Cargando…

Pharmacological Inhibition of Serine Proteases to Reduce Cardiac Inflammation and Fibrosis in Atrial Fibrillation

Systemic inflammation correlates with an increased risk of atrial fibrillation (AF) and thrombogenesis. Systemic inflammation alters vessel permeability, allowing inflammatory and immune cell migration toward target organs, including the heart. Among inflammatory cells infiltrating the atria, macrop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Coppini, Raffaele, Santini, Lorenzo, Palandri, Chiara, Sartiani, Laura, Cerbai, Elisabetta, Raimondi, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6951407/ https://www.ncbi.nlm.nih.gov/pubmed/31956307 http://dx.doi.org/10.3389/fphar.2019.01420

Ejemplares similares

Selective Blockade of HCN1/HCN2 Channels as a Potential Pharmacological Strategy Against Pain
por: Dini, Leonardo, et al.
Publicado: (2018)

Cardiac safety assessment of a novel recombinant bispecific antibody targeting the ether-à-go-go related gene 1 (hERG1)-β1 integrin macromolecular complex
por: Santini, Lorenzo, et al.
Publicado: (2023)

Ion Channel Impairment and Myofilament Ca(2+) Sensitization: Two Parallel Mechanisms Underlying Arrhythmogenesis in Hypertrophic Cardiomyopathy
por: Santini, Lorenzo, et al.
Publicado: (2021)

Regulation of intracellular Na(+) in health and disease: pathophysiological mechanisms and implications for treatment
por: Coppini, Raffaele, et al.
Publicado: (2013)

Pharmacological basis of the antifibrotic effects of pirfenidone: Mechanistic insights from cardiac in-vitro and in-vivo models
por: Sartiani, Laura, et al.
Publicado: (2022)

Pharmacological Management of Hypertrophic Cardiomyopathy: From Bench to Bedside
por: Palandri, Chiara, et al.
Publicado: (2022)

Genotype-Driven Pathogenesis of Atrial Fibrillation in Hypertrophic Cardiomyopathy: The Case of Different TNNT2 Mutations
por: Pioner, Josè Manuel, et al.
Publicado: (2022)

Optical Investigation of Action Potential and Calcium Handling Maturation of hiPSC-Cardiomyocytes on Biomimetic Substrates
por: Pioner, Josè Manuel, et al.
Publicado: (2019)

Isoproterenol Increases Left Atrial Fibrosis and Susceptibility to Atrial Fibrillation by Inducing Atrial Ischemic Infarction in Rats
por: Ma, Shiyu, et al.
Publicado: (2020)

Discovery of Leishmania Druggable Serine Proteases by Activity-Based Protein Profiling
por: Porta, Exequiel O. J., et al.
Publicado: (2022)

Angiotensin-II Drives Human Satellite Cells Toward Hypertrophy and Myofibroblast Trans-Differentiation by Two Independent Pathways
por: Laurino, Annunziatina, et al.
Publicado: (2019)

R4496C RyR2 mutation impairs atrial and ventricular contractility
por: Ferrantini, Cecilia, et al.
Publicado: (2016)

The Effect of a Novel Serine Protease Inhibitor on Inflammation and Intestinal Permeability in a Murine Colitis Transfer Model
por: Van Spaendonk, Hanne, et al.
Publicado: (2021)

Potential Simultaneous Inhibitors of Angiotensin-Converting Enzyme 2 and Transmembrane Protease, Serine 2
por: Wu, Ching-Yuan, et al.
Publicado: (2020)

The Effect of Serine Protease Inhibitors on Visceral Pain in Different Rodent Models With an Intestinal Insult
por: Ceuleers, Hannah, et al.
Publicado: (2022)

Altered Ca(2+) and Na(+) Homeostasis in Human Hypertrophic Cardiomyopathy: Implications for Arrhythmogenesis
por: Coppini, Raffaele, et al.
Publicado: (2018)

