical studies suggest that plasma cGMP is reflective of natriuretic peptide stimulation. Epidemiologic associations between cGMP and natriuretic peptide, as well as cardiovascular disease risk factors, are unknown. METHODS AND RESULTS: We measured plasma cGMP in 542 men and 496 women free of cardiovascular disease and heart failure in MESA (Multi‐Ethnic Study of Atherosclerosis). Cross‐sectional associations of N‐terminal pro‐B type natriuretic peptide, sex hormones, and cardiovascular disease/heart failure risk factors with log(cGMP) were analyzed using multivariable linear regression models. Mean (SD) cGMP was 4.7 (2.6) pmol/mL, with no difference between the sexes. After adjusting for cardiovascular risk factors, N‐terminal pro‐B type natriuretic peptide was significantly positively associated with cGMP (P<0.05). Higher blood pressure and lower estimated glomerular filtration rate were associated with higher cGMP (P<0.05). Triglyceride levels, total/high‐density lipoprotein cholesterol ratio, presence of diabetes mellitus, and the homeostatic model assessment of insulin resistance were inversely associated with cGMP (P<0.05). Among women, free testosterone and dehydroepiandrosterone were inversely associated with cGMP, while sex hormone binding globulin was positively associated (P<0.05). CONCLUSIONS: In a community‐cohort, plasma cGMP was associated with natriuretic peptide signaling. Higher blood pressure and greater renal dysfunction were positively associated with cGMP, while adverse metabolic risk factors were inversely associated. Increased androgenicity in postmenopausal women was inversely associated with cGMP. These novel associations further our understanding of the role of cGMP in a general population. |
format | Online Article Text |
id | pubmed-6951064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-69510642020-01-10 Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA Ying, Wendy Zhao, Di Ouyang, Pamela Subramanya, Vinita Vaidya, Dhananjay Ndumele, Chiadi E. Guallar, Eliseo Sharma, Kavita Shah, Sanjiv J. Kass, David A. Hoogeveen, Ron C. Lima, Joao A. Heckbert, Susan R. deFilippi, Christopher R. Post, Wendy S. Michos, Erin D. J Am Heart Assoc Original Research BACKGROUND: cGMP mediates numerous cardioprotective functions and is a potential therapeutic target for cardiovascular disease. Preclinical studies suggest that plasma cGMP is reflective of natriuretic peptide stimulation. Epidemiologic associations between cGMP and natriuretic peptide, as well as cardiovascular disease risk factors, are unknown. METHODS AND RESULTS: We measured plasma cGMP in 542 men and 496 women free of cardiovascular disease and heart failure in MESA (Multi‐Ethnic Study of Atherosclerosis). Cross‐sectional associations of N‐terminal pro‐B type natriuretic peptide, sex hormones, and cardiovascular disease/heart failure risk factors with log(cGMP) were analyzed using multivariable linear regression models. Mean (SD) cGMP was 4.7 (2.6) pmol/mL, with no difference between the sexes. After adjusting for cardiovascular risk factors, N‐terminal pro‐B type natriuretic peptide was significantly positively associated with cGMP (P<0.05). Higher blood pressure and lower estimated glomerular filtration rate were associated with higher cGMP (P<0.05). Triglyceride levels, total/high‐density lipoprotein cholesterol ratio, presence of diabetes mellitus, and the homeostatic model assessment of insulin resistance were inversely associated with cGMP (P<0.05). Among women, free testosterone and dehydroepiandrosterone were inversely associated with cGMP, while sex hormone binding globulin was positively associated (P<0.05). CONCLUSIONS: In a community‐cohort, plasma cGMP was associated with natriuretic peptide signaling. Higher blood pressure and greater renal dysfunction were positively associated with cGMP, while adverse metabolic risk factors were inversely associated. Increased androgenicity in postmenopausal women was inversely associated with cGMP. These novel associations further our understanding of the role of cGMP in a general population. John Wiley and Sons Inc. 2019-12-16 /pmc/articles/PMC6951064/ /pubmed/31838972 http://dx.doi.org/10.1161/JAHA.119.013149 Text en © 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Research Ying, Wendy Zhao, Di Ouyang, Pamela Subramanya, Vinita Vaidya, Dhananjay Ndumele, Chiadi E. Guallar, Eliseo Sharma, Kavita Shah, Sanjiv J. Kass, David A. Hoogeveen, Ron C. Lima, Joao A. Heckbert, Susan R. deFilippi, Christopher R. Post, Wendy S. Michos, Erin D. Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA |
title | Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA |
title_full | Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA |
title_fullStr | Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA |
title_full_unstemmed | Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA |
title_short | Associations Between the Cyclic Guanosine Monophosphate Pathway and Cardiovascular Risk Factors: MESA |
title_sort | associations between the cyclic guanosine monophosphate pathway and cardiovascular risk factors: mesa |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951064/ https://www.ncbi.nlm.nih.gov/pubmed/31838972 http://dx.doi.org/10.1161/JAHA.119.013149 |
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