The Antimalarial Chloroquine Reduces the Burden of Persistent Atrial Fibrillation
por: Tobón, Catalina, et al.
Publicado: (2019)

Hydrogen Sulfide Ameliorates Angiotensin II-Induced Atrial Fibrosis Progression to Atrial Fibrillation Through Inhibition of the Warburg Effect and Endoplasmic Reticulum Stress
por: Hu, Heng-Jing, et al.
Publicado: (2021)

The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung
por: Twigg, Matthew S., et al.
Publicado: (2015)

LncRNA Nuclear-Enriched Abundant Transcript 1 Regulates Atrial Fibrosis via the miR-320/NPAS2 Axis in Atrial Fibrillation
por: Dai, Huangdong, et al.
Publicado: (2021)

An instrument to measure atrial fibrillation knowledge in Chinese patients: validation of the Jessa Atrial fibrillation Knowledge Questionnaire
por: Chang, Sijie, et al.
Publicado: (2023)

Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes
por: Paci, Michelangelo, et al.
Publicado: (2012)

HCN Channels Modulators: The Need for Selectivity
por: Romanelli, Maria Novella, et al.
Publicado: (2016)

A Putative Serine Protease is Required to Initiate the RIPK3-MLKL—Mediated Necroptotic Death Pathway in Neutrophils
por: Wang, Xiaoliang, et al.
Publicado: (2021)

Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy: A Translational Study
por: Coppini, Raffaele, et al.
Publicado: (2019)

Cysteine Proteases: Modes of Activation and Future Prospects as Pharmacological Targets
por: Verma, Sonia, et al.
Publicado: (2016)

The effect of pharmacological inhibition of Serine Proteases on neuronal networks in vitro
por: Van De Vijver, Sebastiaan, et al.
Publicado: (2019)

Metabolomic Analysis by Nuclear Magnetic Resonance Spectroscopy as a New Approach to Understanding Inflammation and Monitoring of Pharmacological Therapy in Children and Young Adults With Cystic Fibrosis
por: Montuschi, Paolo, et al.
Publicado: (2018)

Serratiopeptidase, A Serine Protease Anti-Inflammatory, Fibrinolytic, and Mucolytic Drug, Can Be a Useful Adjuvant for Management in COVID-19
por: Sharma, Charu, et al.
Publicado: (2021)

Honokiol Inhibits Atrial Metabolic Remodeling in Atrial Fibrillation Through Sirt3 Pathway
por: Liu, Guang Zhong, et al.
Publicado: (2022)

Pharmacological and Non-pharmacological Treatments for Stroke Prevention in Patients with Atrial Fibrillation
por: Ueberham, Laura, et al.
Publicado: (2017)

Late sodium current inhibitors to treat exercise‐induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium
por: Ferrantini, Cecilia, et al.
Publicado: (2018)

Calcium dysregulation in atrial fibrillation: the role of CaMKII
por: Heijman, Jordi, et al.
Publicado: (2014)

Pharmacological approaches to pulmonary fibrosis following COVID-19
por: Lassan, Stefan, et al.
Publicado: (2023)

Non-Pharmacological Stroke Prevention in Atrial Fibrillation
por: Anduaga, Iñigo, et al.
Publicado: (2023)

Sacubitril/Valsartan Improves Left Atrial and Left Atrial Appendage Function in Patients With Atrial Fibrillation and in Pressure Overload-Induced Mice
por: Suo, Ya, et al.
Publicado: (2019)

Initiation and Persistence with Warfarin Therapy in Atrial Fibrillation According to Ethnicity
por: Hansen, Carolina Malta, et al.
Publicado: (2012)

Anticancer Therapy-Induced Atrial Fibrillation: Electrophysiology and Related Mechanisms
por: Yang, Xinyu, et al.
Publicado: (2018)

Factors Associated With Edoxaban Concentration Among Patients With Atrial Fibrillation
por: Lin, Shin-Yi, et al.
Publicado: (2021)

Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy
por: Passini, Elisa, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_cb71nf9f423o236c19kugauc4o